G. Tononi and C. Cirelli, Sleep function and synaptic homeostasis, Sleep Medicine Reviews, vol.10, issue.1, pp.49-62, 2006.
DOI : 10.1016/j.smrv.2005.05.002

J. Siegel, Clues to the functions of mammalian sleep, Nature, vol.31, issue.7063, pp.1264-1271, 2005.
DOI : 10.1016/0304-3940(87)90684-7

W. Joiner, A. Crocker, B. White, and A. Sehgal, Sleep in Drosophila is regulated by adult mushroom bodies, Nature, vol.80, issue.7094, pp.757-760, 2006.
DOI : 10.1038/nature04811

P. Shaw, C. Cirelli, R. Greenspan, and G. Tononi, Correlates of Sleep and Waking in Drosophila melanogaster, Science, vol.287, issue.5459, pp.1834-1837, 2000.
DOI : 10.1126/science.287.5459.1834

C. Cirelli, D. Bushey, S. Hill, R. Huber, and R. Kreber, Reduced sleep in Drosophila Shaker mutants, Nature, vol.7, issue.7037, pp.1087-1092, 2005.
DOI : 10.1186/1471-2202-3-1

S. Campbell and I. Tobler, Animal sleep: A review of sleep duration across phylogeny, Neuroscience & Biobehavioral Reviews, vol.8, issue.3, pp.269-300, 1984.
DOI : 10.1016/0149-7634(84)90054-X

I. Tobler and A. Borbely, Effect of rest deprivation on motor activity of fish, Journal of Comparative Physiology A, vol.8, issue.6, pp.817-822, 1985.
DOI : 10.1007/BF01350078

D. Nitz, B. Van-swinderen, G. Tononi, and R. Greenspan, Electrophysiological Correlates of Rest and Activity in Drosophila melanogaster, Current Biology, vol.12, issue.22, pp.1934-1940, 2002.
DOI : 10.1016/S0960-9822(02)01300-3

S. Saraswati, L. Fox, D. Soll, and C. Wu, Tyramine and octopamine have opposite effects on the locomotion ofDrosophila larvae, Journal of Neurobiology, vol.24, issue.4, pp.425-441, 2004.
DOI : 10.1002/neu.10298

L. De-lecea, T. Kilduff, C. Peyron, X. Gao, and P. Foye, The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity, Proceedings of the National Academy of Sciences, vol.95, issue.1, pp.322-327, 1998.
DOI : 10.1073/pnas.95.1.322

T. Sakurai, A. Amemiya, M. Ishii, I. Matsuzaki, and R. Chemelli, Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior, Cell, vol.92, issue.4, pp.1-696, 1998.
DOI : 10.1016/S0092-8674(00)80949-6

L. Lin, J. Faraco, R. Li, H. Kadotani, and W. Rogers, The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene, Cell, vol.98, issue.3, pp.365-376, 1999.
DOI : 10.1016/S0092-8674(00)81965-0

S. Nishino, B. Ripley, S. Overeem, G. Lammers, and E. Mignot, Hypocretin (orexin) deficiency in human narcolepsy, The Lancet, vol.355, issue.9197, pp.39-40, 2000.
DOI : 10.1016/S0140-6736(99)05582-8

C. Peyron, J. Faraco, R. W. Ripley, B. Overeem, and S. , A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains, Nat Med, vol.6, pp.991-997, 2000.

R. Chemelli, J. Willie, C. Sinton, J. Elmquist, and T. Scammell, Narcolepsy in orexin Knockout Mice, Cell, vol.98, issue.4, pp.437-451, 1999.
DOI : 10.1016/S0092-8674(00)81973-X

T. Thannickal, R. Moore, R. Nienhuis, L. Ramanathan, and S. Gulyani, Reduced Number of Hypocretin Neurons in Human Narcolepsy, Neuron, vol.27, issue.3, pp.469-474, 2000.
DOI : 10.1016/S0896-6273(00)00058-1

E. Mignot, G. Lammers, R. B. Okun, M. Nevsimalova, and S. , The Role of Cerebrospinal Fluid Hypocretin Measurement in the Diagnosis of Narcolepsy and Other Hypersomnias, Archives of Neurology, vol.59, issue.10, pp.1553-1562, 2002.
DOI : 10.1001/archneur.59.10.1553

C. Peyron, D. Tighe, A. Van-den-pol, L. De-lecea, and H. Heller, Neurons containing hypocretin (orexin) project to multiple neuronal systems, J Neurosci, vol.18, pp.9996-10015, 1998.

