Control of peptide nanotube diameter by chemical modifications of an aromatic residue involved in a single close contact. - Archive ouverte HAL Access content directly
Journal Articles Proceedings of the National Academy of Sciences of the United States of America Year : 2011

Control of peptide nanotube diameter by chemical modifications of an aromatic residue involved in a single close contact.

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Emilie Pouget
Cristelle Meriadec
Céline Valéry
  • Function : Author

Abstract

Supramolecular self-assembly is an attractive pathway for bottom-up synthesis of novel nanomaterials. In particular, this approach allows the spontaneous formation of structures of well-defined shapes and monodisperse characteristic sizes. Because nanotechnology mainly relies on size-dependent physical phenomena, the control of monodispersity is required, but the possibility of tuning the size is also essential. For self-assembling systems, shape, size, and monodispersity are mainly settled by the chemical structure of the building block. Attempts to change the size notably by chemical modification usually end up with the loss of self-assembly. Here, we generated a library of 17 peptides forming nanotubes of monodisperse diameter ranging from 10 to 36 nm. A structural model taking into account close contacts explains how a modification of a few Å of a single aromatic residue induces a fourfold increase in nanotube diameter. The application of such a strategy is demonstrated by the formation of silica nanotubes of various diameters.

Dates and versions

inserm-00716817 , version 1 (11-07-2012)

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Cite

Christophe Tarabout, Stéphane Roux, Frédéric Gobeaux, Nicolas Fay, Emilie Pouget, et al.. Control of peptide nanotube diameter by chemical modifications of an aromatic residue involved in a single close contact.. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (19), pp.7679-84. ⟨10.1073/pnas.1017343108⟩. ⟨inserm-00716817⟩
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