A. Alcami and U. H. Koszinowski, Viral mechanisms of immune evasion, Trends in Microbiology, vol.8, issue.9, pp.410-418, 2000.
DOI : 10.1016/S0966-842X(00)01830-8

N. Aptsiauri, T. Cabrera, A. Garcia-lora, M. A. Lopez-nevot, F. Ruiz-cabello et al., MHC Class I Antigens and Immune Surveillance in Transformed Cells, Int Rev Cytol, vol.256, pp.139-189, 2007.
DOI : 10.1016/S0074-7696(07)56005-5

R. Bartrons and J. Caro, Hypoxia, glucose metabolism and the Warburg???s effect, Journal of Bioenergetics and Biomembranes, vol.313, issue.3, pp.223-229, 2007.
DOI : 10.1007/s10863-007-9080-3

N. Bellance, P. Lestienne, and R. Rossignol, Mitochondria: from bioenergetics to the metabolic regulation of carcinogenesis, Front Biosci, vol.14, pp.4015-4034, 2009.

S. Bonnet, S. L. Archer, J. Allalunis-turner, A. Haromy, C. Beaulieu et al., A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth, Cancer Cell, vol.11, issue.1, pp.37-51, 2007.
DOI : 10.1016/j.ccr.2006.10.020

V. Bronte, P. Serafini, A. Mazzoni, D. M. Segal, and P. Zanovello, L-arginine metabolism in myeloid cells controls T-lymphocyte functions, Trends in Immunology, vol.24, issue.6, pp.302-306, 2003.
DOI : 10.1016/S1471-4906(03)00132-7

F. M. Burnet, The Concept of Immunological Surveillance, Prog Exp Tumor Res, vol.13, pp.1-27, 1970.
DOI : 10.1159/000386035

M. Campoli and S. Ferrone, HLA antigen changes in malignant cells: epigenetic mechanisms and biologic significance, Oncogene, vol.14, issue.45, pp.5869-5885, 2008.
DOI : 10.1128/MCB.20.7.2592-2603.2000

E. L. Carr, A. Kelman, G. S. Wu, R. Gopaul, E. Senkevitch et al., Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation, The Journal of Immunology, vol.185, issue.2, pp.1037-1044, 2010.
DOI : 10.4049/jimmunol.0903586

S. Charni, J. I. Aguilo, J. Garaude, G. De-bettignies, C. Jacquet et al., ERK5 Knockdown Generates Mouse Leukemia Cells with Low MHC Class I Levels That Activate NK Cells and Block Tumorigenesis, The Journal of Immunology, vol.182, issue.6, pp.3398-3405, 2009.
DOI : 10.4049/jimmunol.0803006

URL : https://hal.archives-ouvertes.fr/hal-00368654

S. Charni, G. De-bettignies, M. G. Rathore, J. I. Aguilo, P. J. Van-den-elsen et al., Oxidative Phosphorylation Induces De Novo Expression of the MHC Class I in Tumor Cells through the ERK5 Pathway, The Journal of Immunology, vol.185, issue.6, pp.3498-3503, 2010.
DOI : 10.4049/jimmunol.1001250

R. Chhabra, R. Dubey, and N. Saini, Cooperative and individualistic functions of the microRNAs in the miR-23a~27a~24-2 cluster and its implication in human diseases, Molecular Cancer, vol.9, issue.1, p.232, 2010.
DOI : 10.1186/1476-4598-9-232

B. C. Chiu, S. M. Gapstur, P. Greenland, R. Wang, and A. Dyer, Body Mass Index, Abnormal Glucose Metabolism, and Mortality from Hematopoietic Cancer, Cancer Epidemiology Biomarkers & Prevention, vol.15, issue.12, pp.2348-2354, 2006.
DOI : 10.1158/1055-9965.EPI-06-0007

N. P. Curthoys and M. Watford, Regulation of Glutaminase Activity and Glutamine Metabolism, Annual Review of Nutrition, vol.15, issue.1, pp.133-159, 1995.
DOI : 10.1146/annurev.nu.15.070195.001025

C. V. Dang, MYC, microRNAs and glutamine addiction in cancers, Cell Cycle, vol.8, issue.20, pp.3243-3245, 2009.
DOI : 10.4161/cc.8.20.9522

R. J. Deberardinis and T. Cheng, Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer, Oncogene, vol.124, issue.3, pp.313-324, 2010.
DOI : 10.1016/j.bbrc.2003.11.136

