Skip to Main content Skip to Navigation
Journal articles

A fractal model for nuclear organization: current evidence and biological implications.

Abstract : Chromatin is a multiscale structure on which transcription, replication, recombination and repair of the genome occur. To fully understand any of these processes at the molecular level under physiological conditions, a clear picture of the polymorphic and dynamic organization of chromatin in the eukaryotic nucleus is required. Recent studies indicate that a fractal model of chromatin architecture is consistent with both the reaction-diffusion properties of chromatin interacting proteins and with structural data on chromatin interminglement. In this study, we provide a critical overview of the experimental evidence that support a fractal organization of chromatin. On this basis, we discuss the functional implications of a fractal chromatin model for biological processes and propose future experiments to probe chromatin organization further that should allow to strongly support or invalidate the fractal hypothesis.
Complete list of metadata

Cited literature [94 references]  Display  Hide  Download
Contributor : Hervé De Villemeur Connect in order to contact the contributor
Submitted on : Tuesday, July 16, 2013 - 7:00:04 AM
Last modification on : Monday, July 4, 2022 - 10:00:24 AM
Long-term archiving on: : Thursday, October 17, 2013 - 3:00:10 AM


Publisher files allowed on an open archive



Aurélien Bancaud, Christophe Lavelle, Sébastien Huet, Jan Ellenberg. A fractal model for nuclear organization: current evidence and biological implications.. Nucleic Acids Research, Oxford University Press, 2012, 40 (18), pp.8783-92. ⟨10.1093/nar/gks586⟩. ⟨inserm-00718260⟩



Record views


Files downloads