J. Marcus, C. Aschkenasi, C. Lee, R. Chemelli, and C. Saper, Differential expression of orexin receptors 1 and 2 in the rat brain, The Journal of Comparative Neurology, vol.267, issue.1, pp.6-25, 2001.
DOI : 10.1002/cne.1190

T. Horvath, C. Peyron, S. Diano, A. Ivanov, and G. Aston-jones, Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system, The Journal of Comparative Neurology, vol.280, issue.2, pp.145-159, 1999.
DOI : 10.1002/(SICI)1096-9861(19991213)415:2<145::AID-CNE1>3.0.CO;2-2

N. Vittoz and C. Berridge, Hypocretin/Orexin Selectively Increases Dopamine Efflux within the Prefrontal Cortex: Involvement of the Ventral Tegmental Area, Neuropsychopharmacology, vol.24, issue.2, pp.384-395, 2006.
DOI : 10.1038/sj.npp.1300807

R. Brown, O. Sergeeva, K. Eriksson, and H. Haas, Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin/hypocretin, histamine and noradrenaline), J Neurosci, vol.22, pp.8850-8859, 2002.

K. Eriksson, O. Sergeeva, R. Brown, and H. Haas, Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus, J Neurosci, vol.21, pp.9273-9279, 2001.

S. Burlet, C. Tyler, and C. Leonard, Direct and indirect excitation of laterodorsal tegmental neurons by Hypocretin/Orexin peptides: Implications for wakefulness and narcolepsy, J Neurosci, vol.22, pp.2862-2872, 2002.

R. Brown, S. Winston, R. Basheer, M. Thakkar, and R. Mccarley, Electrophysiological characterization of neurons in the dorsolateral pontine rapid-eye-movement sleep induction zone of the rat: Intrinsic membrane properties and responses to carbachol and orexins, Neuroscience, vol.143, issue.3, pp.739-755, 2006.
DOI : 10.1016/j.neuroscience.2006.08.045

M. Wu, L. Zaborszky, T. Hajszan, A. Van-den-pol, and M. Alreja, Hypocretin/Orexin Innervation and Excitation of Identified Septohippocampal Cholinergic Neurons, Journal of Neuroscience, vol.24, issue.14, pp.3527-3536, 2004.
DOI : 10.1523/JNEUROSCI.5364-03.2004

N. Fujiki, Y. Yoshida, B. Ripley, E. Mignot, and S. Nishino, Effects of IV and ICV hypocretin-1 (orexin A) in hypocretin receptor-2 gene mutated narcoleptic dogs and IV hypocretin-1 replacement therapy in a hypocretinligand-deficient narcoleptic dog, Sleep, vol.26, pp.953-959, 2003.

A. Yamanaka, N. Tsujino, H. Funahashi, K. Honda, and J. Guan, Orexins Activate Histaminergic Neurons via the Orexin 2 Receptor, Biochemical and Biophysical Research Communications, vol.290, issue.4, pp.1237-1245, 2002.
DOI : 10.1006/bbrc.2001.6318

J. Zeitzer and E. Mignot, Role of hypocretin/orexin in the neurobiology of sleep and alterness, Narcolepsy and hypersomnia, pp.359-371, 2007.

T. Nakamura, K. Uramura, T. Nambu, T. Yada, and K. Goto, Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system11Published on the World Wide Web on 27 June 2000., Brain Research, vol.873, issue.1, pp.181-187, 2000.
DOI : 10.1016/S0006-8993(00)02555-5

M. Okun, L. Lin, Z. Pelin, S. Hong, and E. Mignot, Clinical aspects of narcolepsy-cataplexy across ethnic groups, Sleep, vol.25, pp.27-35, 2002.