R. J. Deberardinis, A. Mancuso, E. Daikhin, I. Nissim, M. Yudkoff et al., Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis, Proceedings of the National Academy of Sciences, vol.104, issue.49, pp.19345-19350, 2007.
DOI : 10.1073/pnas.0709747104

K. Dietl, K. Renner, K. Dettmer, B. Timischl, K. Eberhart et al., Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes, The Journal of Immunology, vol.184, issue.3, pp.1200-1209, 2010.
DOI : 10.4049/jimmunol.0902584

A. S. Dighe, E. Richards, L. J. Old, and R. D. Schreiber, Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFN?? receptors, Immunity, vol.1, issue.6, pp.447-456, 1994.
DOI : 10.1016/1074-7613(94)90087-6

G. P. Dunn, A. T. Bruce, H. Ikeda, L. J. Old, and R. D. Schreiber, Cancer immunoediting: from immunosurveillance to tumor escape, Nature Immunology, vol.3, issue.11, pp.991-998, 2002.
DOI : 10.1038/ni1102-991

G. P. Dunn, C. M. Koebel, and R. D. Schreiber, Interferons, immunity and cancer immunoediting, Nature Reviews Immunology, vol.313, issue.11, pp.836-848, 2006.
DOI : 10.1038/nri1961

A. M. Engel, I. M. Svane, M. W. Madsen, M. Pedersen, and O. Werdelin, Molecular aberrations in the MHC class I-restricted pathway for antigen presentation in methylcholanthrene sarcomas from nude mice: discrepancies between MHC mRNA and surface protein, Clinical and Experimental Immunology, vol.109, issue.2, pp.323-331, 1997.
DOI : 10.1046/j.1365-2249.1997.4361335.x

A. M. Engel, I. M. Svane, S. Mouritsen, J. Rygaard, J. Clausen et al., Methylcholanthrene-induced sarcomas in nude mice have short induction times and relatively low levels of surface MHC class I expression, APMIS, vol.4, issue.7-8, pp.629-639, 1996.
DOI : 10.1111/j.1699-0463.1996.tb04923.x

A. M. Engel, I. M. Svane, J. Rygaard, and O. Werdelin, MCA Sarcomas Induced in scid Mice are More Immunogenic than MCA Sarcomas Induced in Congenic, Immunocompetent Mice, Scandinavian Journal of Immunology, vol.45, issue.4, pp.463-470, 1997.
DOI : 10.1046/j.1365-3083.1997.d01-419.x

K. Fischer, P. Hoffmann, S. Voelkl, N. Meidenbauer, J. Ammer et al., Inhibitory effect of tumor cell-derived lactic acid on human T cells, Blood, vol.109, issue.9, pp.3812-3819, 2007.
DOI : 10.1182/blood-2006-07-035972

D. F. Flavin, Non-Hodgkin's Lymphoma Reversal with Dichloroacetate, Journal of Oncology, vol.33, issue.3, 2010.
DOI : 10.1126/stke.3812007pe14

D. I. Gabrilovich and S. Nagaraj, Myeloid-derived suppressor cells as regulators of the immune system, Nature Reviews Immunology, vol.172, issue.3, pp.162-174, 2009.
DOI : 10.1038/nri2506

D. I. Gabrilovich, S. Ostrand-rosenberg, and V. Bronte, Coordinated regulation of myeloid cells by tumours, Nature Reviews Immunology, vol.205, issue.4, pp.253-268, 2012.
DOI : 10.1038/nri3175

P. Gao, I. Tchernyshyov, T. C. Chang, Y. S. Lee, K. Kita et al., c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism, Nature, vol.12, issue.7239, pp.762-765, 2009.
DOI : 10.1038/nature07823

J. Garaude, S. Cherni, S. Kaminski, E. Delepine, C. Chable-bessia et al., ERK5 Activates NF-??B in Leukemic T Cells and Is Essential for Their Growth In Vivo, The Journal of Immunology, vol.177, issue.11, pp.7607-7617, 2006.
DOI : 10.4049/jimmunol.177.11.7607

URL : https://hal.archives-ouvertes.fr/hal-00119762

J. Garaude, S. Kaminski, S. Charni, J. I. Aguilo, C. Jacquet et al., Impaired anti-leukemic immune response in PKC??-deficient mice, Molecular Immunology, vol.45, issue.12, pp.3463-3469, 2008.
DOI : 10.1016/j.molimm.2008.03.016

K. Goetze, S. Walenta, M. Ksiazkiewicz, L. A. Kunz-schughart, and W. Mueller-klieser, Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release, International Journal of Oncology, vol.39, pp.453-463, 2011.
DOI : 10.3892/ijo.2011.1055

