Clonal analysis of oligodendrocyte development in culture: Evidence for a developmental clock that counts cell divisions, Cell, vol.44, issue.5, pp.773-779, 1986. ,
DOI : 10.1016/0092-8674(86)90843-3
Proliferating bipotential glial progenitor cells in adult rat optic nerve, Nature, vol.55, issue.6053, pp.499-502, 1986. ,
DOI : 10.1038/319499a0
Oligodendroglial progenitors labeled with the O4 antibody persist in the adult rat cerebral cortex in vivo, Journal of Neuroscience Research, vol.116, issue.5, pp.455-470, 1997. ,
DOI : 10.1002/(SICI)1097-4547(19970301)47:5<455::AID-JNR1>3.0.CO;2-G
Identification of an adult-specific glial progenitor cell, Cell Differentiation and Development, vol.27, pp.387-400, 1989. ,
DOI : 10.1016/0922-3371(89)90618-7
TheYin andYang of cell cycle progression and differentiation in the oligodendroglial lineage, Mental Retardation and Developmental Disabilities Research Reviews, vol.25, issue.2, pp.85-96, 2006. ,
DOI : 10.1002/mrdd.20103
Postnatal Neurogenesis and Gliogenesis in the Olfactory Bulb from NG2-Expressing Progenitors of the Subventricular Zone, Journal of Neuroscience, vol.24, issue.46, pp.10530-10541, 2004. ,
DOI : 10.1523/JNEUROSCI.3572-04.2004
Postnatal NG2 proteoglycan???expressing progenitor cells are intrinsically multipotent and generate functional neurons, The Journal of Cell Biology, vol.125, issue.1, pp.169-186, 2003. ,
DOI : 10.1073/pnas.232586699
Oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells derived from adult rat spinal cord: In vitro characteristics and response to PDGF, bFGF and NT-3, Glia, vol.116, issue.1, pp.16-26, 1996. ,
DOI : 10.1002/(SICI)1098-1136(199601)16:1<16::AID-GLIA3>3.0.CO;2-9
Oligodendrocyte Precursor Cells Reprogrammed to Become Multipotential CNS Stem Cells, Science, vol.289, issue.5485, pp.1754-1757, 2000. ,
DOI : 10.1126/science.289.5485.1754
PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice, Nature Neuroscience, vol.22, issue.12, pp.1392-1401, 2008. ,
DOI : 10.1523/JNEUROSCI.0476-07.2007
Mixed primary culture and clonal analysis provide evidence that NG2 proteoglycan-expressing cells after spinal cord injury are glial progenitors, Developmental Neurobiology, vol.50, issue.7, pp.860-874, 2007. ,
DOI : 10.1002/dneu.20369
A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development, Development, vol.120, pp.1097-1108, 1994. ,
NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions, J Neurosci, vol.20, pp.6404-6412, 2000. ,
Why does remyelination fail in multiple sclerosis?, Nature Reviews Neuroscience, vol.105, issue.9, pp.705-714, 2002. ,
DOI : 10.1038/nrn917
Endogenous Progenitors Remyelinate Demyelinated Axons in the Adult CNS, Neuron, vol.19, issue.1, pp.197-203, 1997. ,
DOI : 10.1016/S0896-6273(00)80359-1
Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain, Cell, vol.97, issue.6, pp.703-716, 1999. ,
DOI : 10.1016/S0092-8674(00)80783-7
Both oligodendrocytes and astrocytes develop from progenitors in the subventricular zone of postnatal rat forebrain, Neuron, vol.10, issue.2, pp.201-212, 1993. ,
DOI : 10.1016/0896-6273(93)90311-E
Progenitor cells of the adult mouse subventricular zone proliferate, migrate and differentiate into oligodendrocytes after demyelination, European Journal of Neuroscience, vol.4, issue.12, pp.4357-4366, 1999. ,
DOI : 10.1046/j.1460-9568.1999.00873.x
Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice, Proceedings of the National Academy of Sciences, vol.99, issue.20, pp.13211-13216, 2002. ,
DOI : 10.1073/pnas.192314199
Activation of the subventricular zone in multiple sclerosis: Evidence for early glial progenitors, Proceedings of the National Academy of Sciences, vol.104, issue.11, pp.4694-4699, 2007. ,
DOI : 10.1073/pnas.0606835104
