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Functional arterial spin labeling: Optimal sequence duration for motor activation mapping in clinical practice.

Hélène Raoult 1, 2 Jean-Christophe Ferré 1, 2, 3 Jan Petr 1, 4 Elise Bannier 3 Aymeric Stamm 1 Christian Barillot 1, 3 Jean-yves Gauvrit 1, 2, 3 
1 VisAGeS - Vision, Action et Gestion d'informations en Santé
INSERM - Institut National de la Santé et de la Recherche Médicale : U746, Inria Rennes – Bretagne Atlantique , IRISA-D5 - SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE
Abstract : PURPOSE: To determine the minimal optimal functional arterial spin labeling (fASL) sequence duration allowing steady and reproducible motor activation mapping. MATERIALS AND METHODS: Three magnetic resonance imaging (MRI) sessions including fASL and blood oxygenation level-dependent (BOLD) functional MRI (fMRI) sequences were performed on 12 healthy subjects at 3T with a 32-channel coil. The raw 7-minute fASL sequence was truncated to obtain six fASL sequences with durations ranging from 1-6 minutes. All the resulting fASL activations were compared between themselves and with both the 7-minute fASL and BOLD activations. Quantitative parameters assessed activation location (activated volume, barycenter, and distance between barycenters), activation quantification (activation-related cerebral blood flow), and intraindividual reproducibility across fMRI sessions. The statistical analysis was based on analysis of variance (ANOVA) and Tukey's multiple comparisons. RESULTS: Four-minute fASL achieved steady location and quantification of activation with the activated volume corresponding to 81% of the 7-minute fASL volume and a barycenter located 1.2 mm from the 7-minute fASL barycenter and 3.0 mm from the BOLD fMRI barycenter. Four-minute fASL reproducibility was high and statistically equivalent to 7-minute values. CONCLUSION: A 4-minute fASL sequence is thus a reliable tool for motor activation mapping and suitable for use in clinical practice.
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Submitted on : Tuesday, September 4, 2012 - 3:33:38 PM
Last modification on : Wednesday, February 2, 2022 - 3:55:03 PM

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Hélène Raoult, Jean-Christophe Ferré, Jan Petr, Elise Bannier, Aymeric Stamm, et al.. Functional arterial spin labeling: Optimal sequence duration for motor activation mapping in clinical practice.. Journal of Magnetic Resonance Imaging, Wiley-Blackwell, 2012, 36 (6), pp.1435-44. ⟨10.1002/jmri.23782⟩. ⟨inserm-00727889⟩



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