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The different faces of Notch in T-helper-cell differentiation, Nature Reviews Immunology, vol.204, issue.2, pp.116-124, 2009. ,
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Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-??, Journal of Clinical Investigation, vol.116, issue.4, pp.996-1004, 2006. ,
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Jagged2-Expressing Hematopoietic Progenitors Promote Regulatory T Cell Expansion in the Periphery through Notch Signaling, Immunity, vol.25, issue.5, pp.823-834, 2006. ,
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Expression of Activated Notch3 in Transgenic Mice Enhances Generation of T Regulatory Cells and Protects against Experimental Autoimmune Diabetes, The Journal of Immunology, vol.171, issue.9, pp.4504-4511, 2003. ,
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Cross-talk between the Notch and TGF-?? signaling pathways mediated by interaction of the Notch intracellular domain with Smad3, The Journal of Cell Biology, vol.124, issue.4, pp.723-728, 2003. ,
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TGF-??, T-cell tolerance and immunotherapy of autoimmune diseases and cancer, Expert Review of Clinical Immunology, vol.2, issue.2, pp.257-265, 2006. ,
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HES-1 Repression of Differentiation and Proliferation in PC12 Cells: Role for the Helix 3-Helix 4 Domain in Transcription Repression, Molecular and Cellular Biology, vol.20, issue.16, pp.6170-6183, 2000. ,
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TGF-?? signaling is required for the function of insulin-reactive T regulatory cells, Journal of Clinical Investigation, vol.116, issue.5, pp.1360-1370, 2006. ,
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A Sudden Decline in Active Membrane-Bound TGF-?? Impairs Both T Regulatory Cell Function and Protection against Autoimmune Diabetes, The Journal of Immunology, vol.173, issue.12, pp.7308-7316, 2004. ,
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Regulatory T Cells Is Mediated by Cell Surface???Bound Transforming Growth Factor ??, The Journal of Experimental Medicine, vol.157, issue.5, pp.629-644, 2001. ,
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Integration of TGF-??/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition, The EMBO Journal, vol.23, issue.5, pp.1155-1165, 2004. ,
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The Notch ligand Jagged-1 is able to induce maturation of monocyte-derived human dendritic cells Canonical and non-canonical Notch ligands, J Immunol Curr Top Dev Biol, vol.169, issue.92, pp.4273-4278, 2002. ,
DCs induce IL-12???independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS, The Journal of Experimental Medicine, vol.67, issue.7, pp.1525-1531, 2007. ,
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Regulation of T Cell Activation by Notch Ligand, DLL4, Promotes IL-17 Production and Rorc Activation, The Journal of Immunology, vol.182, issue.12, pp.7381-7388, 2009. ,
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Notch Increases T/NK Potential of Human Hematopoietic Progenitors and Inhibits B Cell Differentiation at a Pro-B Stage, Stem Cells, vol.452, issue.7, pp.1676-1685, 2009. ,
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Short exposure to Notch ligand Delta-4 is sufficient to induce T-cell differentiation program and to increase the T cell potential of primary human CD34+ cells, Experimental Hematology, vol.34, issue.12, pp.1720-1729, 2006. ,
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Inhibitors of ??-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21, Nature Immunology, vol.62, issue.7, pp.680-688, 2005. ,
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Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells, Cell, vol.117, issue.4, pp.515-526, 2004. ,
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were cultured for 5 days in wells coated with anti-CD3 (1µg/ml) in the presence of Notch ligands (5 µg/ml) or IgG control at different ratios. Percentages of inhibition were calculated from the raw data using the equations: 1-(mean cpm of co-culture wells divided by mean cpm of CD4 + CD25 -cells cultured alone) x 100 ,