Biodiversity as a barrier to glioma cell invasion. - Archive ouverte HAL Access content directly
Journal Articles Medical Hypotheses Year : 2012

Biodiversity as a barrier to glioma cell invasion.

(1) , (2) , (2) , (2) , (2) , (3) , (4) , (2)
1
2
3
4

Abstract

Gliomas are extremely aggressive and lethal forms of brain cancer. Unlike many other cancer types, glioma cells rarely metastasize. They spread throughout the brain and invasiveness of glioma cells is a major cause of therapeutic failure. In plant ecosystem, biodiversity acts locally as a barrier to ecological invasion. By analogy, we hypothesize that the low cell diversity of differentiated tissues, a counterpart of their functional specificity, opens the way to local cancer cell invasion. Seeding the brain tumor microenvironment with heterogeneous cell populations could be a mean to limit cancer cell invasion by enhancing cell biodiversity.
Fichier principal
Vignette du fichier
Selek_2012_Biodiversity_MA.pdf (170.2 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

inserm-00733968 , version 1 (20-09-2012)

Identifiers

Cite

Laurent Selek, Franck Mauconduit, Marie-France Nissou, Guillaume Nugue, Hana Lahrech, et al.. Biodiversity as a barrier to glioma cell invasion.. Medical Hypotheses, 2012, 78 (4), pp.459-61. ⟨10.1016/j.mehy.2012.01.005⟩. ⟨inserm-00733968⟩

Collections

INSERM UGA U836
179 View
304 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More