S. Overeem, E. Mignot, J. Van-dijk, and G. Lammers, Narcolepsy, Sleep Medicine Clinics, vol.7, issue.2, pp.78-105, 2001.
DOI : 10.1016/j.jsmc.2012.03.013
URL : https://hal.archives-ouvertes.fr/inserm-01484949

Y. Hishikawa, H. Wakamatsu, E. Furuya, Y. Sugita, and S. Masaoka, Sleep satiation in narcoleptic patients, Electroencephalography and Clinical Neurophysiology, vol.41, issue.1, pp.1-18, 1976.
DOI : 10.1016/0013-4694(76)90210-8

M. Billiard, M. Salva, D. Koninck, J. Besset, A. Touchon et al., Daytime sleep characteristics and their relationships with night sleep in the narcoleptic patient, Sleep, vol.9, pp.167-174, 1986.

J. Zeitzer, C. Buckmaster, K. Parker, C. Hauck, and D. Lyons, Circadian and homeostatic regulation of hypocretin in a primate model: Implications for the consolidation of wakefulness, J Neurosci, vol.23, pp.3555-3560, 2003.

S. Nishino and E. Mignot, PHARMACOLOGICAL ASPECTS OF HUMAN AND CANINE NARCOLEPSY, Progress in Neurobiology, vol.52, issue.1, pp.27-78, 1997.
DOI : 10.1016/S0301-0082(96)00070-6

B. Ripley, N. Fujiki, M. Okura, E. Mignot, and S. Nishino, Hypocretin Levels in Sporadic and Familial Cases of Canine Narcolepsy, Neurobiology of Disease, vol.8, issue.3, pp.525-534, 2001.
DOI : 10.1006/nbdi.2001.0389

C. Beuckmann, C. Sinton, S. Williams, J. Richardson, and R. Hammer, Expression of a Poly-Glutamine-Ataxin-3 Transgene in Orexin Neurons Induces Narcolepsy-Cataplexy in the Rat, Journal of Neuroscience, vol.24, issue.18, pp.4469-4477, 2004.
DOI : 10.1523/JNEUROSCI.5560-03.2004

J. Willie, R. Chemelli, C. Sinton, S. Tokita, and S. Williams, Distinct Narcolepsy Syndromes in Orexin Receptor-2 and Orexin Null Mice, Neuron, vol.38, issue.5, pp.715-730, 2003.
DOI : 10.1016/S0896-6273(03)00330-1

J. Willie and M. Yanagisawa, Lessons from sleepy mice: Narcolepsycataplexy and the orexin neuropeptide system, Narcolepsy and hypersomnia, pp.257-278, 2007.

T. Mueller and M. Wullimannn, Atlas of early zebrafish brain development: A tool for molecular neurogenetics, 2005.
URL : https://hal.archives-ouvertes.fr/hal-00113800

M. Wullimann, B. Rupp, and H. Reichter, Neuroanatomy of the zebrafish brain: A topological atlas, 1996.
DOI : 10.1007/978-3-0348-8979-7

J. Kaslin and P. Panula, Comparative anatomy of the histaminergic and other aminergic systems in zebrafish (Danio rerio), The Journal of Comparative Neurology, vol.330, issue.4, pp.342-377, 2001.
DOI : 10.1002/cne.1390

J. Holzschuh, S. Ryu, F. Aberger, and W. Driever, Dopamine transporter expression distinguishes dopaminergic neurons from other catecholaminergic neurons in the developing zebrafish embryo, Mechanisms of Development, vol.101, issue.1-2, pp.237-243, 2001.
DOI : 10.1016/S0925-4773(01)00287-8

H. Teraoka, C. Russell, J. Regan, A. Chandrasekhar, and M. Concha, Hedgehog and Fgf signaling pathways regulate the development oftphR-expressing serotonergic raphe neurons in zebrafish embryos, Journal of Neurobiology, vol.93, issue.3, pp.275-288, 2004.
DOI : 10.1002/neu.20023