V. Gogvadze, S. Orrenius, and B. Zhivotovsky, Mitochondria in cancer cells: what is so special about them?, Trends in Cell Biology, vol.18, issue.4, pp.165-173, 2008.
DOI : 10.1016/j.tcb.2008.01.006

E. Gottfried, L. A. Kunz-schughart, S. Ebner, W. Mueller-klieser, S. Hoves et al., Tumor-derived lactic acid modulates dendritic cell activation and antigen expression, Blood, vol.107, issue.5, pp.2013-2021, 2006.
DOI : 10.1182/blood-2005-05-1795

N. Guerra, Y. X. Tan, N. T. Joncker, A. Choy, F. Gallardo et al., NKG2D-Deficient Mice Are Defective in Tumor Surveillance in Models of Spontaneous Malignancy, Immunity, vol.28, issue.4, pp.571-580, 2008.
DOI : 10.1016/j.immuni.2008.02.016

D. L. Herber, W. Cao, Y. Nefedova, S. V. Novitskiy, S. Nagaraj et al., Lipid accumulation and dendritic cell dysfunction in cancer, Nature Medicine, vol.103, issue.8, pp.880-886, 2010.
DOI : 10.1038/nm.2172

D. Heshe, S. Hoogestraat, C. Brauckmann, U. Karst, J. Boos et al., Dichloroacetate metabolically targeted therapy defeats cytotoxicity of standard anticancer drugs, Cancer Chemotherapy and Pharmacology, vol.329, issue.3, pp.647-655, 2011.
DOI : 10.1007/s00280-010-1361-6

URL : https://hal.archives-ouvertes.fr/hal-00595954

F. Hirschhaeuser, U. G. Sattler, and W. Mueller-klieser, Lactate: A Metabolic Key Player in Cancer, Cancer Research, vol.71, issue.22, pp.6921-6925, 2011.
DOI : 10.1158/0008-5472.CAN-11-1457

S. H. Jee, H. Ohrr, J. W. Sull, J. E. Yun, M. Ji et al., Fasting Serum Glucose Level and Cancer Risk in Korean Men and Women, JAMA, vol.293, issue.2, pp.194-202, 2005.
DOI : 10.1001/jama.293.2.194

P. Jezek, L. Plecita-hlavata, K. Smolkova, and R. Rossignol, Distinctions and similarities of cell bioenergetics and the role of mitochondria in hypoxia, cancer, and embryonic development, The International Journal of Biochemistry & Cell Biology, vol.42, issue.5, pp.604-622, 2010.
DOI : 10.1016/j.biocel.2009.11.008

J. Julian, N. Dharmaraj, and D. D. Carson, MUC1 is a substrate for ??-secretase, Journal of Cellular Biochemistry, vol.78, issue.4, pp.802-815, 2009.
DOI : 10.1002/jcb.22292

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228317

D. H. Kaplan, V. Shankaran, A. S. Dighe, E. Stockert, M. Aguet et al., Demonstration of an interferon ??-dependent tumor surveillance system in immunocompetent mice, Proceedings of the National Academy of Sciences, vol.95, issue.13, pp.7556-7561, 1998.
DOI : 10.1073/pnas.95.13.7556

R. S. Kiss, M. R. Elliott, Z. Ma, Y. L. Marcel, and K. S. Ravichandran, Apoptotic Cells Induce a Phosphatidylserine-Dependent Homeostatic Response from Phagocytes, Current Biology, vol.16, issue.22, pp.2252-2258, 2006.
DOI : 10.1016/j.cub.2006.09.043

H. Lu, R. A. Forbes, and A. Verma, Hypoxia-inducible Factor 1 Activation by Aerobic Glycolysis Implicates the Warburg Effect in Carcinogenesis, Journal of Biological Chemistry, vol.277, issue.26, pp.23111-23115, 2002.
DOI : 10.1074/jbc.M202487200

T. Lu, R. Ramakrishnan, S. Altiok, J. I. Youn, P. Cheng et al., Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice, Journal of Clinical Investigation, vol.121, issue.10, pp.4015-4029, 2011.
DOI : 10.1172/JCI45862DS1

A. L. Mellor, D. Munn, P. Chandler, D. Keskin, T. Johnson et al., Tryptophan Catabolism and T Cell Responses, Adv Exp Med Biol, vol.527, pp.27-35, 2003.
DOI : 10.1007/978-1-4615-0135-0_3

R. D. Michalek, V. A. Gerriets, S. R. Jacobs, A. N. Macintyre, N. J. Maciver et al., Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets, The Journal of Immunology, vol.186, issue.6, pp.3299-3303, 2011.
DOI : 10.4049/jimmunol.1003613

