E. Al-saleh, M. Nandakumaran, M. Shammari, F. Al-falah, and A. Harouny, Assessment of maternal???fetal status of some essential trace elements in pregnant women in late gestation: relationship with birth weight and placental weight, The Journal of Maternal-Fetal & Neonatal Medicine, vol.42, issue.1, pp.9-14, 2004.
DOI : 10.1080/14767050412331283157

R. F. Beers, . Jr, and I. W. Sizer, A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase, J Biol Chem, vol.195, pp.133-140, 1952.

P. Borella, A. Szilagyi, G. Than, I. Csaba, A. Giardino et al., Maternal plasma concentrations of magnesium, calcium, zinc and copper in normal and pathological pregnancies, Science of The Total Environment, vol.99, issue.1-2, pp.67-76, 1990.
DOI : 10.1016/0048-9697(90)90212-D

S. Borrello, D. Leo, M. Landriscina, M. Palazzotti, B. Galeotti et al., Diethyldithiocarbamate Treatment Up Regulates Manganese Superoxide Dismutase Gene Expression in Rat Liver, Biochemical and Biophysical Research Communications, vol.220, issue.3, pp.546-552, 1996.
DOI : 10.1006/bbrc.1996.0441

S. Brouillet, P. Hoffmann, M. Benharouga, A. Salomon, J. Schaal et al., Molecular Characterization of EG-VEGF-mediated Angiogenesis: Differential Effects on Microvascular and Macrovascular Endothelial Cells, Molecular Biology of the Cell, vol.21, issue.16, pp.2832-2875
DOI : 10.1091/mbc.E10-01-0059
URL : https://hal.archives-ouvertes.fr/hal-01142931

D. Brown, K. Qin, J. Herms, A. Madlung, J. Manson et al., The cellular prion protein binds copper in vivo, Nature, vol.390, pp.684-691, 1997.

H. Bueler, A. Aguzzi, A. Sailer, R. Greiner, P. Autenried et al., Mice devoid of PrP are resistant to scrapie, Cell, vol.73, issue.7, pp.1339-1386, 1993.
DOI : 10.1016/0092-8674(93)90360-3

H. Bueler, M. Fischer, Y. Lang, H. Bluethmann, H. Lipp et al., Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein, Nature, vol.356, issue.6370, pp.577-82, 1992.
DOI : 10.1038/356577a0

G. Burton and . Oxygen, Oxygen, the Janus gas; its effects on human placental development and function, Journal of Anatomy, vol.23, issue.Suppl A, pp.27-35, 2009.
DOI : 10.1111/j.1469-7580.2008.00978.x

A. Buschmann, T. Kuczius, W. Bodemer, and M. Groschup, Cellular Prion Proteins of Mammalian Species Display an Intrinsic Partial Proteinase K Resistance, Biochemical and Biophysical Research Communications, vol.253, issue.3, pp.693-702, 1998.
DOI : 10.1006/bbrc.1998.9838

R. Byrnes, M. Mohan, W. Antholine, R. Xu, and D. Petering, Oxidative stress induced by a copper-thiosemicarbazone complex, Biochemistry, vol.29, issue.30, pp.7046-7053, 1990.
DOI : 10.1021/bi00482a014

K. Camphausen, M. Sproull, S. Tantama, V. Venditto, S. Sankineni et al., Evaluation of chelating agents as anti-angiogenic therapy through copper chelation, Bioorganic & Medicinal Chemistry, vol.12, issue.19, pp.5133-5173, 2004.
DOI : 10.1016/j.bmc.2004.07.034

P. Carmeliet and R. Jain, Molecular mechanisms and clinical applications of angiogenesis, Nature, vol.464, issue.7347, pp.298-307
DOI : 10.1038/nature10144

B. De-keukeleire, S. Donadio, J. Micoud, D. Lechardeur, and M. Benharouga, Human cellular prion protein hPrPC is sorted to the apical membrane of epithelial cells, Biochemical and Biophysical Research Communications, vol.354, issue.4, pp.949-954, 2007.
DOI : 10.1016/j.bbrc.2007.01.096

S. Donadio, N. Alfaidy, D. Keukeleire, B. Micoud, J. Feige et al., Expression and Localization of Cellular Prion and COMMD1 Proteins in Human Placenta throughout Pregnancy, Placenta, vol.28, issue.8-9, pp.907-918, 2007.
DOI : 10.1016/j.placenta.2006.11.006
URL : https://hal.archives-ouvertes.fr/hal-00388074