Growth factor treatment promotes mobilization of young but not aged adult subventricular zone precursors in response to demyelination, Journal of Neuroscience Research, vol.92, issue.6, pp.763-771, 2002. ,
DOI : 10.1002/jnr.10411
Origin of Oligodendrocytes in the Subventricular Zone of the Adult Brain, Journal of Neuroscience, vol.26, issue.30, pp.7907-7918, 2006. ,
DOI : 10.1523/JNEUROSCI.1299-06.2006
A functional role for EGFR signaling in myelination and remyelination, Nature Neuroscience, vol.22, issue.8, pp.990-1002, 2007. ,
DOI : 10.1046/j.0305-1846.2001.00301.x
CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors, Annual Review of Cell and Developmental Biology, vol.13, issue.1, pp.261-291, 1997. ,
DOI : 10.1146/annurev.cellbio.13.1.261
CDK inhibitors: positive and negative regulators of G1-phase progression, Genes & Development, vol.13, issue.12, pp.1501-1512, 1999. ,
DOI : 10.1101/gad.13.12.1501
p27Kip1 and p21Cip1 Are Not Required for the Formation of Active D Cyclin-cdk4 Complexes, Molecular and Cellular Biology, vol.23, issue.20, pp.7285-7290, 2003. ,
DOI : 10.1128/MCB.23.20.7285-7290.2003
Activation of cyclin D1-kinase in murine fibroblasts lacking both p21Cip1 and p27Kip1, Oncogene, vol.21, issue.53, pp.8067-8074, 2002. ,
DOI : 10.1038/sj.onc.1206019
New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment?, Trends in Cell Biology, vol.13, issue.2, pp.65-70, 2003. ,
DOI : 10.1016/S0962-8924(02)00043-0
Cyclin-dependent kinase-2 controls oligodendrocyte progenitor cell cycle progression and is downregulated in adult oligodendrocyte progenitors, J Neurosci, vol.22, pp.8553-8562, 2002. ,
Cdk2 loss accelerates precursor differentiation and remyelination in the adult central nervous system, The Journal of Cell Biology, vol.105, issue.2, pp.397-407, 2011. ,
DOI : 10.1016/S0896-6273(00)80898-3
Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation, Development, vol.126, pp.4027-4037, 1999. ,
Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor??p27Kip1, Genes & Development, vol.11, issue.18, pp.2335-2346, 1997. ,
DOI : 10.1101/gad.11.18.2335
Inhibition of cyclin E-cyclin-dependent kinase 2 complex formation and activity is associated with cell cycle arrest and withdrawal in oligodendrocyte progenitor cells, pp.1274-1282, 2001. ,
Neurotransmitter receptor activation triggers p27(Kip1) and p21(CIP1) accumulation and G1 cell cycle arrest in oligodendrocyte progenitors, pp.1077-1090, 1999. ,
Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture, Nature, vol.333, issue.6173, pp.562-565, 1988. ,
DOI : 10.1038/333562a0
Ectopic expression of p27Kip1 in oligodendrocyte progenitor cells results in cell-cycle growth arrest, Journal of Neurobiology, vol.272, issue.3, pp.431-440, 1998. ,
DOI : 10.1002/(SICI)1097-4695(19980905)36:3<431::AID-NEU10>3.0.CO;2-E
Cdk2 Knockout Mice Are Viable, Current Biology, vol.13, issue.20, pp.1775-1785, 2003. ,
DOI : 10.1016/j.cub.2003.09.024
Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice, Nature Genetics, vol.35, issue.1, pp.25-31, 2003. ,
DOI : 10.1038/ng1232
Cdk2 is critical for proliferation and self-renewal of neural progenitor cells in the adult subventricular zone, The Journal of Cell Biology, vol.8, issue.6, pp.1231-1245, 2007. ,
DOI : 10.1093/embo-reports/kve008
Proliferation of cancer cells despite CDK2 inhibition, Cancer Cell, vol.3, issue.3, pp.233-245, 2003. ,
DOI : 10.1016/S1535-6108(03)00053-9
Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms, Oncogene, vol.16, issue.33, pp.2925-2939, 2009. ,
DOI : 10.1016/0006-291X(92)91851-G
Mammalian Cells Cycle without the D-Type Cyclin-Dependent Kinases Cdk4 and Cdk6, Cell, vol.118, issue.4, pp.493-504, 2004. ,
DOI : 10.1016/j.cell.2004.08.002
Cdc2???cyclin E complexes regulate the G1/S phase transition, Nature Cell Biology, vol.14, issue.8, pp.831-836, 2005. ,
