Autocrine Growth Stimulation of the MCF 7 Breast Cancer Cells by the Estrogen-Regulated 52 K Protein*, Endocrinology, vol.118, issue.4, pp.1537-1545, 1986. ,
DOI : 10.1210/endo-118-4-1537
Increased secretion, altered processing, and glycosylation of pro-cathepsin D in human mammary cancer cells, Cancer Res, vol.49, pp.3904-3909, 1989. ,
Cathepsin-D in primary breast cancer: prognostic evaluation involving 2810 patients, British Journal of Cancer, vol.32, issue.2, pp.300-307, 1999. ,
DOI : 10.1038/sj.bjc.6690048
Relationship between cathepsin-D content and disease-free survival in node-negative breast cancer patients: a meta-analysis, British Journal of Cancer, vol.76, issue.5, 1997. ,
DOI : 10.1038/bjc.1997.442
Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis, Oncogene, vol.21, issue.38, 2002. ,
DOI : 10.1038/sj.onc.1205745
A mutated cathepsin-D devoid of its catalytic activity stimulates the growth of cancer cells, Oncogene, vol.20, issue.47, pp.6920-6929, 2001. ,
DOI : 10.1038/sj.onc.1204843
Catalytically inactive human cathepsin D triggers fibroblast invasive growth, The Journal of Cell Biology, vol.2, issue.3, pp.489-499, 2005. ,
DOI : 10.1038/sj.bjc.6690675
URL : https://hal.archives-ouvertes.fr/inserm-00153783
Pro-cathepsin D interacts with the extracellular domain of the beta chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth, J Cell Sci, vol.123, pp.3336-3346, 2010. ,
URL : https://hal.archives-ouvertes.fr/inserm-00518213
Thrombin Up-regulates Cathepsin D which Enhances Angiogenesis, Growth, and Metastasis, Cancer Research, vol.68, issue.12, pp.4666-4673, 2008. ,
DOI : 10.1158/0008-5472.CAN-07-6276
Down-regulation of cathepsin-D expression by antisense gene transfer inhibits tumor growth and experimental lung metastasis of human breast cancer cells, Oncogene, vol.21, issue.33, pp.5127-5134, 2002. ,
DOI : 10.1038/sj.onc.1205657
Lysosomal Enzyme Precursors in Human Fibroblasts. Activation of Cathepsin D Precursor in vitro and Activity of beta-Hexosaminidase A Precursor towards Ganglioside GM2, European Journal of Biochemistry, vol.78, issue.2, pp.317-321, 1982. ,
DOI : 10.1111/j.1432-1033.1982.tb06685.x
Causes and consequences of tumour acidity and implications for treatment, Molecular Medicine Today, vol.6, issue.1, 2000. ,
DOI : 10.1016/S1357-4310(99)01615-9
Contributions of Cell Metabolism and H+ Diffusion to the Acidic pH of Tumors, Neoplasia, vol.5, issue.2, pp.135-145, 2003. ,
DOI : 10.1016/S1476-5586(03)80005-2
Why Are Cancers Acidic? A Carrier-Mediated Diffusion Model for H+ Transport in the Interstitial Fluid, Novartis Found Symp, vol.240, pp.46-62, 2001. ,
DOI : 10.1002/0470868716.ch4
Cysteine cathepsins: multifunctional enzymes in cancer, Nature Reviews Cancer, vol.70, issue.10, pp.764-775, 2006. ,
DOI : 10.1038/nrc1949
Cystatins ??? Extra- and intracellular cysteine protease inhibitors: High-level secretion and uptake of cystatin C in human neuroblastoma cells, Biochimie, vol.92, issue.11, pp.1625-1634, 2010. ,
DOI : 10.1016/j.biochi.2010.08.011
Proteolytic networks in cancer, Trends in Cell Biology, vol.21, issue.4, pp.228-237, 2011. ,
DOI : 10.1016/j.tcb.2010.12.002
Degradomics: Systems biology of the protease web. Pleiotropic roles of MMPs in cancer, Cancer and Metastasis Reviews, vol.383, issue.1, pp.69-75, 2006. ,
DOI : 10.1007/s10555-006-7890-0
Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products, Nature Biotechnology, vol.461, issue.3, pp.281-288, 2010. ,
DOI : 10.1038/nbt.1611
Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates, Nature Protocols, vol.254, issue.10, pp.1578-1611, 2011. ,
DOI : 10.1021/pr050385q
TANDEM: matching proteins with tandem mass spectra, Bioinformatics, vol.20, issue.9, pp.1466-1467, 2004. ,