W. Feng, F. Ye, W. Xue, Z. Zhou, and Y. Kang, Copper Regulation of Hypoxia-Inducible Factor-1 Activity, Molecular Pharmacology, vol.75, issue.1, pp.174-82, 2009.
DOI : 10.1124/mol.108.051516

C. Graham, T. Hawley, R. Hawley, J. Macdougall, R. Kerbel et al., Establishment and Characterization of First Trimester Human Trophoblast Cells with Extended Lifespan, Experimental Cell Research, vol.206, issue.2, pp.204-215, 1993.
DOI : 10.1006/excr.1993.1139

F. Guillemot, A. Nagy, A. Auerbach, J. Rossant, and A. Joyner, Essential role of Mash-2 in extraembryonic development, Nature, vol.371, issue.6495, pp.333-339, 1994.
DOI : 10.1038/371333a0

C. Hancock, L. Stockwin, B. Han, R. Divelbiss, J. Jun et al., A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo, Free Radical Biology and Medicine, vol.50, issue.1, pp.110-121, 2011.
DOI : 10.1016/j.freeradbiomed.2010.10.696

P. Hoffmann, Y. Saoudi, M. Benharouga, C. Graham, J. Schaal et al., Role of EG-VEGF in human placentation: Physiological and pathological implications, Journal of Cellular and Molecular Medicine, vol.89, issue.8b, pp.2224-2259, 2009.
DOI : 10.1111/j.1582-4934.2008.00554.x
URL : https://hal.archives-ouvertes.fr/hal-01247622

H. S. Hwang, S. H. Park, Y. W. Park, H. S. Kwon, and I. S. Sohn, Expression of cellular prion protein in the placentas of women with normal and preeclamptic pregnancies, Acta Obstetricia et Gynecologica Scandinavica, vol.89, issue.9, pp.1155-1161
DOI : 10.3109/00016349.2010.498497

N. Hunkapiller, M. Gasperowicz, M. Kapidzic, V. Plaks, E. Maltepe et al., A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia, Development, vol.138, issue.14, pp.2987-98
DOI : 10.1242/dev.066589

E. Jouvin-marche, V. Attuil-audenis, C. Aude-garcia, W. Rachidi, M. Zabel et al., Overexpression of Cellular Prion Protein Induces an Antioxidant Environment Altering T Cell Development in the Thymus, The Journal of Immunology, vol.176, issue.6, pp.3490-3497, 2006.
DOI : 10.4049/jimmunol.176.6.3490
URL : https://hal.archives-ouvertes.fr/inserm-00144344

J. Kingdom and P. Kaufmann, Oxygen and Placental Vascular Development, Adv Exp Med Biol, vol.474, pp.259-75, 1999.
DOI : 10.1007/978-1-4615-4711-2_20
URL : http://doi.org/10.1007/978-1-4615-4711-2_20

F. Klamt, F. Dal-pizzol, C. Da-frota, M. , J. Walz et al., Imbalance of antioxidant defense in mice lacking cellular prion protein, Free Radical Biology and Medicine, vol.30, issue.10, pp.1137-1181, 2001.
DOI : 10.1016/S0891-5849(01)00512-3

M. Krachler, E. Rossipal, and D. Micetic-turk, Trace element transfer from the mother to the newborn ??? investigations on triplets of colostrum, maternal and umbilical cord sera, European Journal of Clinical Nutrition, vol.53, issue.6, pp.486-94, 1999.
DOI : 10.1038/sj.ejcn.1600781

J. Liang, F. Bai, G. Luo, J. Wang, J. Liu et al., Hypoxia induced overexpression of PrPC in gastric cancer cell lines, Cancer Biology & Therapy, vol.6, issue.5, pp.769-74, 2007.
DOI : 10.4161/cbt.6.5.4001

S. Lowndes, H. Sheldon, S. Cai, J. Taylor, and A. Harris, Copper chelator ATN-224 inhibits endothelial function by multiple mechanisms, Microvascular Research, vol.77, issue.3, pp.314-340, 2009.
DOI : 10.1016/j.mvr.2009.01.003

