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Adipose Tissue Secretion and Expression of Adipocyte-Produced and Stromavascular Fraction-Produced Adipokines Vary during Multiple Phases of Weight-Reducing Dietary Intervention in Obese Women.

Abstract : Context: Obesity is associated with altered plasma levels of adipokines involved in the development of insulin resistance and obesity-related metabolic disturbances. Objective: The aim was to investigate diet-induced changes in adipokine production in sc abdominal adipose tissue (SAT) during a 6-month, multiphase, weight-reducing dietary intervention. Design, Setting, Participants, and Interventions: Forty-eight obese women followed a dietary intervention consisting of a very low-calorie diet (VLCD) (1 month), followed by a weight-stabilization (WS) period, which consisted of a low-calorie diet (2 months), and a weight-maintenance diet (3 months). Main Outcome Measures: Before and at the end of the VLCD and WS, samples of plasma and SAT were obtained. In a subgroup of 26 women, secretion of adipokines was determined in SAT explants, and in a subgroup of 22 women, SAT mRNA expression was measured. Results: Body weight decreased and insulin sensitivity increased during the intervention. Plasma levels, SAT mRNA expression, and secretion rates of adipocyte-produced adipokines (leptin, serum amyloid A, and haptoglobin) decreased during the VLCD and increased during the WS period. Adipokines produced mainly from stroma-vascular cells (IL-6, IL-8, IL-10, IL-1Ra, TNFα, plasminogen activator inhibitor-1, and monocyte chemoattractant protein-1) increased or remained unchanged during VLCD and decreased to levels equal to or lower than prediet levels during the WS period. The diet-induced changes in homeostasis model assessment of insulin resistance correlated with changes in leptin plasma levels during VLCD, WS, and the entire dietary intervention period. Conclusions: Diet-induced regulation of adipokine production in SAT differs according to their cellular origin (adipocytes vs. stroma-vascular cells) and diet phase (VLCD vs. WS). Insulin-sensitivity changes were associated only with those of plasma leptin.
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https://www.hal.inserm.fr/inserm-00726516
Contributor : Marie Francoise Simon <>
Submitted on : Thursday, August 30, 2012 - 2:54:36 PM
Last modification on : Friday, January 10, 2020 - 9:09:54 PM

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Michaela Siklova-Vitkova, Eva Klimcakova, Jan Polak, Zuzana Kovacova, Michaela Tencerova, et al.. Adipose Tissue Secretion and Expression of Adipocyte-Produced and Stromavascular Fraction-Produced Adipokines Vary during Multiple Phases of Weight-Reducing Dietary Intervention in Obese Women.. Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2012, 97 (7), pp.E1176-81. ⟨10.1210/jc.2011-2380⟩. ⟨inserm-00726516⟩

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