D. Mclean and J. Fetcho, Ontogeny and innervation patterns of dopaminergic, noradrenergic, and serotonergic neurons in larval zebrafish, The Journal of Comparative Neurology, vol.199, issue.1, pp.38-56, 2004.
DOI : 10.1002/cne.20280

T. Mueller, P. Vernier, and M. Wullimann, The adult central nervous cholinergic system of a neurogenetic model animal, the zebrafish Danio rerio, Brain Research, vol.1011, issue.2, pp.156-169, 2004.
DOI : 10.1016/j.brainres.2004.02.073
URL : https://hal.archives-ouvertes.fr/hal-00121749

J. Faraco, L. Appelbaum, W. Marin, S. Gaus, and P. Mourrain, Regulation of Hypocretin (Orexin) Expression in Embryonic Zebrafish, Journal of Biological Chemistry, vol.281, issue.40, pp.29753-29761, 2006.
DOI : 10.1074/jbc.M605811200

J. Kaslin, J. Nystedt, M. Ostergard, N. Peitsaro, and P. Panula, The Orexin/Hypocretin System in Zebrafish Is Connected to the Aminergic and Cholinergic Systems, Journal of Neuroscience, vol.24, issue.11, pp.2678-2689, 2004.
DOI : 10.1523/JNEUROSCI.4908-03.2004

D. Prober, J. Rihel, A. Onah, R. Sung, and A. Schier, Hypocretin/Orexin Overexpression Induces An Insomnia-Like Phenotype in Zebrafish, Journal of Neuroscience, vol.26, issue.51, pp.13400-13410, 2006.
DOI : 10.1523/JNEUROSCI.4332-06.2006

I. Zhdanova, S. Wang, O. Leclair, and N. Danilova, Melatonin promotes sleep-like state in zebrafish, Brain Research, vol.903, issue.1-2, pp.263-268, 2001.
DOI : 10.1016/S0006-8993(01)02444-1

C. Renier, J. Faraco, P. Bourgin, T. Motley, and P. Bonaventure, Genomic and functional conservation of sedative-hypnotic targets in the zebrafish, Pharmacogenetics and Genomics, vol.17, issue.4, pp.237-253, 2007.
DOI : 10.1097/FPC.0b013e3280119d62

J. Ruuskanen, N. Peitsaro, J. Kaslin, P. Panula, and M. Scheinin, Expression and function of alpha2-adrenoceptors in zebrafish: drug effects, mRNA and receptor distributions, Journal of Neurochemistry, vol.110, issue.6, pp.1559-1569, 2005.
DOI : 10.1046/j.1460-9568.1999.00464.x

I. Zhdanova, Sleep in Zebrafish, Zebrafish, vol.3, issue.2, pp.215-226, 2006.
DOI : 10.1089/zeb.2006.3.215

R. Berger and N. Phillips, Energy conservation and sleep, Behavioural Brain Research, vol.69, issue.1-2, pp.65-73, 1995.
DOI : 10.1016/0166-4328(95)00002-B

H. Kraemer, Evaluating medical tests: Objective and quantitative guidelines, 1992.

M. Hurd, J. Debruyne, M. Straume, and G. Cahill, Circadian Rhythms of Locomotor Activity in Zebrafish, Physiology & Behavior, vol.65, issue.3, pp.465-472, 1998.
DOI : 10.1016/S0031-9384(98)00183-8

J. Lu, D. Sherman, M. Devor, and C. Saper, A putative flip???flop switch for control of REM sleep, Nature, vol.23, issue.7093, pp.589-594, 2006.
DOI : 10.1038/nature04767

T. Grudt, A. Van-den-pol, and E. Perl, Hypocretin-2 (orexin-B) modulation of superficial dorsal horn activity in rat, The Journal of Physiology, vol.482, issue.2, pp.517-525, 2002.
DOI : 10.1113/jphysiol.2001.013120

A. Van-den-pol, Hypothalamic hypocretin (orexin): Robust innervation of the spinal cord, J Neurosci, vol.19, pp.3171-3182, 1999.

