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Biologic modulation of ionizing radiation by Toll-like receptors agonists: Towards an increase in the therapeutic index of radiotherapy?

Abstract : Toll-like receptors are ubiquitous and very well conserved throughout evolution, with important functions mediating innate and adaptative immunological mechanisms. The importance of these receptors and their agonists has been recently pointed out in immunology and cancerology, although the accurate underlying mechanisms are still under investigation. The association of agonists of these receptors with ionizing radiation has been studied in preclinical experiments with promising results. Part of these compounds is flagellin, which seems to be able to modulate the radiosensitivity of both tumors and healthy tissues.
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https://www.hal.inserm.fr/inserm-00705691
Contributor : Yves Le Ster <>
Submitted on : Wednesday, May 1, 2013 - 7:00:14 AM
Last modification on : Wednesday, October 3, 2018 - 4:02:07 PM
Long-term archiving on: : Friday, August 2, 2013 - 2:20:09 AM

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Olivier Riou, David Azria, Christel Larbouret, Bruno Robert. Biologic modulation of ionizing radiation by Toll-like receptors agonists: Towards an increase in the therapeutic index of radiotherapy?. Bulletin du Cancer, John Libbey Eurotext, 2012, 99 (5), pp.545-550. ⟨10.1684/bdc.2012.1578⟩. ⟨inserm-00705691⟩

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