The extravascular compartment of the bone marrow: a niche for Plasmodium falciparum gametocyte maturation? - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Malaria Journal Year : 2012

The extravascular compartment of the bone marrow: a niche for Plasmodium falciparum gametocyte maturation?

Abstract

ABSTRACT: BACKGROUND: Plasmodium falciparum immature gametocytes accumulate in the bone marrow, but their exact location in this tissue remains unclear. METHODS: The stage and deposition pattern of gametocytes was analysed on histological sections of a bone marrow sample collected in a patient with subacute P. falciparum malaria. RESULTS: A majority (89%) of immature stages II to IV gametocytes and a minority (29%) of mature stage V gametocytes were observed in extravascular spaces. Discussion and conclusion These observations represent a valuable step towards understanding sequestration patterns of P. falciparum gametocytes and may ultimately lead to novel transmission-blocking interventions.
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Dates and versions

inserm-00741807 , version 1 (15-10-2012)

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Eric Farfour, Frédéric Charlotte, Catherine Settegrana, Makoto Miyara, Pierre Buffet. The extravascular compartment of the bone marrow: a niche for Plasmodium falciparum gametocyte maturation?. Malaria Journal, 2012, 11 (1), pp.285. ⟨10.1186/1475-2875-11-285⟩. ⟨inserm-00741807⟩
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