Y. Date, M. Mondal, S. Matsukura, and M. Nakazato, Distribution of orexin-A and orexin-B (hypocretins) in the rat spinal cord, Neuroscience Letters, vol.288, issue.2, pp.87-90, 2000.
DOI : 10.1016/S0304-3940(00)01195-2

J. Mobarakeh, K. Takahashi, S. Sakurada, S. Nishino, and H. Watanabe, Enhanced antinociception by intracerebroventricularly and intrathecally-administered orexin A and B (hypocretin-1 and -2) in mice, Peptides, vol.26, issue.5, pp.767-777, 2005.
DOI : 10.1016/j.peptides.2005.01.001

T. Mochizuki, A. Crocker, S. Mccormack, M. Yanagisawa, and T. Sakurai, Behavioral State Instability in Orexin Knock-Out Mice, Journal of Neuroscience, vol.24, issue.28, pp.6291-6300, 2004.
DOI : 10.1523/JNEUROSCI.0586-04.2004

Y. Yoshida, N. Fujiki, R. Maki, D. Schwarz, and S. Nishino, Differential kinetics of hypocretins in the cerebrospinal fluid after intracerebroventricular administration in rats, Neuroscience Letters, vol.346, issue.3, pp.182-186, 2003.
DOI : 10.1016/S0304-3940(03)00571-8

T. Abe, T. Ishikawa, T. Masuda, K. Mizusawa, and T. Tsukamoto, Molecular analysis of Dec1 and Dec2 in the peripheral circadian clock of zebrafish photosensitive cells, Biochemical and Biophysical Research Communications, vol.351, issue.4, pp.1072-1077, 2006.
DOI : 10.1016/j.bbrc.2006.10.172

J. Plautz, M. Kaneko, J. Hall, and S. Kay, Independent Photoreceptive Circadian Clocks Throughout Drosophila, Science, vol.278, issue.5343, pp.1632-1635, 1997.
DOI : 10.1126/science.278.5343.1632

N. Rattenborg, B. Mandt, W. Obermeyer, P. Winsauer, and R. Huber, Migratory Sleeplessness in the White-Crowned Sparrow (Zonotrichia leucophrys gambelii), PLoS Biology, vol.159, issue.7, p.212, 2004.
DOI : 10.1371/journal.pbio.0020212.s004

N. Rattenborg, W. Obermeyer, E. Vacha, and R. Benca, Acute effects of light and darkness on sleep in the pigeon (Columba livia)???, Physiology & Behavior, vol.84, issue.4, pp.635-640, 2005.
DOI : 10.1016/j.physbeh.2005.02.009

R. Berger and N. Phillips, Constant light suppresses sleep and circadian rhythms in pigeons without consequent sleep rebound in darkness, Am J Physiol, vol.267, pp.945-952, 1994.

I. Tobler and A. Borbely, Sleep and EEG spectra in the pigeon (Columba livia) under baseline conditions and after sleep deprivation, Journal of Comparative Physiology A, vol.11, issue.6, pp.729-738, 1988.
DOI : 10.1007/BF00604050

E. Mintz, N. Phillips, and R. Berger, Daytime melatonin infusions induce sleep in pigeons without altering subsequent amounts of nocturnal sleep, Neuroscience Letters, vol.258, issue.2, pp.61-64, 1998.
DOI : 10.1016/S0304-3940(98)00849-0

S. Asahi, S. Egashira, M. Matsuda, H. Iwaasa, and A. Kanatani, Development of an orexin-2 receptor selective agonist, [Ala11, d-Leu15]orexin-B, Bioorganic & Medicinal Chemistry Letters, vol.13, issue.1, pp.111-113, 2003.
DOI : 10.1016/S0960-894X(02)00851-X

M. Shibahara, T. Sakurai, T. Nambu, T. Takenouchi, and H. Iwaasa, Structure, tissue distribution, and pharmacological characterization of Xenopus orexins, Peptides, vol.20, issue.10, pp.1169-1176, 1999.
DOI : 10.1016/S0196-9781(99)00120-5

