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Journal articles
DCC constrains tumour progression via its dependence receptor activity.
Abstract : The role of deleted in colorectal carcinoma (DCC) as a tumour suppressor has been a matter of debate for the past 15 years. DCC gene expression is lost or markedly reduced in the majority of advanced colorectal cancers and, by functioning as a dependence receptor, DCC has been shown to induce apoptosis unless engaged by its ligand, netrin-1 (ref. 2). However, so far no animal model has supported the view that the DCC loss-of-function is causally implicated as predisposing to aggressive cancer development. To investigate the role of DCC-induced apoptosis in the control of tumour progression, here we created a mouse model in which the pro-apoptotic activity of DCC is genetically silenced. Although the loss of DCC-induced apoptosis in this mouse model is not associated with a major disorganization of the intestines, it leads to spontaneous intestinal neoplasia at a relatively low frequency. Loss of DCC-induced apoptosis is also associated with an increase in the number and aggressiveness of intestinal tumours in a predisposing APC mutant context, resulting in the development of highly invasive adenocarcinomas. These results demonstrate that DCC functions as a tumour suppressor via its ability to trigger tumour cell apoptosis.
https://www.hal.inserm.fr/inserm-00721045
Contributor : Alain Puisieux Connect in order to contact the contributor
Submitted on : Thursday, July 26, 2012 - 2:32:55 PM
Last modification on : Tuesday, October 19, 2021 - 11:07:40 PM
Contributor : Alain Puisieux Connect in order to contact the contributor
Submitted on : Thursday, July 26, 2012 - 2:32:55 PM
Last modification on : Tuesday, October 19, 2021 - 11:07:40 PM
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