 |
Journal articles
A fractal model for nuclear organization: current evidence and biological implications.
Abstract : Chromatin is a multiscale structure on which transcription, replication, recombination and repair of the genome occur. To fully understand any of these processes at the molecular level under physiological conditions, a clear picture of the polymorphic and dynamic organization of chromatin in the eukaryotic nucleus is required. Recent studies indicate that a fractal model of chromatin architecture is consistent with both the reaction-diffusion properties of chromatin interacting proteins and with structural data on chromatin interminglement. In this study, we provide a critical overview of the experimental evidence that support a fractal organization of chromatin. On this basis, we discuss the functional implications of a fractal chromatin model for biological processes and propose future experiments to probe chromatin organization further that should allow to strongly support or invalidate the fractal hypothesis.
Cited literature [94 references]
https://www.hal.inserm.fr/inserm-00718260
Contributor : Hervé de Villemeur <>
Submitted on : Tuesday, July 16, 2013 - 7:00:04 AM
Last modification on : Tuesday, November 17, 2020 - 12:50:06 PM
Long-term archiving on: : Thursday, October 17, 2013 - 3:00:10 AM
Contributor : Hervé de Villemeur <>
Submitted on : Tuesday, July 16, 2013 - 7:00:04 AM
Last modification on : Tuesday, November 17, 2020 - 12:50:06 PM
Long-term archiving on: : Thursday, October 17, 2013 - 3:00:10 AM
File
nar.gks586.full.pdf
Publisher files allowed on an open archive