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Journal Articles Science Year : 2012

Host-gut microbiota metabolic interactions.

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Abstract

The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and life-style. The gut microbiota is involved in the regulation of multiple host metabolic pathways, giving rise to interactive host-microbiota metabolic, signaling, and immune-inflammatory axes that physiologically connect the gut, liver, muscle, and brain. A deeper understanding of these axes is a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health.
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Dates and versions

inserm-00726159 , version 1 (29-08-2012)

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Jeremy K. Nicholson, Elaine Holmes, James Kinross, Remy Burcelin, Glenn Gibson, et al.. Host-gut microbiota metabolic interactions.. Science, 2012, 336 (6086), pp.1262-7. ⟨10.1126/science.1223813⟩. ⟨inserm-00726159⟩
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