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Human mucosal associated invariant T cells detect bacterially infected cells.

Abstract : Control of infection with Mycobacterium tuberculosis (Mtb) requires Th1-type immunity, of which CD8+ T cells play a unique role. High frequency Mtb-reactive CD8+ T cells are present in both Mtb-infected and uninfected humans. We show by limiting dilution analysis that nonclassically restricted CD8+ T cells are universally present, but predominate in Mtb-uninfected individuals. Interestingly, these Mtb-reactive cells expressed the Valpha7.2 T-cell receptor (TCR), were restricted by the nonclassical MHC (HLA-Ib) molecule MR1, and were activated in a transporter associated with antigen processing and presentation (TAP) independent manner. These properties are all characteristics of mucosal associated invariant T cells (MAIT), an "innate" T-cell population of previously unknown function. These MAIT cells also detect cells infected with other bacteria. Direct ex vivo analysis demonstrates that Mtb-reactive MAIT cells are decreased in peripheral blood mononuclear cells (PBMCs) from individuals with active tuberculosis, are enriched in human lung, and respond to Mtb-infected MR1-expressing lung epithelial cells. Overall, these findings suggest a generalized role for MAIT cells in the detection of bacterially infected cells, and potentially in the control of bacterial infection.
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Submitted on : Tuesday, June 12, 2012 - 2:34:11 PM
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Marielle C. Gold, Stefania Cerri, Susan Smyk-Pearson, Meghan E. Cansler, Todd M. Vogt, et al.. Human mucosal associated invariant T cells detect bacterially infected cells.. PLoS Biology, Public Library of Science, 2010, 8 (6), pp.e1000407. ⟨10.1371/journal.pbio.1000407⟩. ⟨inserm-00707307⟩



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