T. Nakamachi, K. Matsuda, K. Maruyama, T. Miura, and M. Uchiyama, Regulation by Orexin of Feeding Behaviour and Locomotor Activity in the Goldfish, Journal of Neuroendocrinology, vol.557, issue.4, pp.290-297, 2006.
DOI : 10.1016/j.brainres.2005.05.045

A. Yamanaka, C. Beuckmann, J. Willie, J. Hara, and N. Tsujino, Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice, Neuron, vol.38, issue.5, pp.701-713, 2003.
DOI : 10.1016/S0896-6273(03)00331-3

S. Perez, J. Yanez, O. Marin, R. Anadon, and A. Gonzalez, Distribution of choline acetyltransferase (ChAT) immunoreactivity in the brain of the adult trout and tract-tracing observations on the connections of the nuclei of the isthmus, The Journal of Comparative Neurology, vol.273, issue.3, pp.450-474, 2000.
DOI : 10.1002/1096-9861(20001218)428:3<450::AID-CNE5>3.0.CO;2-T

R. Anadon, P. Molist, I. Rodriguez-moldes, J. Lopez, and I. Quintela, Distribution of choline acetyltransferase immunoreactivity in the brain of an elasmobranch, the lesser spotted dogfish (Scyliorhinus canicula), The Journal of Comparative Neurology, vol.273, issue.2, pp.139-170, 2000.
DOI : 10.1002/(SICI)1096-9861(20000501)420:2<139::AID-CNE1>3.0.CO;2-T

J. Zeitzer, C. Buckmaster, D. Lyons, and E. Mignot, Locomotor-dependent and -independent components to hypocretin-1 (orexin A) regulation in sleep-wake consolidating monkeys, The Journal of Physiology, vol.13, issue.S1, pp.1045-1053, 2004.
DOI : 10.1113/jphysiol.2004.061606

Z. Huang, W. Qu, W. Li, T. Mochizuki, and N. Eguchi, Arousal effect of orexin A depends on activation of the histaminergic system, Proceedings of the National Academy of Sciences, vol.98, issue.17, pp.9965-9970, 2001.
DOI : 10.1073/pnas.181330998

J. Siegel and L. Boehmer, Narcolepsy and the hypocretin system???where motion meets emotion, Nature Clinical Practice Neurology, vol.538, issue.2, pp.548-556, 2006.
DOI : 10.1038/ncpneuro0300

M. Modirrousta, L. Mainville, and B. Jones, Gabaergic neurons with ??2-adrenergic receptors in basal forebrain and preoptic area express c-Fos during sleep, Neuroscience, vol.129, issue.3, pp.803-810, 2004.
DOI : 10.1016/j.neuroscience.2004.07.028

E. Eggermann, M. Serafin, L. Bayer, D. Machard, and B. Saint-mleux, Orexins/hypocretins excite basal forebrain cholinergic neurones, Neuroscience, vol.108, issue.2, pp.177-181, 2001.
DOI : 10.1016/S0306-4522(01)00512-7

T. Chou, A. Bjorkum, S. Gaus, J. Lu, and T. Scammell, Afferents to the ventrolateral preoptic nucleus, J Neurosci, vol.22, pp.977-990, 2002.

J. Siegel, Phylogeny and the function of REM sleep, Behavioural Brain Research, vol.69, issue.1-2, pp.29-34, 1995.
DOI : 10.1016/0166-4328(95)00023-M

I. Karmanova, Evolution of sleep: Stages of the formation of the 'wakefulness-sleep' cycle in vertebrates, 1982.

J. Siegel, P. Manger, R. Nienhuis, H. Fahringer, and J. Pettigrew, The echidna Tachyglossus aculeatus combines REM and non-REM aspects in a single sleep state: Implications for the evolution of sleep, J Neurosci, vol.16, pp.3500-3506, 1996.

G. Hauptmann and T. Gerster, Two-color whole-mount in situ hybridization to vertebrate and Drosophila embryos, Trends Genet, vol.10, p.266, 1994.