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Journal articles
Cortical dysplasia: a possible substrate for brain tumors.
Abstract : The similarities between brain tumor stem cells and neural stem cells suggest a possible stem cell origin of tumorigenesis. Recently, cells with features of stem cells have been observed in lesions of adult and pediatric cortical dysplasia (CD). Given the evidence for a close relationship between CD and certain brain tumors, together with the finding that CD neural stem cells/progenitors are abnormally developed, we propose that CD is a possible substrate for brain tumors. The neural stem cells/progenitors in CD have accumulating abnormalities, and these abnormal stem/progenitor cells may be the initiating, transformed cells of brain tumors, when subsequently exposed to a carcinogen.
Cited literature [44 references]
https://www.hal.inserm.fr/inserm-00733963
Contributor : Jean-Paul Issartel <>
Submitted on : Thursday, September 20, 2012 - 11:52:35 AM
Last modification on : Wednesday, May 5, 2021 - 9:38:03 AM
Long-term archiving on: : Friday, December 16, 2016 - 3:40:09 PM
Contributor : Jean-Paul Issartel <>
Submitted on : Thursday, September 20, 2012 - 11:52:35 AM
Last modification on : Wednesday, May 5, 2021 - 9:38:03 AM
Long-term archiving on: : Friday, December 16, 2016 - 3:40:09 PM