D. Albert, I. Zundorf, T. Dingermann, and W. Muller, Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase, Biochemical Pharmacology, vol.64, issue.12, pp.1767-1775, 2002.
DOI : 10.1016/S0006-2952(02)01387-4

L. Beerhues, Hyperforin, Phytochemistry, vol.67, issue.20, pp.2201-2207, 2006.
DOI : 10.1016/j.phytochem.2006.08.017

J. Bessa, D. Ferreira, I. Melo, and F. Marques, The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling, Molecular Psychiatry, vol.17, issue.8, pp.764-773, 2009.
DOI : 10.1038/sj.npp.1301183

A. Bouron, X. Altafaj, S. Boisseau, D. Waard, and M. , A store-operated Ca2+ influx activated in response to the depletion of thapsigargin-sensitive Ca2+ stores is developmentally regulated in embryonic cortical neurons from mice, Developmental Brain Research, vol.159, issue.1, pp.64-71, 2005.
DOI : 10.1016/j.devbrainres.2005.07.001

URL : https://hal.archives-ouvertes.fr/inserm-00381727

L. Cervo, M. Rozio, C. Ekalle-soppo, and G. Guiso, Role of hyperforin in the antidepressant-like activity of Hypericum perforatum extracts, Psychopharmacology, vol.164, issue.4, pp.423-428, 2002.
DOI : 10.1007/s00213-002-1229-5

S. Chatterjee, V. Filippov, P. Lishko, and O. Maximyuk, Hyperforin attenuates various ionic conductance mechanisms in the isolated hippocampal neurons of rat, Life Sciences, vol.65, issue.22, pp.2395-2405, 1999.
DOI : 10.1016/S0024-3205(99)00506-8

S. Chatterjee, S. Bhattacharya, M. Wonnemann, and A. Singer, Hyperforin as a possible antidepressant component of hypericum extracts, Life Sciences, vol.63, issue.6, pp.499-510, 1998.
DOI : 10.1016/S0024-3205(98)00299-9

S. Chatterjee, M. Noldner, E. Koch, and C. Erdelmeier, Antidepressant Activity of Hypericum Perforatum and Hyperforin: the Neglected Possibility, Pharmacopsychiatry, vol.31, issue.S 1, pp.7-15, 1998.
DOI : 10.1055/s-2007-979340

Y. Chen and J. Goldstein, The Transcriptional Regulation of the Human CYP2C Genes, Current Drug Metabolism, vol.10, issue.6, pp.567-578, 2009.
DOI : 10.2174/138920009789375397

D. David, B. Samuels, R. Q. Wang, and J. , Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of Anxiety/Depression, Neuron, vol.62, issue.4, pp.479-493, 2009.
DOI : 10.1016/j.neuron.2009.04.017

N. Decarolis and A. Eisch, Hippocampal neurogenesis as a target for the treatment of mental illness: A??critical evaluation, Neuropharmacology, vol.58, issue.6, pp.884-893, 2010.
DOI : 10.1016/j.neuropharm.2009.12.013

D. Carlo, G. Borrelli, F. Ernst, E. Izzo, and A. , St John's wort: Prozac from the plant kingdom, Trends in Pharmacological Sciences, vol.22, issue.6, pp.292-297, 2001.
DOI : 10.1016/S0165-6147(00)01716-8

R. Duman and L. Monteggia, A Neurotrophic Model for Stress-Related Mood Disorders, Biological Psychiatry, vol.59, issue.12, pp.1116-1127, 2006.
DOI : 10.1016/j.biopsych.2006.02.013

D. Dupret, A. Fabre, M. Dobrossy, and A. Panatier, Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons, PLoS Biology, vol.12, issue.8, p.214, 2007.
DOI : 10.1371/journal.pbio.0050214.st005

URL : https://hal.archives-ouvertes.fr/inserm-00708252

D. Dupret, J. Revest, M. Koehl, and F. Ichas, Spatial Relational Memory Requires Hippocampal Adult Neurogenesis, PLoS ONE, vol.24, issue.4, 1959.
DOI : 10.1371/journal.pone.0001959.s009

A. Fisunov, N. Lozovaya, T. Tsintsadze, and S. Chatterjee, Hyperforin modulates gating of P-type Ca2+ current in cerebellar Purkinje neurons, Pfl??gers Archiv - European Journal of Physiology, vol.440, issue.3, pp.427-434, 2000.
DOI : 10.1007/s004240000306

