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Reconstitution of the entire hepatitis C virus life cycle in non-hepatic cells.: HCV life cycle in non-hepatic cells

Abstract : Hepatitis C virus (HCV) is a human hepatotropic virus, yet the relevant host factors restricting HCV infection to hepatocytes are only partially understood. We demonstrate that exogenous expression of defined host factors reconstituted the entire HCV life cycle in human non-hepatic 293T cells. This study shows robust HCV entry, RNA replication, and production of infectious virus in human non-hepatic cells, and highlights key host factors required for liver tropism of HCV.
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https://www.hal.inserm.fr/inserm-00734834
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Submitted on : Monday, September 24, 2012 - 4:10:53 PM
Last modification on : Thursday, February 21, 2019 - 4:50:02 PM
Long-term archiving on: : Monday, January 7, 2013 - 3:41:21 PM

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Daniel da Costa, Marine Turek, Daniel Felmlee, Erika Girardi, Sébastien Pfeffer, et al.. Reconstitution of the entire hepatitis C virus life cycle in non-hepatic cells.: HCV life cycle in non-hepatic cells. Journal of Virology, American Society for Microbiology, 2012, epub ahead of print. ⟨10.1128/JVI.01066-12⟩. ⟨inserm-00734834⟩

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