Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, Epiciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Age effect on the default mode network, inner thoughts, and cognitive abilities.

Abstract : Age-related effects on the default mode network (DMN) connectivity as measured at rest using functional magnetic resonance imaging (fMRI) are now well described. Little is known however about the relationships between these changes and age-related effects on cognition or on the unconstrained thoughts which occur during the resting-state scan, called inner experience. Brain resting-state activity, inner experience, and cognitive ability measurements were obtained in 70 participants aged 19-80 years. The anterior-posterior disruption of DMN activity with age reported in previous studies was recovered here. A significant effect of age was also found on cognitive abilities but not on inner experience. Finally, age-related changes in DMN connectivity were found to correlate with cognitive abilities, and more specifically with autobiographical memory performance. These findings provide new information to fuel the debate on the role of the brain default mode and more specifically on the effect of age-related changes in resting-state activity as measured with fMRI.
Document type :
Journal articles
Complete list of metadata

Cited literature [39 references]  Display  Hide  Download
Contributor : Francis Eustache Connect in order to contact the contributor
Submitted on : Friday, September 7, 2012 - 2:50:29 PM
Last modification on : Wednesday, November 17, 2021 - 12:32:00 PM
Long-term archiving on: : Saturday, December 8, 2012 - 3:41:53 AM


Files produced by the author(s)




Katell Mevel, Brigitte Landeau, Marine Fouquet, Renaud La Joie, Nicolas Villain, et al.. Age effect on the default mode network, inner thoughts, and cognitive abilities.. Neurobiology of Aging, Elsevier, 2013, 34 (4), pp.1292-301. ⟨10.1016/j.neurobiolaging.2012.08.018⟩. ⟨inserm-00729080⟩



Record views


Files downloads