K. Luger, A. W. Mader, R. K. Richmond, D. F. Sargent, R. et al., Crystal structure of the nucleosome core particle at 2.8 A resolution, Nature, vol.389, pp.251-260, 1997.

K. Van-holde and J. Zlatanova, Chromatin fiber structure: Where is the problem now?, Seminars in Cell & Developmental Biology, vol.18, issue.5, pp.651-658, 2007.
DOI : 10.1016/j.semcdb.2007.08.005

C. L. Woodcock and R. P. Ghosh, Chromatin Higher-order Structure and Dynamics, Cold Spring Harbor Perspectives in Biology, vol.2, issue.5, p.596, 2010.
DOI : 10.1101/cshperspect.a000596

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857170

P. R. Cook, The Organization of Replication and Transcription, Science, vol.284, issue.5421, pp.1790-1795, 1999.
DOI : 10.1126/science.284.5421.1790

A. Go¨ndo¨rgo¨ndo¨go¨ndo¨r and R. Ohlsson, Chromosome crosstalk in three dimensions, Nature, vol.5, issue.7261, pp.212-217, 2009.
DOI : 10.1038/nature08453

D. Gerlich and J. Ellenberg, 4D imaging to assay complex dynamics in live specimens, Nat. Cell. Biol, pp.14-19, 2003.

T. Cremer, M. Cremer, S. Dietzel, S. Muller, I. Solovei et al., Chromosome territories ??? a functional nuclear landscape, Current Opinion in Cell Biology, vol.18, issue.3, pp.307-316, 2006.
DOI : 10.1016/j.ceb.2006.04.007

E. Lieberman-aiden, N. L. Van-berkum, L. Williams, M. Imakaev, T. Ragoczy et al., Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome, Science, vol.326, issue.5950, pp.289-293, 2009.
DOI : 10.1126/science.1181369

A. Bancaud, S. Huet, N. Daigle, J. Beaudouin, J. Mozziconacci et al., Molecular crowding affects diffusion and binding of nuclear proteins in heterochromatin and reveals the fractal organization of chromatin, The EMBO Journal, vol.295, issue.24, pp.3785-3798, 2009.
DOI : 10.1146/ANNUREV.BIOPHYS.22.1.27

A. L. Goldberger, Non-linear dynamics for clinicians: chaos theory, fractals, and complexity at the bedside, The Lancet, vol.347, issue.9011, pp.1312-1314, 1996.
DOI : 10.1016/S0140-6736(96)90948-4

S. Havlin, S. V. Buldyrev, A. L. Goldberger, R. N. Mantegna, S. M. Ossadnik et al., Fractals in biology and medicine, Chaos, Solitons & Fractals, vol.6, pp.171-201, 1995.
DOI : 10.1016/0960-0779(95)80025-C

O. Heymans, J. Fissette, P. Vico, S. Blacher, D. Masset et al., Is fractal geometry useful in medicine and biomedical sciences?, Medical Hypotheses, vol.54, issue.3, pp.360-366, 2000.
DOI : 10.1054/mehy.1999.0848

S. V. Buldyrev, A. L. Goldberger, S. Havlin, C. Peng, M. Simons et al., Long-range fractal correlations in DNA, Physical Review Letters, vol.71, issue.11, p.1776, 1993.
DOI : 10.1103/PhysRevLett.71.1776

P. Cristea and G. Popescu, 1st SouthEast European Symposium on Interdisciplinary Approachees in Fractal Analysis, pp.131-134, 2003.

S. Garte, Fractal properties of the human genome, Journal of Theoretical Biology, vol.230, issue.2, pp.251-260, 2004.
DOI : 10.1016/j.jtbi.2004.05.015

S. Nicolay, E. B. Brodie-of-brodie, M. Touchon, B. Audit, Y. Aubenton-carafa et al., Bifractality of human DNA strand-asymmetry profiles results from transcription, Physical Review E, vol.75, issue.3, p.32902, 2007.
DOI : 10.1103/PhysRevE.75.032902

URL : https://hal.archives-ouvertes.fr/ensl-00198448

R. F. Voss, noise in DNA base sequences, Physical Review Letters, vol.68, issue.25, pp.3805-3808, 1992.
DOI : 10.1103/PhysRevLett.68.3805

A. S. Borovik, A. Grosberg, and M. D. Frank-kamenetskii, Fractality of DNA Texts, Journal of Biomolecular Structure and Dynamics, vol.35, issue.1, pp.655-669, 1994.
DOI : 10.1142/S0218348X93000083

A. Arneodo, C. Vaillant, B. Audit, F. Argoul, Y. Aubenton-carafa et al., Multi-scale coding of genomic information: From DNA sequence to genome structure and function, Physics Reports, vol.498, issue.2-3, pp.45-188, 2011.
DOI : 10.1016/j.physrep.2010.10.001

URL : https://hal.archives-ouvertes.fr/ensl-00572973

A. Y. Grosberg, Y. Rabin, S. Havlin, and A. Neer, Crumpled Globule Model of the Three-Dimensional Structure of DNA, Europhysics Letters (EPL), vol.23, issue.5, pp.373-378, 1993.
DOI : 10.1209/0295-5075/23/5/012

A. Y. Grosberg, S. K. Nechaev, and E. I. Shakhnovich, The role of topological constraints in the kinetics of collapse of macromolecules, Journal de Physique, vol.49, issue.12, pp.2095-2100, 1988.
DOI : 10.1051/jphys:0198800490120209500

URL : https://hal.archives-ouvertes.fr/jpa-00210891

T. A. Witten, Polymer solutions: A geometric introduction, Reviews of Modern Physics, vol.70, issue.4, pp.1531-1544, 1998.
DOI : 10.1103/RevModPhys.70.1531

J. G. Mcnally and D. Mazza, Fractal geometry in the nucleus, The EMBO Journal, vol.29, issue.1, pp.2-3, 2010.
DOI : 10.1038/emboj.2009.340

L. A. Mirny, The fractal globule as a model of chromatin architecture in the cell, Chromosome Research, vol.130, issue.Pt 19, pp.37-51, 2011.
DOI : 10.1007/s10577-010-9177-0

A. Sanyal, D. Bau, M. A. Marti-renom, and J. Dekker, Chromatin globules: a common motif of higher order chromosome structure?, Current Opinion in Cell Biology, vol.23, issue.3, pp.325-331, 2011.
DOI : 10.1016/j.ceb.2011.03.009

B. Bohrmann, M. Haider, and E. Kellenberger, Concentration evaluation of chromatin in unstained resin-embedded sections by means of low-dose ratio-contrast imaging in STEM, Ultramicroscopy, vol.49, issue.1-4, pp.235-251, 1993.
DOI : 10.1016/0304-3991(93)90230-U

D. Cassi and S. Regina, Spectral dimension of branched structures: Universality in geometrical disorder, Physical Review Letters, vol.70, issue.11, pp.1647-1649, 1993.
DOI : 10.1103/PhysRevLett.70.1647

J. Beaudouin, F. Mora-bermudez, T. Klee, N. Daigle, and J. Ellenberg, Dissecting the Contribution of Diffusion and Interactions to the Mobility of Nuclear Proteins, Biophysical Journal, vol.90, issue.6, pp.1878-1894, 2006.
DOI : 10.1529/biophysj.105.071241

M. J. Saxton, Anomalous diffusion due to obstacles: a Monte Carlo study, Biophysical Journal, vol.66, issue.2, pp.394-401, 1994.
DOI : 10.1016/S0006-3495(94)80789-1

S. Ben-avraham and S. Havlin, Diffusion and Reactions in Fractals and Disordered Systems, 2000.
DOI : 10.1017/CBO9780511605826

A. J. Einstein, H. Wu, M. Sanchez, and J. Gil, Fractal characterization of chromatin appearance for diagnosis in breast cytology, The Journal of Pathology, vol.15, issue.4, pp.366-381, 1998.
DOI : 10.1002/(SICI)1096-9896(199808)185:4<366::AID-PATH122>3.0.CO;2-C

D. V. Lebedev, M. V. Filatov, A. I. Kuklin, A. K. Islamov, E. Ketzinger et al., Fractal nature of chromatin organization in interphase chicken erythrocyte nuclei: DNA structure exhibits biphasic fractal properties, FEBS Letters, vol.72, issue.6, pp.1465-1468, 2005.
DOI : 10.1016/j.febslet.2005.01.052

H. Yokota, G. Van-den-engh, J. E. Hearst, R. K. Sachs, and B. J. Trask, Evidence for the organization of chromatin in megabase pair-sized loops arranged along a random walk path in the human G0/G1 interphase nucleus, The Journal of Cell Biology, vol.130, issue.6, pp.1239-1249, 1995.
DOI : 10.1083/jcb.130.6.1239

R. K. Sachs, G. Van-den-engh, B. Trask, H. Yokota, and J. E. Hearst, A random-walk/giant-loop model for interphase chromosomes., Proc. Natl Acad. Sci. USA, pp.2710-2714, 1995.
DOI : 10.1073/pnas.92.7.2710

K. F. To´thto´th, T. A. Knoch, M. Wachsmuth, M. Frank-sto¨hrsto¨hr, M. Sto¨hrsto¨hr et al., Trichostatin A-induced histone acetylation causes decondensation of interphase chromatin, J. Cell. Sci, vol.15, pp.4277-4287, 2004.

A. Huisman, L. S. Ploeger, H. F. Dullens, N. Poulin, W. E. Grizzle et al., Development of 3D chromatin texture analysis using confocal laser scanning microscopy, Cell Oncol, vol.27, pp.335-345, 2005.

R. C. Ferreira, P. S. De-matos, R. L. Adam, N. J. Leite, and K. Metze, Application of the Minkowski-Bouligand fractal dimension for the differential diagnosis of thyroid follicular neoplasias, Cell Oncol, vol.28, pp.331-333, 2006.

M. R. Mello, K. Metze, R. L. Adam, F. G. Pereira, M. G. Magalhaes et al., Phenotypic subtypes of acute lymphoblastic leukemia associated with different nuclear chromatin texture, Anal. Quant. Cytol. Histol, vol.30, pp.92-98, 2008.

K. Metze, R. C. Ferreira, R. L. Adam, N. J. Leite, L. S. Ward et al., Chromatin Texture is Size Dependent in Follicular Adenomas But Not in Hyperplastic Nodules of the Thyroid, World Journal of Surgery, vol.28, issue.12, pp.2744-2746, 2008.
DOI : 10.1007/s00268-008-9736-0

C. Castelli and G. A. Rosa, Ultrastructural Complexity of Nuclear Components During Early Apoptotic Phases in Breast Cancer Cells, Analytical Cellular Pathology, vol.23, issue.1, pp.1-9, 2001.
DOI : 10.1155/2001/828309

A. P. Pentland, Fractal-Based Description of Natural Scenes, IEEE Transactions on Pattern Analysis and Machine Intelligence, vol.6, issue.6, pp.661-674, 1984.
DOI : 10.1109/TPAMI.1984.4767591

D. V. Lebedev, M. V. Filatov, A. I. Kuklin, A. K. Islamov, J. Stellbrink et al., Structural hierarchy of chromatin in chicken erythrocyte nuclei based on small-angle neutron scattering: Fractal nature of the large-scale chromatin organization, Crystallography Reports, vol.53, issue.1, pp.110-115, 2008.
DOI : 10.1134/S1063774508010136

J. Dekker, The three 'C' s of chromosome conformation capture: controls, controls, controls, Nature Methods, vol.306, issue.1, pp.17-21, 2006.
DOI : 10.1038/nmeth823

M. Weiss, M. Elsner, F. Kartberg, and T. Nilsson, Anomalous Subdiffusion Is a Measure for Cytoplasmic Crowding in Living Cells, Biophysical Journal, vol.87, issue.5, pp.3518-3524, 2004.
DOI : 10.1529/biophysj.104.044263

M. J. Saxton, Lateral diffusion in an archipelago. Dependence on tracer size, Biophysical Journal, vol.64, issue.4, pp.1053-1062, 1993.
DOI : 10.1016/S0006-3495(93)81471-1

G. Guigas and M. Weiss, Sampling the Cell with Anomalous Diffusion???The Discovery of Slowness, Biophysical Journal, vol.94, issue.1, pp.90-94, 2008.
DOI : 10.1529/biophysj.107.117044

O. Seksek, J. Biwersi, and A. S. Verkman, Translational Diffusion of Macromolecule-sized Solutes in Cytoplasm and Nucleus, The Journal of Cell Biology, vol.7, issue.1, pp.131-142, 1997.
DOI : 10.1016/0968-0004(94)90019-1

C. Pack, K. Saito, M. Tamura, and M. Kinjo, Microenvironment and Effect of Energy Depletion in the Nucleus Analyzed by Mobility of Multiple Oligomeric EGFPs, Biophysical Journal, vol.91, issue.10, pp.3921-3936, 2006.
DOI : 10.1529/biophysj.105.079467

D. Grunwald, R. M. Martin, V. Buschmann, D. P. Bazett-jones, H. Leonhardt et al., Probing Intranuclear Environments at the Single-Molecule Level, Biophysical Journal, vol.94, issue.7, pp.2847-2858, 2008.
DOI : 10.1529/biophysj.107.115014

M. Wachsmuth, W. Waldeck, and J. Langowski, Anomalous diffusion of fluorescent probes inside living cell nuclei investigated by spatially-resolved fluorescence correlation spectroscopy, Journal of Molecular Biology, vol.298, issue.4, pp.677-689, 2000.
DOI : 10.1006/jmbi.2000.3692

J. Crawford and N. Matsui, Heterogeneity of the pore and solid volume of soil: distinguishing a fractal space from its non-fractal complement, Geoderma, vol.73, issue.3-4, pp.183-195, 1996.
DOI : 10.1016/0016-7061(96)00045-6

A. Dathe and M. Thullner, The relationship between fractal properties of solid matrix and pore space in porous media, Geoderma, vol.129, issue.3-4, pp.279-290, 2005.
DOI : 10.1016/j.geoderma.2005.01.003

S. R. Mc-guffee and A. H. Elcock, Diffusion, Crowding & Protein Stability in a Dynamic Molecular Model of the Bacterial Cytoplasm, PLoS Computational Biology, vol.14, issue.3, p.1000694, 2010.
DOI : 10.1371/journal.pcbi.1000694.s015

D. Avnir, O. Biham, D. Lidar, and O. Malcai, Is the geometry of nature fractal? Science, pp.39-40, 1998.

D. W. Schaefer and K. D. Keefer, Structure of Random Porous Materials: Silica Aerogel, Physical Review Letters, vol.56, issue.20, p.2199, 1986.
DOI : 10.1103/PhysRevLett.56.2199

D. W. Schaeffer and K. D. Keefer, Fractal Geometry of Silica Condensation Polymers, Physical Review Letters, vol.53, issue.14, pp.1383-1386, 1984.
DOI : 10.1103/PhysRevLett.53.1383

S. Condamin, V. Tejedor, R. Voituriez, O. Be´nichoube´nichou, and J. Klafter, Probing microscopic origins of confined subdiffusion by first-passage observables, Proc. Natl Acad. Sci. USA, pp.5675-5680, 2008.
DOI : 10.1073/pnas.0712158105

O. Be´nichoube´nichou, C. Chevalie, J. Klafter, B. Meyer, and R. Voituriez, Geometry-controlled kinetics, Nature Chemistry, vol.2, issue.6, pp.472-477, 2010.
DOI : 10.1134/S1063774508010136

S. Condamin, O. Be´nichoube´nichou, V. Tejedor, R. Voituriez, and J. Klafter, First-passage times in complex scale-invariant media, Nature, vol.2, issue.7166, pp.77-80, 2007.
DOI : 10.1038/nature06201

S. Rea, F. Eisenhaber, D. O-'carroll, B. D. Strahl, Z. W. Sun et al., Regulation of chromatin structure by site-specific histone H3 methyltransferases, Nature, vol.406, pp.593-599, 2000.

P. Trojer and D. Reinberg, Facultative Heterochromatin: Is There a Distinctive Molecular Signature?, Molecular Cell, vol.28, issue.1, pp.1-13, 2007.
DOI : 10.1016/j.molcel.2007.09.011

G. Spinelli, Heterochromatin and complexity: a theoretical approach, Nonlinear Dynamics, Psychology, and Life Sciences, vol.7, issue.4, pp.329-361, 2003.
DOI : 10.1023/A:1025980007520

B. Meyer, O. Be´nichoube´nichou, Y. Kafri, and R. Voituriez, Geometry-Induced Bursting Dynamics in Gene Expression, Biophysical Journal, vol.102, issue.9, pp.2186-2191, 2012.
DOI : 10.1016/j.bpj.2012.03.060

I. Solovei, A. Cavallo, L. Schermelleh, F. Jaunin, C. Scasselati et al., Spatial Preservation of Nuclear Chromatin Architecture during Three-Dimensional Fluorescence in Situ Hybridization (3D-FISH), Experimental Cell Research, vol.276, issue.1, p.3, 2002.
DOI : 10.1006/excr.2002.5513

M. Emanuel, N. H. Rajda, A. Henriksson, and H. Schiessel, The physics behind the larger scale organization of DNA in eukaryotes, Physical Biology, vol.6, issue.2, p.25008, 2009.
DOI : 10.1088/1478-3975/6/2/025008

M. Bohn and D. W. Heermann, Conformational properties of compact polymers, The Journal of Chemical Physics, vol.130, issue.17, 2009.
DOI : 10.1063/1.3126651

M. Bohn and D. W. Heermann, Diffusion-Driven Looping Provides a Consistent Framework for Chromatin Organization, PLoS ONE, vol.61, issue.8, 2010.
DOI : 10.1371/journal.pone.0012218.s006

A. Rosa and R. Everaers, Structure and Dynamics of Interphase Chromosomes, PLoS Computational Biology, vol.25, issue.8, 2008.
DOI : 10.1371/journal.pcbi.1000153.t001

K. Metze, R. L. Adam, J. R. Vido, and I. G. Lorand-metze, The influence of staining characteristics on nuclear texture features in cytology, Anal. Quant. Cytol. Histol, vol.31, pp.241-246, 2009.

S. A. Latt and J. C. Wohlleb, Optical studies of the interaction of 33258 Hoechst with DNA, chromatin, and metaphase chromosomes, Chromosoma, vol.1, issue.4, pp.297-316, 1975.
DOI : 10.1007/BF00364015

R. M. Martin, H. Leonhardt, and M. C. Cardoso, DNA labeling in living cells, Cytometry Part A, vol.275, issue.1, pp.45-52, 2005.
DOI : 10.1002/cyto.a.20172

D. Zink, N. Sadoni, and E. Stelzer, Visualizing chromatin and chromosomes in living cells, Methods, vol.29, issue.1, pp.42-50, 2003.
DOI : 10.1016/S1046-2023(02)00289-X

K. Monier, J. C. Armas, S. Etteldorf, P. Ghazal, and K. F. Sullivan, Annexation of the interchromosomal space during viral infection, Nat. Cell. Biol, vol.2, pp.661-665, 2000.

D. P. Bazett-jones, R. Li, E. Fussner, R. Nisman, and H. Dehghani, Elucidating chromatin and nuclear domain architecture with electron spectroscopic imaging, Chromosome Research, vol.164, issue.4, pp.397-412, 2008.
DOI : 10.1007/s10577-008-1237-3

G. Dellaire, R. Kepkay, and D. P. Bazett-jones, High resolution imaging of changes in the structure and spatial organization of chromatin, ??-H2A.X and the MRN complex within etoposide-induced DNA repair foci, Cell Cycle, vol.8, issue.22, pp.3750-3769, 2009.
DOI : 10.4161/cc.8.22.10065

C. Molenaar, K. Wiesmeijer, N. P. Verwoerd, S. Khazen, R. Eils et al., Visualizing telomere dynamics in living mammalian cells using PNA probes, The EMBO Journal, vol.59, issue.24, pp.6631-6641, 2003.
DOI : 10.1073/pnas.94.14.7423

K. Richter, M. Nessling, and P. Lichter, Macromolecular crowding and its potential impact on nuclear function, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1783, issue.11, pp.2100-2107, 2008.
DOI : 10.1016/j.bbamcr.2008.07.017

A. M. Glauert and P. R. Lewis, Biological Specimen Preparation for Transmission Electron Microscopy, 1998.
DOI : 10.1515/9781400865024

J. Dubochet, The Physics of Rapid Cooling and Its Implications for Cryoimmobilization of Cells, Methods Cell. Biol, vol.79, pp.7-21, 2007.
DOI : 10.1016/S0091-679X(06)79001-X

J. Dubochet, B. Zuber, M. Eltsov, C. Bouchet-marquis, A. Al-amoudi et al., How to ???Read??? a Vitreous Section, Methods Cell. Biol, vol.79, pp.385-406, 2007.
DOI : 10.1016/S0091-679X(06)79015-X

E. Betzig, G. H. Patterson, R. Sougrat, O. W. Lindwasser, S. Olenych et al., Imaging Intracellular Fluorescent Proteins at Nanometer Resolution, Science, vol.313, issue.5793, pp.1642-1645, 2006.
DOI : 10.1126/science.1127344

S. W. Hell, Toward fluorescence nanoscopy, Nature Biotechnology, vol.21, issue.11, pp.1347-1355, 2003.
DOI : 10.1038/nbt895

M. J. Rust, M. Bates, and X. Zhuang, Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM), Nature Methods, vol.127, issue.10, pp.793-795, 2006.
DOI : 10.1038/nmeth929

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700296

J. Foïling, M. Bossi, H. Bock, R. Medda, C. A. Wurm et al., Fluorescence nanoscopy by ground-state depletion and single-molecule return, Nature Methods, vol.19, issue.11, pp.943-945, 2008.
DOI : 10.1038/41048

M. Bohn, P. Diesinger, R. Kaufmann, Y. Weiland, P. Muïler et al., Localization Microscopy Reveals Expression-Dependent Parameters of??Chromatin Nanostructure, Biophysical Journal, vol.99, issue.5, pp.1358-1367, 2010.
DOI : 10.1016/j.bpj.2010.05.043

R. Wombacher, M. Heidberder, S. Van-de-linde, M. P. Sheetz, M. Heilemann et al., Live-cell super-resolution imaging with trimethoprim conjugates, Nature Methods, vol.37, issue.9, pp.717-719, 2010.
DOI : 10.1038/nmeth.1489

H. Hajjoul, S. Kocanova, I. Lassadi, K. Bystricky, and A. Bancaud, Lab-on-Chip for fast 3D particle tracking in living cells, Lab on a Chip, vol.83, issue.9, pp.3054-3058, 2009.
DOI : 10.1039/b909016a

V. Levi, Q. Ruan, and E. Gratton, 3-D Particle Tracking in a Two-Photon Microscope: Application to the Study of Molecular Dynamics in Cells, Biophysical Journal, vol.88, issue.4, pp.2919-2928, 2005.
DOI : 10.1529/biophysj.104.044230

J. Elf, G. Li, and X. S. Xie, Probing Transcription Factor Dynamics at the Single-Molecule Level in a Living Cell, Science, vol.316, issue.5828, pp.316-1191, 2007.
DOI : 10.1126/science.1141967

B. Harke, C. K. Ullal, J. Keller, and S. W. Hell, Three-Dimensional Nanoscopy of Colloidal Crystals, Nano Letters, vol.8, issue.5, pp.1309-1313, 2008.
DOI : 10.1021/nl073164n

M. Dahan, S. Le´vile´vi, C. Luccardini, P. Rostaing, B. Riveau et al., Diffusion Dynamics of Glycine Receptors Revealed by Single-Quantum Dot Tracking, Science, vol.302, issue.5644, pp.442-445, 2003.
DOI : 10.1126/science.1088525

URL : https://hal.archives-ouvertes.fr/hal-00002449

A. Bruckbauer, P. James, H. Zhou, J. W. Yoon, D. Excell et al., Nanopipette Delivery of Individual Molecules to Cellular Compartments for Single-Molecule Fluorescence Tracking, Biophysical Journal, vol.93, issue.9, pp.3120-3131, 2007.
DOI : 10.1529/biophysj.107.104737

M. Botta, S. Haider, I. X. Leung, P. Lio, and J. Mozziconacci, Intra-and inter-chromosomal interactions correlated with CTCF binding genome wide, Mol. Syst. Biol, vol.6, p.426, 2010.

O. Benichou, C. Chevalier, B. Meyer, and R. Voituriez, Facilitated Diffusion of Proteins on Chromatin, Physical Review Letters, vol.106, issue.3, p.38102, 2011.
DOI : 10.1103/PhysRevLett.106.038102