Skip to Main content Skip to Navigation
Journal articles

On the facultative requirement of the bacterial RNA chaperone, Hfq.

Abstract : The pleiotropic post-transcriptional regulator Hfq is an RNA chaperone that facilitates pairing interactions between small regulatory RNAs (sRNAs) and their mRNA targets in several bacteria. However, this classical pattern, derived from the Escherichia coli model, is not applicable to the whole bacterial kingdom. In this article we discuss the facultative requirement for Hfq for sRNA-mRNA duplex formation among bacteria and the specific features of the Hfq protein and RNA duplexes that might account for the dispensability or requirement of the chaperone. Apparent links between the need for Hfq, the GC content of bacterial genomes and the free energy of experimentally validated sRNA-mRNA pairing interactions are presented.
Document type :
Journal articles
Complete list of metadata

Cited literature [59 references]  Display  Hide  Download
Contributor : Annick Lefevre Connect in order to contact the contributor
Submitted on : Tuesday, June 26, 2012 - 3:03:17 PM
Last modification on : Wednesday, March 30, 2022 - 2:34:24 PM
Long-term archiving on: : Thursday, September 27, 2012 - 2:41:51 AM


Publisher files allowed on an open archive



Ambre Jousselin, Laurent Metzinger, Brice Felden. On the facultative requirement of the bacterial RNA chaperone, Hfq.. Trends Microbiol, 2009, 17 (9), pp.399-405. ⟨10.1016/j.tim.2009.06.003⟩. ⟨inserm-00712130⟩



Record views


Files downloads