Evolution of mutational robustness in an RNA virus.

Abstract : Mutational (genetic) robustness is phenotypic constancy in the face of mutational changes to the genome. Robustness is critical to the understanding of evolution because phenotypically expressed genetic variation is the fuel of natural selection. Nonetheless, the evidence for adaptive evolution of mutational robustness in biological populations is controversial. Robustness should be selectively favored when mutation rates are high, a common feature of RNA viruses. However, selection for robustness may be relaxed under virus co-infection because complementation between virus genotypes can buffer mutational effects. We therefore hypothesized that selection for genetic robustness in viruses will be weakened with increasing frequency of co-infection. To test this idea, we used populations of RNA phage phi6 that were experimentally evolved at low and high levels of co-infection and subjected lineages of these viruses to mutation accumulation through population bottlenecking. The data demonstrate that viruses evolved under high co-infection show relatively greater mean magnitude and variance in the fitness changes generated by addition of random mutations, confirming our hypothesis that they experience weakened selection for robustness. Our study further suggests that co-infection of host cells may be advantageous to RNA viruses only in the short term. In addition, we observed higher mutation frequencies in the more robust viruses, indicating that evolution of robustness might foster less-accurate genome replication in RNA viruses.
Type de document :
Article dans une revue
PLoS Biology, Public Library of Science, 2005, 3 (11), pp.e381. 〈10.1371/journal.pbio.0030381〉
Liste complète des métadonnées

Littérature citée [27 références]  Voir  Masquer  Télécharger

Contributeur : Delphine Autard <>
Soumis le : vendredi 15 juin 2012 - 10:07:51
Dernière modification le : lundi 4 décembre 2017 - 10:36:41
Document(s) archivé(s) le : dimanche 16 septembre 2012 - 02:26:19


Fichiers éditeurs autorisés sur une archive ouverte




Rebecca Montville, Remy Froissart, Susanna Remold, Olivier Tenaillon, Paul Turner. Evolution of mutational robustness in an RNA virus.. PLoS Biology, Public Library of Science, 2005, 3 (11), pp.e381. 〈10.1371/journal.pbio.0030381〉. 〈inserm-00708445〉



Consultations de la notice


Téléchargements de fichiers