P. W. Baas, A. Karabay, and L. Qiang, Microtubules cut and run, Trends in Cell Biology, vol.15, issue.10, pp.518-524, 2005.
DOI : 10.1016/j.tcb.2005.08.004

P. W. Baas and L. Qiang, Neuronal microtubules: when the MAP is the roadblock, Trends in Cell Biology, vol.15, issue.4, pp.183-187, 2005.
DOI : 10.1016/j.tcb.2005.02.001

C. Blackstone, C. J. O-'kane, and E. Reid, Hereditary spastic paraplegias: membrane traffic and the motor pathway, Nat. Rev. Neurosci, vol.12, pp.31-42, 2011.

R. Butler, J. D. Wood, J. A. Landers, and V. T. Cunliffe, Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia, Disease Models & Mechanisms, vol.3, issue.11-12, pp.743-751, 2010.
DOI : 10.1242/dmm.004002

N. R. Cashman, H. D. Durham, J. K. Blusztajn, K. Oda, T. Tabira et al., Neuroblastoma ?? spinal cord (NSC) hybrid cell lines resemble developing motor neurons, Developmental Dynamics, vol.319, issue.3, pp.209-221, 1992.
DOI : 10.1002/aja.1001940306

D. Charvin, C. Cifuentes-diaz, N. Fonknechten, V. Joshi, J. Hazan et al., Mutations of SPG4 are responsible for a loss of function of spastin, an abundant neuronal protein localized in the nucleus, Human Molecular Genetics, vol.12, issue.1, pp.71-78, 2003.
DOI : 10.1093/hmg/ddg004

P. Claudiani, E. Riano, A. Errico, G. Andolfi, and E. I. Rugarli, Spastin subcellular localization is regulated through usage of different translation start sites and active export from the nucleus, Experimental Cell Research, vol.309, issue.2, pp.358-369, 2005.
DOI : 10.1016/j.yexcr.2005.06.009

J. W. Connell, C. Lindon, J. P. Luzio, and E. Reid, Spastin Couples Microtubule Severing to Membrane Traffic in Completion of Cytokinesis and Secretion, Traffic, vol.6, issue.1, pp.42-56, 2009.
DOI : 10.1111/j.1600-0854.2008.00847.x

F. Du, E. F. Ozdowski, I. K. Kotowski, D. A. Marchuk, and N. T. Sherwood, Functional conservation of human Spastin in a Drosophila model of autosomal dominant-hereditary spastic paraplegia, Human Molecular Genetics, vol.19, issue.10, pp.1883-1896, 2010.
DOI : 10.1093/hmg/ddq064

A. Errico, A. Ballabio, and E. I. Rugarli, Spastin, the protein mutated in autosomal dominant hereditary spastic paraplegia, is involved in microtubule dynamics, Human Molecular Genetics, vol.11, issue.2, 2002.
DOI : 10.1093/hmg/11.2.153

A. Errico, P. Claudiani, M. D-'addio, and E. I. Rugarli, Spastin interacts with the centrosomal protein NA14, and is enriched in the spindle pole, the midbody and the distal axon, Human Molecular Genetics, vol.13, issue.18, pp.2121-2132, 2004.
DOI : 10.1093/hmg/ddh223

J. K. Fink, Hereditary spastic paraplegia, Current Neurology and Neuroscience Reports, vol.94, issue.1, pp.65-76, 2006.
DOI : 10.1007/s11910-996-0011-1

URL : http://citeseerx.ist.psu.edu/viewdoc/summary?doi=

N. Fonknechten, D. Mavel, P. Byrne, C. S. Davoine, C. Cruaud et al., Spectrum of SPG4 mutations in autosomal dominant spastic paraplegia, Human Molecular Genetics, vol.9, issue.4, pp.637-644, 2000.
DOI : 10.1093/hmg/9.4.637

T. Frugier, F. D. Tiziano, C. Cifuentes-diaz, P. Miniou, N. Roblot et al., Nuclear targeting defect of SMN lacking the C-terminus in a mouse model of spinal muscular atrophy, Human Molecular Genetics, vol.9, issue.5, pp.849-858, 2000.
DOI : 10.1093/hmg/9.5.849

