Synthesis and biological evaluation of novel ferrocenyl curcuminoid derivatives

Abstract : With the purpose to improve the biological activities of curcumin, eight novel ferrocenyl curcuminoids were synthesized by covalent anchorage of three different ferrocenyl ligands. We evaluated their cytotoxicity on B16 melanoma cells and normal NIH 3T3 cells, their inhibition of tubulin polymerization and their effect on the morphology of endothelial cells. The presence of a ferrocenyl side chain was clearly shown to improve the biological activity of most of their corresponding organic curcuminoid analogues.
Type de document :
Article dans une revue
MedChemComm, Royal Society of Chemistry, 2011, 2 (3), pp.190-195. 〈10.1039/c0md00231c〉
Liste complète des métadonnées

Littérature citée [18 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00709892
Contributeur : Guy Chabot <>
Soumis le : mardi 19 juin 2012 - 16:15:20
Dernière modification le : mercredi 21 mars 2018 - 18:57:38
Document(s) archivé(s) le : jeudi 20 septembre 2012 - 02:40:15

Fichiers

inserm-00709892_edited.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Citation

Anusch Arezki, Guy Chabot, Lionel Quentin, Daniel Scherman, Gérard Jaouen, et al.. Synthesis and biological evaluation of novel ferrocenyl curcuminoid derivatives. MedChemComm, Royal Society of Chemistry, 2011, 2 (3), pp.190-195. 〈10.1039/c0md00231c〉. 〈inserm-00709892〉

Partager

Métriques

Consultations de la notice

484

Téléchargements de fichiers

882