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A distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects.

David Mutch 1, 2 Tune Pers 3, 4 Ramzi Temanni 1 Veronique Pelloux 1, 5 Adriana Marquez-Quiñones 6, 7 Claus Holst 4 Alfredo Martinez 8 Dimitris Babalis 9 Marleen van Baak 10 Teodora Handjieva-Darlenska 11 Celia Walker 12 Arne Astrup 13 Wim Saris 10 Dominique Langin 6, 7, 14 Nathalie Viguerie 6, 7 Jean-Daniel Zucker 1 Karine Clément 1, 5, *
* Corresponding author
1 CRC (UMR_S 872) - Centre de Recherche des Cordeliers
2 Department of Human Health and Nutritional Sciences
3 Center for Biological Sequence Analysis [Lyngby]
4 Institute of Preventive Medicine
5 Service Nutrition
6 Institut Fédératif de Recherche Bio-médicale
7 I2MC - Institut des Maladies Métaboliques et Cardiovasculaires
8 the Department of Physiology and Nutrition
9 Department of Internal Medicine
10 NUTRIM - Nutrition Research Centre
11 National Multiprofile Transport Hospital
12 Human Nutrition Research
13 Department of Human Nutrition
14 Laboratoire de Biochimie [Purpan]
Abstract : BACKGROUND: Weight loss has been shown to reduce risk factors associated with cardiovascular disease and diabetes; however, successful maintenance of weight loss continues to pose a challenge. OBJECTIVE: The present study was designed to assess whether changes in subcutaneous adipose tissue (scAT) gene expression during a low-calorie diet (LCD) could be used to differentiate and predict subjects who experience successful short-term weight maintenance from subjects who experience weight regain. DESIGN: Forty white women followed a dietary protocol consisting of an 8-wk LCD phase followed by a 6-mo weight-maintenance phase. Participants were classified as weight maintainers (WMs; 0-10% weight regain) and weight regainers (WRs; 50-100% weight regain) by considering changes in body weight during the 2 phases. Anthropometric measurements, bioclinical variables, and scAT gene expression were studied in all individuals before and after the LCD. Energy intake was estimated by using 3-d dietary records. RESULTS: No differences in body weight and fasting insulin were observed between WMs and WRs at baseline or after the LCD period. The LCD resulted in significant decreases in body weight and in several plasma variables in both groups. WMs experienced a significant reduction in insulin secretion in response to an oral-glucose-tolerance test after the LCD; in contrast, no changes in insulin secretion were observed in WRs after the LCD. An ANOVA of scAT gene expression showed that genes regulating fatty acid metabolism, citric acid cycle, oxidative phosphorylation, and apoptosis were regulated differently by the LCD in WM and WR subjects. CONCLUSION: This study suggests that LCD-induced changes in insulin secretion and scAT gene expression may have the potential to predict successful short-term weight maintenance. This trial was registered at clinicaltrials.gov as NCT00390637.
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https://www.hal.inserm.fr/inserm-00726571
Contributor : Marie Francoise Simon Connect in order to contact the contributor
Submitted on : Thursday, August 30, 2012 - 4:05:56 PM
Last modification on : Tuesday, October 19, 2021 - 11:09:29 PM

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INSERM | UPMC | CORDELIERS | UNIV-PARIS13 | UNIV-PARIS5 | USPC | CNRS | SORBONNE-UNIVERSITE | UNIV-TLSE3 | SU-SCIENCES | SORBONNE-PARIS-NORD | UNIV-PARIS | IRD | SU-TI

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David Mutch, Tune Pers, Ramzi Temanni, Veronique Pelloux, Adriana Marquez-Quiñones, et al.. A distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects.. American Journal of Clinical Nutrition, American Society for Nutrition, 2011, 94 (6), pp.1399-409. ⟨10.3945/ajcn.110.006858⟩. ⟨inserm-00726571⟩

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