G. G. Gundersen, M. H. Kalnoski, and J. C. Bulinski, Distinct populations of microtubules: Tyrosinated and nontyrosinated alpha tubulin are distributed differently in vivo, Cell, vol.38, issue.3, pp.779-789, 1984.
DOI : 10.1016/0092-8674(84)90273-3

J. Hazan, N. Fonknechten, D. Mavel, C. Paternotte, D. Samson et al., Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia, Nature Genetics, vol.23, issue.3, pp.296-303, 1999.
DOI : 10.1038/15472

M. A. Jordan and L. Wilson, Kinetic analysis of tubulin exchange at microtubule ends at low vinblastine concentrations, Biochemistry, vol.29, issue.11, pp.2730-2739, 1990.
DOI : 10.1021/bi00463a016

M. A. Jordan, D. Thrower, and L. Wilson, Mechanism of inhibition of cell proliferation by Vinca alkaloids, Cancer Res, vol.51, pp.2212-2222, 1991.

M. A. Jordan, R. J. Toso, D. Thrower, and L. Wilson, Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations., Proc. Natl. Acad. Sci. USA 90, pp.9552-9556, 1993.
DOI : 10.1073/pnas.90.20.9552

M. A. Jordan and L. Wilson, Microtubules as a target for anticancer drugs, Nature Reviews Cancer, vol.4, issue.4, pp.253-265, 2004.
DOI : 10.1038/nrc1317

A. Karabay, W. Yu, J. M. Solowska, D. H. Baird, and P. W. Baas, Axonal Growth Is Sensitive to the Levels of Katanin, a Protein That Severs Microtubules, Journal of Neuroscience, vol.24, issue.25, pp.5778-5788, 2004.
DOI : 10.1523/JNEUROSCI.1382-04.2004

B. Lacroix, J. Van-dijk, N. D. Gold, J. Guizetti, G. Aldrian-herrada et al., Tubulin polyglutamylation stimulates spastin-mediated microtubule severing, The Journal of Cell Biology, vol.59, issue.6, pp.945-954, 2010.
DOI : 10.1083/jcb.200612011

URL : https://hal.archives-ouvertes.fr/hal-00509804

W. I. Lencer, T. R. Hirst, and R. K. Holmes, Membrane traffic and the cellular uptake of cholera toxin, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1450, issue.3, pp.177-190, 1999.
DOI : 10.1016/S0167-4889(99)00070-1

J. Lumb, J. Connell, R. Allison, and R. E. , The AAA ATPase spastin links microtubule severing to membrane modelling, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1823, issue.1, pp.192-197, 2012.
DOI : 10.1016/j.bbamcr.2011.08.010

D. L. Ma, S. C. Chia, Y. C. Tang, M. L. Chang, A. Probst et al., Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy, Neurochemistry International, vol.49, issue.7, pp.651-664, 2006.
DOI : 10.1016/j.neuint.2006.05.008

S. H. Park, P. P. Zhu, R. L. Parker, and C. Blackstone, Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network, Journal of Clinical Investigation, vol.120, issue.4, pp.1097-1110, 2010.
DOI : 10.1172/JCI40979DS1

L. Peris, M. Wagenbach, L. Lafanechère, J. Brocard, A. T. Moore et al., Motor-dependent microtubule disassembly driven by tubulin tyrosination, The Journal of Cell Biology, vol.108, issue.7, pp.1159-1166, 2009.
DOI : 10.1083/jcb.105.1.265

URL : https://hal.archives-ouvertes.fr/inserm-00410220

P. Pierre, J. Scheel, J. E. Rickard, and T. E. Kreis, CLIP-170 links endocytic vesicles to microtubules, Cell, vol.70, issue.6, pp.887-900, 1992.
DOI : 10.1016/0092-8674(92)90240-D

L. Qiang, W. Yu, M. Liu, J. M. Solowska, and P. W. Baas, Basic Fibroblast Growth Factor Elicits Formation of Interstitial Axonal Branches via Enhanced Severing of Microtubules, Molecular Biology of the Cell, vol.21, issue.2, 2010.
DOI : 10.1091/mbc.E09-09-0834

