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Cortical dysplasia: a possible substrate for brain tumors.

Shiyong Liu 1 Chunqing Zhang 1 Haifeng Shu 1 Didier Wion 2 Hui yang 1, * 
* Corresponding author
2 Inserm U836, équipe 7, Nanomédecine et cerveau
GIN - Grenoble Institut des Neurosciences
Abstract : The similarities between brain tumor stem cells and neural stem cells suggest a possible stem cell origin of tumorigenesis. Recently, cells with features of stem cells have been observed in lesions of adult and pediatric cortical dysplasia (CD). Given the evidence for a close relationship between CD and certain brain tumors, together with the finding that CD neural stem cells/progenitors are abnormally developed, we propose that CD is a possible substrate for brain tumors. The neural stem cells/progenitors in CD have accumulating abnormalities, and these abnormal stem/progenitor cells may be the initiating, transformed cells of brain tumors, when subsequently exposed to a carcinogen.
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Submitted on : Thursday, September 20, 2012 - 11:52:35 AM
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Shiyong Liu, Chunqing Zhang, Haifeng Shu, Didier Wion, Hui yang. Cortical dysplasia: a possible substrate for brain tumors.. Future Oncology, Future Medicine, 2012, 8 (3), pp.251-8. ⟨10.2217/fon.12.6⟩. ⟨inserm-00733963⟩



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