Arterial Spin Labeling at 3T in semantic dementia: perfusion abnormalities detection and comparison with FDG-PET

Abstract : Arterial Spin Labeling (ASL) is a non invasive perfusion imaging technique which has shown great diagnosis potential in dementia. However, it has never been applied to semantic dementia (SD), a rare subtype of frontotemporal lobar degeneration characterized by the gradual loss of conceptual knowledge, which is actually explored by a now well established marker of SD: 18fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging. Although ASL and FDG-PET respectively measure perfusion and metabolism, they have been shown to be strongly correlated. We propose to explore the ability of ASL to detect perfusion abnormalities in SD in comparison with FDG-PET. Using patients and healthy subjects data from an ongoing clinical study, we apply our analysis framework starting with visual comparison of ASL and FDG-PET, and focusing on ASL data preprocessing and statistical analysis at the individual and group level. Preliminary results yield concordant observations between ASL and FDG-PET as well as expected hypoperfusions in SD, namely in the left temporal lobe, thus suggesting the potential of ASL to assess perfusion impairments in SD.