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Correlation between Fecal Concentrations of Ciprofloxacin and Fecal Counts of Resistant Enterobacteriaceae in Piglets Treated with Ciprofloxacin: toward New Means To Control the Spread of Resistance?: CIPROFLOXACIN LEVELS AND RESISTANT BACTERIA IN FECES

Abstract : We assessed in a piglet model the relationship between fecal ciprofloxacin concentrations and ciprofloxacin-resistant Enterobacteriaceae counts. Twenty-nine piglets were orally treated with placebo or with 1.5 or 15 mg ciprofloxacin/kg of body weight/day from day 1 (D1) to D5. Areas under the curve (AUC) of concentrations increased sharply with dose and correlated positively with AUC of resistant bacteria log counts between D1 and D9. Removing residual colonic quinolones could help to control the emergence of resistance in fecal flora.
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https://www.hal.inserm.fr/inserm-00719159
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Submitted on : Thursday, July 19, 2012 - 10:57:01 AM
Last modification on : Wednesday, August 19, 2020 - 11:16:55 AM
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Thu Thuy Nguyen, Elisabeth Chachaty, Clarisse Huy, Carole Cambier, Jean de Gunzburg, et al.. Correlation between Fecal Concentrations of Ciprofloxacin and Fecal Counts of Resistant Enterobacteriaceae in Piglets Treated with Ciprofloxacin: toward New Means To Control the Spread of Resistance?: CIPROFLOXACIN LEVELS AND RESISTANT BACTERIA IN FECES. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2012, 56 (9), pp.4973-5. ⟨10.1128/AAC.06402-11⟩. ⟨inserm-00719159⟩

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