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Journal Articles Future Oncology Year : 2012

Cortical dysplasia: a possible substrate for brain tumors.

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Abstract

The similarities between brain tumor stem cells and neural stem cells suggest a possible stem cell origin of tumorigenesis. Recently, cells with features of stem cells have been observed in lesions of adult and pediatric cortical dysplasia (CD). Given the evidence for a close relationship between CD and certain brain tumors, together with the finding that CD neural stem cells/progenitors are abnormally developed, we propose that CD is a possible substrate for brain tumors. The neural stem cells/progenitors in CD have accumulating abnormalities, and these abnormal stem/progenitor cells may be the initiating, transformed cells of brain tumors, when subsequently exposed to a carcinogen.
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inserm-00733963 , version 1 (20-09-2012)

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Shiyong Liu, Chunqing Zhang, Haifeng Shu, Didier Wion, Hui Yang. Cortical dysplasia: a possible substrate for brain tumors.. Future Oncology, 2012, 8 (3), pp.251-8. ⟨10.2217/fon.12.6⟩. ⟨inserm-00733963⟩

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