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Journal articles
Biologic modulation of ionizing radiation by Toll-like receptors agonists: Towards an increase in the therapeutic index of radiotherapy?
Abstract : Toll-like receptors are ubiquitous and very well conserved throughout evolution, with important functions mediating innate and adaptative immunological mechanisms. The importance of these receptors and their agonists has been recently pointed out in immunology and cancerology, although the accurate underlying mechanisms are still under investigation. The association of agonists of these receptors with ionizing radiation has been studied in preclinical experiments with promising results. Part of these compounds is flagellin, which seems to be able to modulate the radiosensitivity of both tumors and healthy tissues.
Cited literature [35 references]
https://www.hal.inserm.fr/inserm-00705691
Contributor : Yves Le Ster Connect in order to contact the contributor
Submitted on : Wednesday, May 1, 2013 - 7:00:14 AM
Last modification on : Tuesday, March 15, 2022 - 9:35:56 AM
Long-term archiving on: : Friday, August 2, 2013 - 2:20:09 AM
Contributor : Yves Le Ster Connect in order to contact the contributor
Submitted on : Wednesday, May 1, 2013 - 7:00:14 AM
Last modification on : Tuesday, March 15, 2022 - 9:35:56 AM
Long-term archiving on: : Friday, August 2, 2013 - 2:20:09 AM
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