A. Martelli, Folding and turnover of human iron regulatory protein???1 depend on its subcellular localization, FEBS Journal, vol.99, issue.4, pp.1083-1092, 2007.
DOI : 10.1111/j.1742-4658.2007.05657.x
URL : https://hal.archives-ouvertes.fr/hal-00130688

N. Mclennan, P. Brennan, A. Mcneill, I. Davies, A. Fotheringham et al., Prion Protein Accumulation and Neuroprotection in Hypoxic Brain Damage, The American Journal of Pathology, vol.165, issue.1, pp.227-262, 2004.
DOI : 10.1016/S0002-9440(10)63291-9

M. Moser, R. Colello, U. Pott, and B. Oesch, Developmental expression of the prion protein gene in glial cells, Neuron, vol.14, issue.3, pp.509-526, 1995.
DOI : 10.1016/0896-6273(95)90307-0

L. Myatt, Role of Placenta in Preeclampsia, Endocrine, vol.19, issue.1, pp.103-114, 2002.
DOI : 10.1385/ENDO:19:1:103

K. Pantopoulos, Differences in the regulation of iron regulatory protein-1 (IRP-1) by extra-and intracellular oxidative stress, J Biol Chem, vol.272, pp.9802-9808, 1997.

S. Prusiner and . Prions, Nobel Lecture: Prions, Proceedings of the National Academy of Sciences, vol.95, issue.23, pp.13363-83, 1998.
DOI : 10.1073/pnas.95.23.13363

T. Raj, P. Kanellakis, G. Pomilio, G. Jennings, A. Bobik et al., Th-W60:5 Inhibition of fibroblast growth factor receptor signaling attenuates atherosclerosis in apolipoprotein E-deficient mice, Atherosclerosis Supplements, vol.7, issue.3
DOI : 10.1016/S1567-5688(06)81946-X

F. Ranjkesh, H. Jaliseh, and S. Abutorabi, Monitoring the Copper Content of Serum and Urine in Pregnancies Complicated by Preeclampsia, Biological Trace Element Research, vol.144, issue.1-3, pp.58-62, 2011.
DOI : 10.1007/s12011-011-9026-9

L. Saryan, K. Mailer, C. Krishnamurti, W. Antholine, and D. Petering, Interaction of 2-formylpyridine thiosemicarbazonato copper (II) with ehrlich ascites tumor cells, Biochemical Pharmacology, vol.30, issue.12, pp.1595-604, 1981.
DOI : 10.1016/0006-2952(81)90386-5

A. Taraboulos, A. Raeber, D. Borchelt, D. Serban, and S. Prusiner, Synthesis and trafficking of prion proteins in cultured cells., Molecular Biology of the Cell, vol.3, issue.8, pp.851-63, 1992.
DOI : 10.1091/mbc.3.8.851

A. Thackray and R. Bujdoso, Elevated PrPC Expression Predisposes to Increased HSV-1 Pathogenicity, Antiviral Chemistry and Chemotherapy, vol.100, issue.1, pp.41-52, 2006.
DOI : 10.1126/science.6801762

C. Weissmann, M. Fischer, A. Raeber, H. Bueler, A. Sailer et al., The role of PrP in pathogenesis of experimental scrapie, Cold Spring Harb Symp Quant Biol, vol.61, pp.511-533, 1996.

H. Xie and Y. Kang, Role of Copper in Angiogenesis and Its Medicinal Implications, Current Medicinal Chemistry, vol.16, issue.10, pp.1304-1318, 2009.
DOI : 10.2174/092986709787846622

S. Figure, Effect of Cu on HTR and HUVEC cells proliferation and migration. (A,B) Percentage of wound closure and number of HTR cells 24h following Cu treatments

S. Figure, Placental PrP C mRNA and protein expression throughout mouse gestation. (A) Expression of PrP C mRNAs was quantified by real-time RT-PCR, normalized to the GAPDH mRNA levels and plotted as function of gestational age (days post coï tome; 8.5, 10.5, 14.5, and 17.5) Data are expressed as mean ± SE (n=6) Values with different superscripts are significantly different from each other, ). (B) Immunolocalization of PrP C in C57 wt mice placentas. (b) and (c) correspond to successive magnifications of photograph (a)

S. Movie, HTR organization in tube-like structures under four conditions, control; siRNA to PrP C ; Cu treatment (100µM)