Skip to Main content Skip to Navigation
Journal articles

Myeloid malignancies: mutations, models and management.

Abstract : ABSTRACT: Myeloid malignant diseases comprise chronic (including myelodysplastic syndromes, myeloproliferative neoplasms and chronic myelomonocytic leukemia) and acute (acute myeloid leukemia) stages. They are clonal diseases arising in hematopoietic stem or progenitor cells. Mutations responsible for these diseases occur in several genes whose encoded proteins belong principally to five classes: signaling pathways proteins (e.g. CBL, FLT3, JAK2, RAS), transcription factors (e.g. CEBPA, ETV6, RUNX1), epigenetic regulators (e.g. ASXL1, DNMT3A, EZH2, IDH1, IDH2, SUZ12, TET2, UTX), tumor suppressors (e.g. TP53), and components of the spliceosome (e.g. SF3B1, SRSF2). Large-scale sequencing efforts will soon lead to the establishment of a comprehensive repertoire of these mutations, allowing for a better definition and classification of myeloid malignancies, the identification of new prognostic markers and therapeutic targets, and the development of novel therapies. Given the importance of epigenetic deregulation in myeloid diseases, the use of drugs targeting epigenetic regulators appears as a most promising therapeutic approach.
Document type :
Journal articles
Complete list of metadatas

Cited literature [135 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00723845
Contributor : Ed. Bmc <>
Submitted on : Tuesday, August 14, 2012 - 5:03:00 PM
Last modification on : Thursday, December 20, 2018 - 11:19:08 AM
Long-term archiving on: : Thursday, November 15, 2012 - 2:30:29 AM

Files

Identifiers

Collections

Citation

Anne Murati, Mandy Brecqueville, Raynier Devillier, Marie-Joelle Mozziconacci, Véronique Gelsi-Boyer, et al.. Myeloid malignancies: mutations, models and management.. BMC Cancer, BioMed Central, 2012, 12 (1), pp.304. ⟨10.1186/1471-2407-12-304⟩. ⟨inserm-00723845⟩

Share

Metrics

Record views

247

Files downloads

558