DOI : 10.1016/0022-1759(94)90396-4
Genetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2, Development, vol.135, issue.20, pp.3389-3400, 2008. ,
DOI : 10.1242/dev.024919
CDK2 is Dispensable for Adult Hippocampal Neurogenesis, Cell Cycle, vol.6, issue.24, pp.3065-3069, 2007. ,
DOI : 10.4161/cc.6.24.5048
Reconstitution of a developmental clock in vitro: a critical role for astrocytes in the timing of oligodendrocyte differentiation, Cell, vol.42, issue.1, pp.61-69, 1985. ,
DOI : 10.1016/S0092-8674(85)80101-X
Posttranscriptional Regulation of p18 and p27 Cdk Inhibitor Proteins and the Timing of Oligodendrocyte Differentiation, Developmental Biology, vol.245, issue.1, pp.224-234, 2002. ,
DOI : 10.1006/dbio.2002.0626
The complexity of p53 modulation: emerging patterns from divergent signals, Genes & Development, vol.12, issue.19, pp.2973-2983, 1998. ,
DOI : 10.1101/gad.12.19.2973
p53 plays a regulatory role in differentiation and apoptosis of central nervous system-associated cells., Molecular and Cellular Biology, vol.16, issue.9, pp.535178-5185, 1996. ,
DOI : 10.1128/MCB.16.9.5178
Inhibitors of mammalian G1 cyclin-dependent kinases., Genes & Development, vol.9, issue.10, pp.1149-1163, 1995. ,
DOI : 10.1101/gad.9.10.1149
p27Kip1 alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation, Current Biology, vol.8, issue.8, pp.27-1431, 1998. ,
DOI : 10.1016/S0960-9822(98)70177-0
Accumulation of the cyclin-dependent kinase inhibitor p27/Kip1 and the timing of oligodendrocyte differentiation, The EMBO Journal, vol.16, issue.2, pp.306-317, 1997. ,
DOI : 10.1093/emboj/16.2.306
Voltage-activated K + channels and membrane depolarization regulate accumulation of the cyclin-dependent kinase inhibitors p27(Kip1) and p21(CIP1) in glial progenitor cells, J Neurosci, vol.19, pp.5380-5392, 1999. ,
Changes in the activity of cdk2 and cdk5 accompany differentiation of rat primary oligodendrocytes, Journal of Cellular Biochemistry, vol.183, issue.1, pp.128-137, 1998. ,
DOI : 10.1002/(SICI)1097-4644(19980101)68:1<128::AID-JCB13>3.0.CO;2-D
Changes in cyclindependent kinase 2 and p27kip1 accompany glial cell differentiation of central glia-4 cells, J Biol Chem, vol.272, pp.442-447, 1997. ,
Cell cycle arrest induced by ectopic expression of p27 is not sufficient to promote oligodendrocyte differentiation, Journal of Cellular Biochemistry, vol.40, issue.2, pp.270-279, 1999. ,
DOI : 10.1002/(SICI)1097-4644(20000201)76:2<270::AID-JCB10>3.0.CO;2-6
Precursor Cell Transitions in Oligodendrocyte Development, The Journal of Cell Biology, vol.109, issue.5, pp.839-842, 2000. ,
DOI : 10.1083/jcb.116.1.167
Unraveling Oligodendrocyte Origin and Function by Cell-Specific Transgenesis, Developmental Neuroscience, vol.23, issue.4-5, pp.287-298, 2001. ,
DOI : 10.1159/000048712
Expression of the green fluorescent protein in the oligodendrocyte lineage: A transgenic mouse for developmental and physiological studies, Journal of Neuroscience Research, vol.25, issue.4, pp.529-545, 2002. ,
DOI : 10.1002/jnr.10368
A quantitative study of morphological changes accompanying the initiation and progress of myelin production in the dorsal funiculus of the rat spinal cord, The Journal of Comparative Neurology, vol.21, issue.1, pp.1-22, 1971. ,
DOI : 10.1002/cne.901420102
Myelin basic protein: a multifunctional protein, Cellular and Molecular Life Sciences, vol.63, issue.17, pp.1945-1961, 2006. ,
DOI : 10.1007/s00018-006-6094-7
Progeny of Olig2-Expressing Progenitors in the Gray and White Matter of the Adult Mouse Cerebral Cortex, Journal of Neuroscience, vol.28, issue.41, pp.10434-10442, 2008. ,
DOI : 10.1523/JNEUROSCI.2831-08.2008
Premyelinating Oligodendrocytes in Chronic Lesions of Multiple Sclerosis, New England Journal of Medicine, vol.346, issue.3, pp.165-173, 2002. ,
