Age effect on the default mode network, inner thoughts, and cognitive abilities.

Katell Mevel 1, * Brigitte Landeau 1 Marine Fouquet 1 Renaud La Joie 1 Nicolas Villain 1 Florence Mézenge 1 Audrey Perrotin 1 Francis Eustache 1 Beatrice Desgranges 1 Gaël Chételat 1
* Auteur correspondant
1 Neuropsychologie cognitive et neuroanatomie fonctionnelles de la mémoire humaine
Abstract : Age-related effects on the default mode network (DMN) connectivity as measured at rest using functional magnetic resonance imaging (fMRI) are now well described. Little is known however about the relationships between these changes and age-related effects on cognition or on the unconstrained thoughts which occur during the resting-state scan, called inner experience. Brain resting-state activity, inner experience, and cognitive ability measurements were obtained in 70 participants aged 19-80 years. The anterior-posterior disruption of DMN activity with age reported in previous studies was recovered here. A significant effect of age was also found on cognitive abilities but not on inner experience. Finally, age-related changes in DMN connectivity were found to correlate with cognitive abilities, and more specifically with autobiographical memory performance. These findings provide new information to fuel the debate on the role of the brain default mode and more specifically on the effect of age-related changes in resting-state activity as measured with fMRI.
Keywords : aging resting state default mode network functional connectivity autobiographical memory inner experience
Type de document :
Article dans une revue
Neurobiology of Aging, Elsevier, 2013, 34 (4), pp.1292-301. 〈10.1016/j.neurobiolaging.2012.08.018〉
Liste complète des métadonnées

Littérature citée [39 références]  Voir  Masquer  Télécharger
http://www.hal.inserm.fr/inserm-00729080
Contributeur : Francis Eustache <>
Soumis le : vendredi 7 septembre 2012 - 14:50:29
Dernière modification le : mercredi 6 juin 2018 - 01:24:10
Document(s) archivé(s) le : samedi 8 décembre 2012 - 03:41:53

Fichiers

Revised_RegularArticle_Mevel_H...
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

PSL | COMUE-NORMANDIE

Citation

Katell Mevel, Brigitte Landeau, Marine Fouquet, Renaud La Joie, Nicolas Villain, et al.. Age effect on the default mode network, inner thoughts, and cognitive abilities.. Neurobiology of Aging, Elsevier, 2013, 34 (4), pp.1292-301. 〈10.1016/j.neurobiolaging.2012.08.018〉. 〈inserm-00729080〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

302

Téléchargements de fichiers

368

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD