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Cortical dysplasia: a possible substrate for brain tumors.

Abstract : The similarities between brain tumor stem cells and neural stem cells suggest a possible stem cell origin of tumorigenesis. Recently, cells with features of stem cells have been observed in lesions of adult and pediatric cortical dysplasia (CD). Given the evidence for a close relationship between CD and certain brain tumors, together with the finding that CD neural stem cells/progenitors are abnormally developed, we propose that CD is a possible substrate for brain tumors. The neural stem cells/progenitors in CD have accumulating abnormalities, and these abnormal stem/progenitor cells may be the initiating, transformed cells of brain tumors, when subsequently exposed to a carcinogen.
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https://www.hal.inserm.fr/inserm-00733963
Contributor : Jean-Paul Issartel <>
Submitted on : Thursday, September 20, 2012 - 11:52:35 AM
Last modification on : Tuesday, February 12, 2019 - 4:34:02 PM
Long-term archiving on: : Friday, December 16, 2016 - 3:40:09 PM

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Shiyong Liu, Chunqing Zhang, Haifeng Shu, Didier Wion, Hui Yang. Cortical dysplasia: a possible substrate for brain tumors.. Future Oncology, Future Medicine, 2012, 8 (3), pp.251-8. ⟨10.2217/fon.12.6⟩. ⟨inserm-00733963⟩

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