E. D. Michelakis, G. Sutendra, P. Dromparis, L. Webster, A. Haromy et al., Metabolic Modulation of Glioblastoma with Dichloroacetate, Science Translational Medicine, vol.2, issue.31, pp.31-34, 2010.
DOI : 10.1126/scitranslmed.3000677

D. M. Moncada, S. J. Kammanadiminti, and K. Chadee, Mucin and Toll-like receptors in host defense against intestinal parasites, Trends in Parasitology, vol.19, issue.7, pp.305-311, 2003.
DOI : 10.1016/S1471-4922(03)00122-3

L. Mukundan, J. I. Odegaard, C. R. Morel, J. E. Heredia, J. W. Mwangi et al., PPAR-?? senses and orchestrates clearance of apoptotic cells to promote tolerance, Nature Medicine, vol.200, issue.11, pp.1266-1272, 2009.
DOI : 10.1038/nm.2048

N. , A. G. Bensinger, S. J. Hong, C. Beceiro, S. Bradley et al., Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR, Immunity, vol.31, pp.245-258, 2009.

S. Nagaraj, K. Gupta, V. Pisarev, L. Kinarsky, S. Sherman et al., Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer, Nature Medicine, vol.166, issue.7, pp.828-835, 2007.
DOI : 10.1038/nm1609

Y. Nakamura, H. Yasuoka, M. Tsujimoto, K. Yoshidome, M. Nakahara et al., Nitric Oxide in Breast Cancer: Induction of Vascular Endothelial Growth Factor-C and Correlation with Metastasis and Poor Prognosis, Clinical Cancer Research, vol.12, issue.4, pp.1201-1207, 2006.
DOI : 10.1158/1078-0432.CCR-05-1269

A. Pashov, B. Monzavi-karbassi, G. P. Raghava, and T. Kieber-emmons, Bridging Innate and Adaptive Antitumor Immunity Targeting Glycans, Journal of Biomedicine and Biotechnology, vol.159, issue.11, p.354068, 2010.
DOI : 10.1023/A:1012220902991

K. S. Ravichandran and U. Lorenz, Engulfment of apoptotic cells: signals for a good meal, Nature Reviews Immunology, vol.1585, issue.12, pp.964-974, 2007.
DOI : 10.1038/nri2214

L. J. Reitzer, B. M. Wice, and D. Kennell, Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells, J Biol Chem, vol.254, pp.2669-2676, 1979.

R. Rossignol, R. Gilkerson, R. Aggeler, K. Yamagata, S. J. Remington et al., Energy Substrate Modulates Mitochondrial Structure and Oxidative Capacity in Cancer Cells, Cancer Research, vol.64, issue.3, pp.985-993, 2004.
DOI : 10.1158/0008-5472.CAN-03-1101

V. Russo, Metabolism, LXR/LXR ligands, and tumor immune escape, Journal of Leukocyte Biology, vol.90, issue.4, pp.673-679, 2011.
DOI : 10.1189/jlb.0411198

I. Samudio, M. Fiegl, and M. Andreeff, Mitochondrial Uncoupling and the Warburg Effect: Molecular Basis for the Reprogramming of Cancer Cell Metabolism, Cancer Research, vol.69, issue.6, pp.2163-2166, 2009.
DOI : 10.1158/0008-5472.CAN-08-3722

J. A. Segura, M. A. Ruiz-bellido, M. Arenas, C. Lobo, J. Marquez et al., Ehrlich ascites tumor cells expressing anti???sense glutaminase mRNA lose their capacity to evade the mouse immune system, International Journal of Cancer, vol.91, issue.3, pp.379-384, 2001.
DOI : 10.1002/1097-0215(200002)9999:9999<::AID-IJC1046>3.3.CO;2-C

V. Shankaran, H. Ikeda, A. T. Bruce, J. M. White, P. E. Swanson et al., IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity, Nature, vol.410, issue.6832, pp.1107-1111, 2001.
DOI : 10.1038/35074122

D. R. Siemens, J. P. Heaton, M. A. Adams, J. Kawakami, and C. H. Graham, Phase II Study of Nitric Oxide Donor for Men With Increasing Prostate-specific Antigen Level After Surgery or Radiotherapy for Prostate Cancer, Urology, vol.74, issue.4, pp.878-883, 2009.
DOI : 10.1016/j.urology.2009.03.004

