Interictal spikes, fast ripples and seizures in partial epilepsies - combining multi-level computational models with experimental data.: computational and experimental models of epilepsy

Fabrice Wendling 1, * Fabrice Bartolomei 2, 3 Faten Mina 1 Clémént Huneau 1 Pascal Benquet 1
* Auteur correspondant
1 LTSI - Laboratoire Traitement du Signal et de l'Image
2 Service de Neurophysiologie Clinique
3 Epilepsies, Lesions Cerebrales et Systemes Neuraux de la Cognition
Abstract : Epileptic seizures, epileptic spikes and high-frequency oscillations (HFOs) are recognized as three electrophysiological markers of epileptogenic neuronal systems. It can be reasonably hypothesized that distinct (hyper)excitability mechanisms underlie these electrophysiological signatures. The question is 'What are these mechanisms?'. Solving this difficult question would considerably help our understanding of epileptogenic processes and would also advance our interpretation of electrophysiological signals. In this paper, we show how computational models of brain epileptic activity can be used to address this issue. With a special emphasis on the hippocampal activity recorded in various experimental models (in vivo and in vitro) as well as in epileptic patients, we confront results and insights we can get from computational models lying at two different levels of description, namely macroscopic (neural mass) and microscopic (detailed network of neurons). At each level, we show how spikes, seizures and HFOs can (or cannot) be generated depending on the model features. The replication of observed signals, the prediction of possible mechanisms as well as their experimental validation are described and discussed; as are the advantages and limitations of the two modelling approaches.
Keywords : epilepsy models computational in vivo in vitro interictal spikes fast ripples seizures
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Article dans une revue
European Journal of Neuroscience, Wiley, 2012, 36 (2), pp.2164-77. 〈10.1111/j.1460-9568.2012.08039.x〉
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Fabrice Wendling, Fabrice Bartolomei, Faten Mina, Clémént Huneau, Pascal Benquet. Interictal spikes, fast ripples and seizures in partial epilepsies - combining multi-level computational models with experimental data.: computational and experimental models of epilepsy. European Journal of Neuroscience, Wiley, 2012, 36 (2), pp.2164-77. 〈10.1111/j.1460-9568.2012.08039.x〉. 〈inserm-00728701〉

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