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Journal Articles Journal of Virology Year : 2012

Reconstitution of the entire hepatitis C virus life cycle in non-hepatic cells.

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Abstract

Hepatitis C virus (HCV) is a human hepatotropic virus, yet the relevant host factors restricting HCV infection to hepatocytes are only partially understood. We demonstrate that exogenous expression of defined host factors reconstituted the entire HCV life cycle in human non-hepatic 293T cells. This study shows robust HCV entry, RNA replication, and production of infectious virus in human non-hepatic cells, and highlights key host factors required for liver tropism of HCV.

Domains

Life Sciences [q-bio] Human health and pathology Hépatology and Gastroenterology
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https://www.hal.inserm.fr/inserm-00734834

Submitted on : Monday, September 24, 2012-4:10:53 PM

Last modification on : Wednesday, May 5, 2021-10:50:02 AM

Long-term archiving on: Monday, January 7, 2013-3:41:21 PM

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inserm-00734834 , version 1 (24-09-2012)

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Daniel da Costa, Marine Turek, Daniel J. Felmlee, Erika Girardi, Sébastien Pfeffer, et al.. Reconstitution of the entire hepatitis C virus life cycle in non-hepatic cells.: HCV life cycle in non-hepatic cells. Journal of Virology, 2012, epub ahead of print. ⟨10.1128/JVI.01066-12⟩. ⟨inserm-00734834⟩

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