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Biodiversity as a barrier to glioma cell invasion.

Abstract : Gliomas are extremely aggressive and lethal forms of brain cancer. Unlike many other cancer types, glioma cells rarely metastasize. They spread throughout the brain and invasiveness of glioma cells is a major cause of therapeutic failure. In plant ecosystem, biodiversity acts locally as a barrier to ecological invasion. By analogy, we hypothesize that the low cell diversity of differentiated tissues, a counterpart of their functional specificity, opens the way to local cancer cell invasion. Seeding the brain tumor microenvironment with heterogeneous cell populations could be a mean to limit cancer cell invasion by enhancing cell biodiversity.
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https://www.hal.inserm.fr/inserm-00733968
Contributor : Jean-Paul Issartel <>
Submitted on : Thursday, September 20, 2012 - 12:04:15 PM
Last modification on : Monday, April 20, 2020 - 3:52:04 PM
Long-term archiving on: : Friday, December 21, 2012 - 3:49:52 AM

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Laurent Selek, Franck Mauconduit, Marie-France Nissou, Guillaume Nugue, Hana Lahrech, et al.. Biodiversity as a barrier to glioma cell invasion.. Medical Hypotheses, Elsevier, 2012, 78 (4), pp.459-61. ⟨10.1016/j.mehy.2012.01.005⟩. ⟨inserm-00733968⟩

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