C. Gey, S. Kyrylenko, L. Hennig, and L. Nguyen, Phloroglucinol Derivatives Guttiferone???G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2, Angewandte Chemie International Edition, vol.227, issue.27, pp.5219-5222, 2007.
DOI : 10.1002/anie.200605207

J. Gibon, P. Richaud, and A. Bouron, Hyperforin changes the zinc-storage capacities of brain cells, Neuropharmacology, vol.61, issue.8, pp.1321-1326, 2011.
DOI : 10.1016/j.neuropharm.2011.08.002

URL : https://hal.archives-ouvertes.fr/hal-01060694

K. Holick, D. Lee, R. Hen, and S. Dulawa, Behavioral Effects of Chronic Fluoxetine in BALB/cJ Mice Do Not Require Adult Hippocampal Neurogenesis or the Serotonin 1A Receptor, Neuropsychopharmacology, vol.38, issue.2, pp.406-417, 2008.
DOI : 10.1007/BF01047461

M. Kozisek, D. Middlemas, and D. Bylund, Brain-derived neurotrophic factor and its receptor tropomyosin-related kinase B in the mechanism of action of antidepressant therapies, Pharmacology & Therapeutics, vol.117, issue.1, pp.30-51, 2008.
DOI : 10.1016/j.pharmthera.2007.07.001

V. Kumar, A. Mdzinarishvili, C. Kiewert, and T. Abbruscato, NMDA Receptor-Antagonistic Properties of Hyperforin, a Constituent of St. John???s Wort, Journal of Pharmacological Sciences, vol.102, issue.1, pp.47-54, 2006.
DOI : 10.1254/jphs.FP0060378

G. Legge, M. Martinez-yamout, D. Hambly, and T. Trinh, ZZ Domain of CBP: an Unusual Zinc Finger Fold in a Protein Interaction Module, Journal of Molecular Biology, vol.343, issue.4, pp.1081-1093, 2004.
DOI : 10.1016/j.jmb.2004.08.087

K. Leuner, J. Heiser, S. Derksen, and M. Mladenov, Simple 2,4-Diacylphloroglucinols as Classic Transient Receptor Potential-6 Activators--Identification of a Novel Pharmacophore, Molecular Pharmacology, vol.77, issue.3, pp.368-377, 2010.
DOI : 10.1124/mol.109.057513

?. Hyperforin, . Key, and . St, John's wort specifically activates TRPC6 channels, FASEB Journal, vol.21, pp.4101-4111

Y. Li, B. Luikart, S. Birnbaum, and J. Chen, TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment, Neuron, vol.59, issue.3, pp.399-412, 2008.
DOI : 10.1016/j.neuron.2008.06.023

URL : http://doi.org/10.1016/j.neuron.2008.10.021

B. Lonze and D. Ginty, Function and Regulation of CREB Family Transcription Factors in the Nervous System, Neuron, vol.35, issue.4, pp.605-623, 2002.
DOI : 10.1016/S0896-6273(02)00828-0

G. Lorusso, N. Vannini, I. Sogno, and L. Generoso, Mechanisms of Hyperforin as an anti-angiogenic angioprevention agent, European Journal of Cancer, vol.45, issue.8, pp.1474-1484, 2009.
DOI : 10.1016/j.ejca.2009.01.014

M. Medina, B. Martinez-poveda, M. Amores-sanchez, and A. Quesada, Hyperforin: More than an antidepressant bioactive compound?, Life Sciences, vol.79, issue.2, pp.105-111, 2006.
DOI : 10.1016/j.lfs.2005.12.027

T. Mennini and M. Gobbi, The antidepressant mechanism of Hypericum perforatum, Life Sciences, vol.75, issue.9, pp.1021-1027, 2004.
DOI : 10.1016/j.lfs.2004.04.005

J. Miguel-hidalgo and G. Rajkowska, Morphological Brain Changes in Depression, CNS Drugs, vol.241, issue.5549, pp.361-372, 2002.
DOI : 10.2165/00023210-200216060-00001

. St, John's wort induces hepatic drug metabolism through activation of the pregnane X receptor, Proceedings of National Academy of Sciences USA 97, pp.7500-7502

M. Muller, K. Essin, K. Hill, and H. Beschmann, Specific TRPC6 Channel Activation, a Novel Approach to Stimulate Keratinocyte Differentiation, Journal of Biological Chemistry, vol.283, issue.49, pp.33942-33954, 2008.
DOI : 10.1074/jbc.M801844200

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662218

W. Muller, Current St. John's wort research from mode of action to clinical efficacy, Pharmacological Research, vol.47, issue.2, pp.101-109, 2003.
DOI : 10.1016/S1043-6618(02)00266-9

