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Complete genome sequence of the strong mutator Salmonella enterica subsp. enterica serotype Heidelberg strain B182.

Abstract : In bacteria, normal mutation frequencies are mostly around 10(-10) per base pair. However, there exists natural isolates, called "mutators," that exhibit permanent mutation occurrences up to 1,000-fold greater than usual. As mutations play essential roles, particularly in the evolution of antibiotic resistance, bacteria showing elevated mutation rates could have an important responsibility in the emergence of antibiotic resistance, especially in the clinical background. In this announcement, we report the first complete genome sequence of the Salmonella enterica subsp. enterica serotype Heidelberg B182 mutator strain, isolated from bovine feces (France), which consists of a 4,750,465-bp circular chromosome (cB182_4750; GC, 52.2%) and one circular plasmid of 37,581 bp (pB182_37; GC, 42.8%).
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Hervé Le Bars, Latifa Bousarghin, Martine Bonnaure-Mallet, Anne Jolivet-Gougeon, Frédérique Barloy-Hubler. Complete genome sequence of the strong mutator Salmonella enterica subsp. enterica serotype Heidelberg strain B182.. Journal of Bacteriology, American Society for Microbiology, 2012, 194 (13), pp.3537-8. ⟨10.1128/JB.00498-12⟩. ⟨inserm-00716851⟩

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