D. R. Siemens, N. Hu, A. K. Sheikhi, E. Chung, L. J. Frederiksen et al., Hypoxia Increases Tumor Cell Shedding of MHC Class I Chain-Related Molecule: Role of Nitric Oxide, Cancer Research, vol.68, issue.12, pp.4746-4753, 2008.
DOI : 10.1158/0008-5472.CAN-08-0054

K. Smolkova, L. Plecita-hlavata, N. Bellance, G. Benard, R. Rossignol et al., Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells, The International Journal of Biochemistry & Cell Biology, vol.43, issue.7, pp.950-968, 2011.
DOI : 10.1016/j.biocel.2010.05.003

L. H. Stockwin, S. X. Yu, S. Borgel, C. Hancock, T. L. Wolfe et al., Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC, International Journal of Cancer, vol.283, issue.11, pp.2510-2519, 2010.
DOI : 10.1002/ijc.25499

I. M. Svane, A. M. Engel, M. Nielsen, and O. Werdelin, Interferon-gamma-Induced MHC Class I Expression and Defects in Jak/Stat Signalling in Methylcholanthrene-Induced Sarcomas, Scandinavian Journal of Immunology, vol.46, issue.4, pp.379-387, 1997.
DOI : 10.1046/j.1365-3083.1997.d01-141.x

I. M. Svane, A. M. Engel, M. B. Nielsen, H. G. Ljunggren, J. Rygaard et al., Chemically induced sarcomas from nude mice are more immunogenic than similar sarcomas from congenic normal mice, European Journal of Immunology, vol.14, issue.8, pp.1844-1850, 1996.
DOI : 10.1002/eji.1830260827

I. M. Svane, A. M. Engel, A. R. Thomsen, and O. Werdelin, The Susceptibility to Cytotoxic T Lymphocyte Mediated Lysis of Chemically Induced Sarcomas from Immunodeficient and Normal Mice, Scandinavian Journal of Immunology, vol.45, issue.1, pp.28-35, 1997.
DOI : 10.1046/j.1365-3083.1997.d01-369.x

M. B. Torchinsky, J. Garaude, and J. M. Blander, Infection and apoptosis as a combined inflammatory trigger, Current Opinion in Immunology, vol.22, issue.1, pp.55-62, 2010.
DOI : 10.1016/j.coi.2010.01.003

M. D. Vesely, M. H. Kershaw, R. D. Schreiber, and M. J. Smyth, Natural Innate and Adaptive Immunity to Cancer, Annual Review of Immunology, vol.29, issue.1, pp.235-271, 2011.
DOI : 10.1146/annurev-immunol-031210-101324

P. Vigneri, F. Frasca, L. Sciacca, G. Pandini, and R. Vigneri, Diabetes and cancer, Endocrine Related Cancer, vol.16, issue.4, pp.1103-1123, 2009.
DOI : 10.1677/ERC-09-0087

E. Vivier, E. Tomasello, M. Baratin, T. Walzer, and S. Ugolini, Functions of natural killer cells, Nature Immunology, vol.178, issue.5, pp.503-510, 2008.
DOI : 10.1073/pnas.050588297

URL : https://hal.archives-ouvertes.fr/hal-00294184

O. Warburg, Metabolism of Tumors, 1930.

O. Warburg, On respiratory impairment in cancer cells, Science, vol.124, pp.269-270, 1956.

A. Weigert and B. Brune, Nitric oxide, apoptosis and macrophage polarization during tumor progression, Nitric Oxide, vol.19, issue.2, pp.95-102, 2008.
DOI : 10.1016/j.niox.2008.04.021

K. E. Wellen, G. Hatzivassiliou, U. M. Sachdeva, T. V. Bui, J. R. Cross et al., ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation, Science, vol.324, issue.5930, pp.1076-1080, 2009.
DOI : 10.1126/science.1164097

S. Whitehouse, R. H. Cooper, and P. J. Randle, Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids, Biochemical Journal, vol.141, issue.3, pp.761-774, 1974.
DOI : 10.1042/bj1410761

J. D. Wu, C. L. Atteridge, X. Wang, T. Seya, and S. R. Plymate, Obstructing Shedding of the Immunostimulatory MHC Class I Chain-Related Gene B Prevents Tumor Formation, Clinical Cancer Research, vol.15, issue.2, pp.632-640, 2009.
DOI : 10.1158/1078-0432.CCR-08-1305

A. Yaromina, V. Quennet, D. Zips, S. Meyer, G. Shakirin et al., Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts, International Journal of Radiation Biology, vol.81, issue.2, pp.972-980, 2009.
DOI : 10.3109/09553000903232868