A. Murray, Pharmacological PKA Inhibition: All May Not Be What It Seems, Science Signaling, vol.1, issue.22, p.4, 2008.
DOI : 10.1126/scisignal.122re4

J. Revest, D. Dupret, M. Koehl, and C. Funk-reiter, Adult hippocampal neurogenesis is involved in anxiety-related behaviors, Molecular Psychiatry, vol.87, issue.10, pp.959-967, 2009.
DOI : 10.1038/nn1919

N. Roz and M. Rehavi, Hyperforin depletes synaptic vesicles content and induces compartmental redistribution of nerve ending monoamines, Life Sciences, vol.75, issue.23, pp.2841-2850, 2004.
DOI : 10.1016/j.lfs.2004.08.004

Z. Saddiqe, I. Naeem, and A. Maimoona, A review of the antibacterial activity of Hypericum perforatum L., Journal of Ethnopharmacology, vol.131, issue.3, pp.511-521, 2010.
DOI : 10.1016/j.jep.2010.07.034

A. Sahay and R. Hen, Adult hippocampal neurogenesis in depression, Nature Neuroscience, vol.104, issue.9, pp.1110-1115, 2007.
DOI : 10.1038/nn1969

A. Sahay, K. Scobie, A. Hill, O. Carroll, and C. , Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation, Nature, vol.98, issue.7344, pp.466-470, 2011.
DOI : 10.1038/nature09817

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084370

L. Santarelli, S. M. Gross, C. Surget, and A. , Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants, Science, vol.301, issue.5634, pp.805-809, 2003.
DOI : 10.1126/science.1083328

R. Sapolsky, Is impaired neurogenesis relevant to the affective symptoms of depression?, Biological Psychiatry, vol.56, issue.3, pp.137-139, 2004.
DOI : 10.1016/j.biopsych.2004.04.012

C. Schempp, K. Pelz, A. Wittmer, and E. Schopf, Antibacterial activity of hyperforin from St John's wort, against multiresistant Staphylococcus aureus and gram-positive bacteria, The Lancet, vol.353, issue.9170, p.2129, 1999.
DOI : 10.1016/S0140-6736(99)00214-7

C. Stevinson and E. Ernst, Hypericum for depression, European Neuropsychopharmacology, vol.9, issue.6, pp.501-505, 1999.
DOI : 10.1016/S0924-977X(99)00032-2

A. Surget, M. Saxe, S. Leman, and Y. Ibarguen-vargas, Drug-Dependent Requirement of Hippocampal Neurogenesis in a Model of Depression and of Antidepressant Reversal, Biological Psychiatry, vol.64, issue.4, pp.293-301, 2008.
DOI : 10.1016/j.biopsych.2008.02.022

A. Surget, A. Tanti, E. Leonardo, and A. Laugeray, Antidepressants recruit new neurons to improve stress response regulation, Molecular Psychiatry, vol.23, issue.12, pp.1177-1188, 2010.
DOI : 10.1038/mp.2011.48

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223314

Y. Tai, S. Feng, R. Ge, and W. Du, TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway, Journal of Cell Science, vol.121, issue.14, pp.2301-2307, 2008.
DOI : 10.1242/jcs.026906

URL : http://jcs.biologists.org/cgi/content/short/121/14/2301

P. Tu, C. Kunert-keil, S. Lucke, and H. Brinkmeier, Diacylglycerol analogues activate second messenger-operated calcium channels exhibiting TRPC-like properties in cortical neurons, Journal of Neurochemistry, vol.130, issue.1, pp.126-138, 2009.
DOI : 10.1111/j.1471-4159.2008.05752.x

URL : https://hal.archives-ouvertes.fr/hal-00403052

R. Wills, K. Bone, and M. Morgan, Herbal products: active constituents, modes of action and quality control, Nutrition Research Reviews, vol.13, issue.01, pp.47-77, 2000.
DOI : 10.1079/095442200108729007

P. Zanoli, Role of Hyperforin in the Pharmacological Activities of St. John's Wort, CNS Drug Reviews, vol.71, issue.Suppl 1, pp.203-218, 2004.
DOI : 10.1111/j.1527-3458.2004.tb00022.x

J. Zhou, W. Du, K. Zhou, and Y. Tai, Critical role of TRPC6 channels in the formation of excitatory synapses, Nature Neuroscience, vol.11, issue.7, pp.741-743, 2008.
DOI : 10.1038/nrn988