DOI : 10.1093/bioinformatics/bth092
URL : http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.335.8256
A Statistics-based Platform for Quantitative N-terminome Analysis and Identification of Protease Cleavage Products, Molecular & Cellular Proteomics, vol.9, issue.5, pp.912-927, 2010. ,
DOI : 10.1074/mcp.M000032-MCP201
Phospholipids activate cathepsin D, Biochemical and Biophysical Research Communications, vol.110, issue.3, pp.934-939, 1983. ,
DOI : 10.1016/0006-291X(83)91052-5
Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts, Biol Chem, vol.392, pp.961-971, 2011. ,
Inactivation of human cystatin C and kininogen by human cathepsin D, FEBS Letters, vol.271, issue.2, pp.211-215, 1991. ,
DOI : 10.1016/0014-5793(91)80295-E
Reduction of Experimental Human Fibrosarcoma Lung Metastasis in Mice by Adenovirus-Mediated Cystatin C Overexpression in the Host, Cancer Research, vol.65, issue.19, pp.8608-8612, 2005. ,
DOI : 10.1158/0008-5472.CAN-05-1572
Decreased metastatic spread in mice homozygous for a null allele of the cystatin C protease inhibitor gene, Molecular Pathology, vol.52, issue.6, pp.332-340, 1999. ,
DOI : 10.1136/mp.52.6.332
Cystatin C Is Downregulated in Prostate Cancer and Modulates Invasion of Prostate Cancer Cells via MAPK/Erk and Androgen Receptor Pathways, PLoS ONE, vol.4, issue.11, 2007. ,
DOI : 10.1371/journal.pone.0007953.t001
Cathepsin L Is Responsible for Processing and Activation of Proheparanase through Multiple Cleavages of a Linker Segment, Journal of Biological Chemistry, vol.283, issue.26, pp.18167-18176, 2008. ,
DOI : 10.1074/jbc.M801327200
Targeting proteases: successes, failures and future prospects, Nature Reviews Drug Discovery, vol.183, issue.9, pp.785-799, 2006. ,
DOI : 10.1038/nrd2092
Cysteine cathepsins (proteases)???On the main stage of cancer?, Cancer Cell, vol.5, issue.5, pp.409-410, 2004. ,
DOI : 10.1016/S1535-6108(04)00117-5
Proteomics Discovery of Metalloproteinase Substrates in the Cellular Context by iTRAQTM Labeling Reveals a Diverse MMP-2 Substrate Degradome, Molecular & Cellular Proteomics, vol.6, issue.4, pp.611-623, 2007. ,
DOI : 10.1074/mcp.M600341-MCP200
Cathepsin D is partly endocytosed by the LRP1 receptor and inhibits LRP1-regulated intramembrane proteolysis Procathepsin D interacts with prosaposin in cancer cells but its internalization is not mediated by LDL receptor-related protein, Oncogene Exp Cell Res, vol.35, issue.277, pp.210-219, 2002. ,
Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor 27, 2007. ,
The two sides of enzyme???substrate specificity: lessons from the aspartic proteinases, Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, vol.1477, issue.1-2, pp.231-240, 2000. ,
DOI : 10.1016/S0167-4838(99)00275-7
Cathepsin D inactivates cysteine proteinase inhibitors cystatins, Biochemical and Biophysical Research Communications, vol.154, issue.2, pp.765-772, 1988. ,
DOI : 10.1016/0006-291X(88)90206-9
Are cancer cells acidic?, British Journal of Cancer, vol.64, issue.3, pp.425-427, 1991. ,
DOI : 10.1038/bjc.1991.326
Coordinated involvement of cathepsins S, D and cystatin C in the commitment of hematopoietic stem cells to dendritic cells, Int J Biochem Cell Biol, vol.43, pp.775-783, 2011. ,
Activation of cathepsin B, secreted by a colorectal cancer cell line requires low pH and is mediated by cathepsin D, International Journal of Cancer, vol.50, issue.4, pp.547-554, 1996. ,
DOI : 10.1002/(SICI)1097-0215(19960807)67:4<547::AID-IJC14>3.0.CO;2-4
Voltage-gated Sodium Channel Activity Promotes Cysteine Cathepsin-dependent Invasiveness and Colony Growth of Human Cancer Cells, Journal of Biological Chemistry, vol.284, issue.13, pp.8680-8691, 2009. ,
DOI : 10.1074/jbc.M806891200