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Targeting tetraspanins in cancer.

Abstract : Introduction: Tetraspanins are a family of small proteins that cross the membrane four times and form complexes by interacting between themselves and with a variety of transmembrane and cytosolic proteins, building a network of interactions referred to as tetraspanin web or tetraspanin enriched microdomains (TEMs). These domains provide a signaling platform involved in many important cellular functions and malignant processes. Areas covered: The authors describe the methods and the rationale for targeting tetraspanins in the therapy of cancer in this review. Expert opinion: Targeting tetraspanins in cancer may be a promising therapy due to the importance of tetraspanins in several steps of tumor formation, communication with the environment, dissemination, and metastasis.
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Submitted on : Thursday, August 23, 2012 - 12:59:28 PM
Last modification on : Monday, January 19, 2015 - 11:49:49 AM
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Monica Sala-Valdes, Naouel Ailane, Céline Greco, Eric Rubinstein, Claude Boucheix. Targeting tetraspanins in cancer.. Expert Opinion on Therapeutic Targets, Taylor & Francis, 2012, 32 (1), epub ahead of print. ⟨10.1517/14728222.2012.712688⟩. ⟨inserm-00724944⟩



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