E. Reid, Science in motion: common molecular pathological themes emerge in the hereditary spastic paraplegias, Journal of Medical Genetics, vol.40, issue.2, pp.81-86, 2003.
DOI : 10.1136/jmg.40.2.81

E. Riano, M. Martignoni, G. Mancuso, D. Cartelli, F. Crippa et al., Pleiotropic effects of spastin on neurite growth depending on expression levels, Journal of Neurochemistry, vol.177, issue.5, pp.1277-1288, 2009.
DOI : 10.1111/j.1471-4159.2009.05875.x

J. E. Rickard and T. E. Kreis, CLIPs for organellemicrotubule interactions, Trends in Cell Biology, vol.6, issue.5, pp.178-183, 1996.
DOI : 10.1016/0962-8924(96)10017-9

A. Roll-mecak and R. D. Vale, The Drosophila Homologue of the Hereditary Spastic Paraplegia Protein, Spastin, Severs and Disassembles Microtubules, Current Biology, vol.15, issue.7, pp.650-655, 2005.
DOI : 10.1016/j.cub.2005.02.029

A. Roll-mecak and R. D. Vale, Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin, Nature, vol.303, issue.7176, pp.363-367, 2008.
DOI : 10.1038/nature06482

L. C. Ronn, I. Ralets, B. P. Hartz, M. Bech, A. Berezin et al., A simple procedure for quantification of neurite outgrowth based on stereological principles, Journal of Neuroscience Methods, vol.100, issue.1-2, pp.25-32, 2000.
DOI : 10.1016/S0165-0270(00)00228-4

S. Salinas, R. E. Carazo-salas, C. Proukakis, J. M. Cooper, A. E. Weston et al., Human spastin has multiple microtubule-related functions, Journal of Neurochemistry, vol.143, issue.5, pp.1411-1420, 2005.
DOI : 10.1111/j.1471-4159.2005.03472.x

S. Salinas, C. Proukakis, A. Crosby, and T. T. Warner, Hereditary spastic paraplegia: clinical features and pathogenetic mechanisms, The Lancet Neurology, vol.7, issue.12, pp.1127-1138, 2008.
DOI : 10.1016/S1474-4422(08)70258-8

N. T. Sherwood, Q. Sun, M. Xue, B. Zhang, and K. Zinn, Drosophila Spastin Regulates Synaptic Microtubule Networks and Is Required for Normal Motor Function, PLoS Biology, vol.22, issue.12, 2004.
DOI : 10.1371/journal.pbio.0020429.sv001

URL : http://doi.org/10.1371/journal.pbio.0020429

J. M. Solowska, G. Morfini, A. Falnikar, B. T. Himes, S. T. Brady et al., Quantitative and Functional Analyses of Spastin in the Nervous System: Implications for Hereditary Spastic Paraplegia, Journal of Neuroscience, vol.28, issue.9, pp.2147-2157, 2008.
DOI : 10.1523/JNEUROSCI.3159-07.2008

J. M. Solowska, J. Y. Garbern, and P. W. Baas, Evaluation of loss of function as an explanation for SPG4-based hereditary spastic paraplegia, Human Molecular Genetics, vol.19, issue.14, pp.2767-2779, 2010.
DOI : 10.1093/hmg/ddq177

T. Stepanova, J. Slemmer, C. Hoogenraad, G. Lansbergen, B. Dortland et al., Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3- green fluorescent protein), J Neurosci, vol.23, pp.2655-2664, 2003.

D. M. Suter, A. W. Schaefer, and P. Forscher, Microtubule Dynamics Are Necessary for Src Family Kinase-Dependent Growth Cone Steering, Current Biology, vol.14, issue.13, pp.1194-1199, 2004.
DOI : 10.1016/j.cub.2004.06.049

E. Tanaka, T. Ho, and M. W. Kirschner, The role of microtubule dynamics in growth cone motility and axonal growth, The Journal of Cell Biology, vol.128, issue.1, pp.139-155, 1995.
DOI : 10.1083/jcb.128.1.139

A. Tarrade, C. Fassier, S. Courageot, D. Charvin, J. Vitte et al., A mutation of spastin is responsible for swellings and impairment of transport Disease Models & Mechanisms DMM Accepted manuscript, 2006.