DOI : 10.1056/NEJMoa010994
Persistent inflammation alters the function of the endogenous brain stem cell compartment, Brain, vol.131, issue.10, pp.2564-2578, 2008. ,
DOI : 10.1093/brain/awn198
Combined Loss of Cdk2 and Cdk4 Results in Embryonic Lethality and Rb Hypophosphorylation, Developmental Cell, vol.10, issue.5, pp.563-573, 2006. ,
DOI : 10.1016/j.devcel.2006.03.004
The origin and development of glial cells in peripheral nerves, Nature Reviews Neuroscience, vol.109, issue.9, pp.671-682, 2005. ,
DOI : 10.1006/mcne.1996.0589
Postnatal Schwann cell proliferation but not myelination is strictly and uniquely dependent on cyclin-dependent kinase 4 (cdk4), Molecular and Cellular Neuroscience, vol.37, issue.3, pp.519-527, 2008. ,
DOI : 10.1016/j.mcn.2007.11.005
Hypoxia Alters Cell Cycle Regulatory Protein Expression and Induces Premature Maturation of Oligodendrocyte Precursor Cells, PLoS ONE, vol.126, issue.3, p.4739, 2009. ,
DOI : 10.1371/journal.pone.0004739.g013
Cyclin A/cdk2 Activation Is Involved in Hypoxia-Induced Apoptosis in Cardiomyocytes, Circulation Research, vol.88, issue.4, pp.408-414, 2001. ,
DOI : 10.1161/01.RES.88.4.408
Ionizing radiation induces apoptosis and elevates cyclin A1-Cdk2 activity before but not after the midblastula transition in Xenopus., Molecular Biology of the Cell, vol.8, issue.7, pp.1195-1206, 1997. ,
DOI : 10.1091/mbc.8.7.1195
Caspase-Dependent Cdk Activity Is a Requisite Effector of Apoptotic Death Events, The Journal of Cell Biology, vol.12, issue.1, pp.59-72, 2000. ,
DOI : 10.1016/S0092-8674(00)80501-2
Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells, Proceedings of the National Academy of Sciences, vol.95, issue.12, pp.6785-6790, 1998. ,
DOI : 10.1073/pnas.95.12.6785
Inhibition of Hypoxia-Induced Apoptosis by Modulation of Retinoblastoma Protein-Dependent Signaling in Cardiomyocytes, Circulation Research, vol.91, issue.9, pp.782-789, 2002. ,
DOI : 10.1161/01.RES.0000041030.98642.41
Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death, J Neurosci, vol.21, pp.5045-5053, 2001. ,
The Cyclin-dependent Kinase Cdk2 Regulates Thymocyte Apoptosis, The Journal of Experimental Medicine, vol.265, issue.6, pp.957-968, 1999. ,
DOI : 10.1023/A:1026358821640
Immunoreactivity of Cyclin D1/cdk4 in Neurons and Oligodendrocytes After Focal Cerebral Ischemia in Rat, Journal of Cerebral Blood Flow & Metabolism, vol.20, issue.8, pp.846-856, 1997. ,
DOI : 10.1097/00004647-199708000-00003
Cell cycle-related gene expression in the adult rat brain: Selective induction of cyclin G1 and p21WAF1/CIP1 in neurons following focal cerebral ischemia, Neuroscience, vol.84, issue.4, pp.1097-1112, 1998. ,
DOI : 10.1016/S0306-4522(97)00580-0
Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury, Journal of Molecular and Cellular Cardiology, vol.45, issue.5, pp.610-616, 2008. ,
DOI : 10.1016/j.yjmcc.2008.07.003
Gene profiling in spinal cord injury shows role of cell cycle in neuronal death, Annals of Neurology, vol.490, issue.4, pp.454-468, 2003. ,
DOI : 10.1002/ana.10472
Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury, Proceedings of the National Academy of Sciences, vol.102, issue.23, pp.8333-8338, 2005. ,
DOI : 10.1073/pnas.0500989102
Neuroprotective effects of novel small peptides in vitro and after brain injury, Neuropharmacology, vol.49, issue.3, pp.410-424, 2005. ,
DOI : 10.1016/j.neuropharm.2005.04.001
Cell Cycle Activation and Spinal Cord Injury, Neurotherapeutics, vol.127, issue.2, pp.221-228, 2011. ,
DOI : 10.1007/s13311-011-0028-2
Temporal and Spatial Expression of Cyclin H in Rat Spinal Cord Injury, NeuroMolecular Medicine, vol.16, issue.Pt 3, pp.187-196, 2011. ,
DOI : 10.1007/s12017-011-8150-1