Skip to Main content Skip to Navigation
Journal articles

Transient neuronal populations are required to guide callosal axons: a role for semaphorin 3C.

Abstract : The corpus callosum (CC) is the main pathway responsible for interhemispheric communication. CC agenesis is associated with numerous human pathologies, suggesting that a range of developmental defects can result in abnormalities in this structure. Midline glial cells are known to play a role in CC development, but we here show that two transient populations of midline neurons also make major contributions to the formation of this commissure. We report that these two neuronal populations enter the CC midline prior to the arrival of callosal pioneer axons. Using a combination of mutant analysis and in vitro assays, we demonstrate that CC neurons are necessary for normal callosal axon navigation. They exert an attractive influence on callosal axons, in part via Semaphorin 3C and its receptor Neuropilin-1. By revealing a novel and essential role for these neuronal populations in the pathfinding of a major cerebral commissure, our study brings new perspectives to pathophysiological mechanisms altering CC formation.
Document type :
Journal articles
Complete list of metadatas

Cited literature [76 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00707639
Contributor : Delphine Autard <>
Submitted on : Wednesday, June 13, 2012 - 11:04:55 AM
Last modification on : Tuesday, September 22, 2020 - 3:58:59 AM
Long-term archiving on: : Friday, September 14, 2012 - 2:25:50 AM

File

journal.pbio.1000230.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Mathieu Niquille, Sonia Garel, Fanny Mann, Jean-Pierre Hornung, Belkacem Otsmane, et al.. Transient neuronal populations are required to guide callosal axons: a role for semaphorin 3C.. PLoS Biology, Public Library of Science, 2009, 7 (10), pp.e1000230. ⟨10.1371/journal.pbio.1000230⟩. ⟨inserm-00707639⟩

Share

Metrics

Record views

529

Files downloads

565