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Journal articles
The extravascular compartment of the bone marrow: a niche for Plasmodium falciparum gametocyte maturation?
Abstract : ABSTRACT: BACKGROUND: Plasmodium falciparum immature gametocytes accumulate in the bone marrow, but their exact location in this tissue remains unclear. METHODS: The stage and deposition pattern of gametocytes was analysed on histological sections of a bone marrow sample collected in a patient with subacute P. falciparum malaria. RESULTS: A majority (89%) of immature stages II to IV gametocytes and a minority (29%) of mature stage V gametocytes were observed in extravascular spaces. Discussion and conclusion These observations represent a valuable step towards understanding sequestration patterns of P. falciparum gametocytes and may ultimately lead to novel transmission-blocking interventions.
Cited literature [11 references]
https://www.hal.inserm.fr/inserm-00741807
Contributor : Ed. Bmc <>
Submitted on : Monday, October 15, 2012 - 1:07:33 PM
Last modification on : Friday, May 28, 2021 - 4:40:02 PM
Long-term archiving on: : Wednesday, January 16, 2013 - 3:38:14 AM
Contributor : Ed. Bmc <>
Submitted on : Monday, October 15, 2012 - 1:07:33 PM
Last modification on : Friday, May 28, 2021 - 4:40:02 PM
Long-term archiving on: : Wednesday, January 16, 2013 - 3:38:14 AM