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The extravascular compartment of the bone marrow: a niche for Plasmodium falciparum gametocyte maturation?

Abstract : ABSTRACT: BACKGROUND: Plasmodium falciparum immature gametocytes accumulate in the bone marrow, but their exact location in this tissue remains unclear. METHODS: The stage and deposition pattern of gametocytes was analysed on histological sections of a bone marrow sample collected in a patient with subacute P. falciparum malaria. RESULTS: A majority (89%) of immature stages II to IV gametocytes and a minority (29%) of mature stage V gametocytes were observed in extravascular spaces. Discussion and conclusion These observations represent a valuable step towards understanding sequestration patterns of P. falciparum gametocytes and may ultimately lead to novel transmission-blocking interventions.
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Submitted on : Monday, October 15, 2012 - 1:07:33 PM
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Eric Farfour, Frédéric Charlotte, Catherine Settegrana, Makoto Miyara, Pierre Buffet. The extravascular compartment of the bone marrow: a niche for Plasmodium falciparum gametocyte maturation?. Malaria Journal, BioMed Central, 2012, 11 (1), pp.285. ⟨10.1186/1475-2875-11-285⟩. ⟨inserm-00741807⟩

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