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Journal articles
Synthesis and biological evaluation of novel ferrocenyl curcuminoid derivatives
Abstract : With the purpose to improve the biological activities of curcumin, eight novel ferrocenyl curcuminoids were synthesized by covalent anchorage of three different ferrocenyl ligands. We evaluated their cytotoxicity on B16 melanoma cells and normal NIH 3T3 cells, their inhibition of tubulin polymerization and their effect on the morphology of endothelial cells. The presence of a ferrocenyl side chain was clearly shown to improve the biological activity of most of their corresponding organic curcuminoid analogues.
Cited literature [18 references]
https://www.hal.inserm.fr/inserm-00709892
Contributor : Guy Chabot <>
Submitted on : Tuesday, June 19, 2012 - 4:15:20 PM
Last modification on : Tuesday, September 22, 2020 - 3:58:45 AM
Long-term archiving on: : Thursday, September 20, 2012 - 2:40:15 AM
Contributor : Guy Chabot <>
Submitted on : Tuesday, June 19, 2012 - 4:15:20 PM
Last modification on : Tuesday, September 22, 2020 - 3:58:45 AM
Long-term archiving on: : Thursday, September 20, 2012 - 2:40:15 AM
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