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Journal articles
Reconstitution of the entire hepatitis C virus life cycle in non-hepatic cells.: HCV life cycle in non-hepatic cells
Abstract : Hepatitis C virus (HCV) is a human hepatotropic virus, yet the relevant host factors restricting HCV infection to hepatocytes are only partially understood. We demonstrate that exogenous expression of defined host factors reconstituted the entire HCV life cycle in human non-hepatic 293T cells. This study shows robust HCV entry, RNA replication, and production of infectious virus in human non-hepatic cells, and highlights key host factors required for liver tropism of HCV.
https://www.hal.inserm.fr/inserm-00734834
Contributor : Thomas F. Baumert <>
Submitted on : Monday, September 24, 2012 - 4:10:53 PM
Last modification on : Thursday, November 26, 2020 - 3:56:04 PM
Long-term archiving on: : Monday, January 7, 2013 - 3:41:21 PM
Contributor : Thomas F. Baumert <>
Submitted on : Monday, September 24, 2012 - 4:10:53 PM
Last modification on : Thursday, November 26, 2020 - 3:56:04 PM
Long-term archiving on: : Monday, January 7, 2013 - 3:41:21 PM
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