L. Harrington, R. Hatton, P. Mangan, H. Turner, and T. Murphy, Interleukin 17???producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages, Nature Immunology, vol.173, issue.11, pp.1123-1155, 2005.
DOI : 10.1016/S1074-7613(00)80470-7

S. Hori, T. Nomura, and S. Sakaguchi, Control of Regulatory T Cell Development by the Transcription Factor Foxp3, Science, vol.299, issue.5609, pp.1057-61, 2003.
DOI : 10.1126/science.1079490

H. Park, Z. Li, X. Yang, S. Chang, and R. Nurieva, A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17, Nature Immunology, vol.103, issue.11, pp.1133-1174, 2005.
DOI : 10.1038/35051100

G. Kassiotis, O. Garra, and A. , Establishing the Follicular Helper Identity, Immunity, vol.31, issue.3, pp.450-452, 2009.
DOI : 10.1016/j.immuni.2009.08.017

V. Dardalhon, A. Awasthi, H. Kwon, G. Galileos, and W. Gao, IL-4 inhibits TGF-??-induced Foxp3+ T cells and, together with TGF-??, generates IL-9+ IL-10+ Foxp3??? effector T cells, Nature Immunology, vol.201, issue.12, pp.1347-55, 2008.
DOI : 10.1038/ni.1677

T. Mosmann and R. Coffman, TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties, Annual Review of Immunology, vol.7, issue.1, pp.145-73, 1989.
DOI : 10.1146/annurev.iy.07.040189.001045

L. Glimcher and K. Murphy, Lineage commitment in the immune system: the T helper lymphocyte grows up, Genes Dev, vol.14, pp.1693-711, 2000.

D. Vignali, L. Collison, and C. Workman, How regulatory T cells work, Nature Reviews Immunology, vol.178, issue.7, pp.523-555, 2008.
DOI : 10.1038/nri2343

I. Ivanov, B. Mckenzie, L. Zhou, C. Tadokoro, and A. Lepelley, The Orphan Nuclear Receptor ROR??t Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells, Cell, vol.126, issue.6, pp.1121-1154, 2006.
DOI : 10.1016/j.cell.2006.07.035

M. Veldhoen, C. Uyttenhove, J. Van-snick, H. Helmby, and A. Westendorf, Transforming growth factor-?? 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9???producing subset, Nature Immunology, vol.194, issue.12, pp.1341-1347, 2008.
DOI : 10.1038/ni.1659

L. Zhou, J. Lopes, M. Chong, I. Ivanov, and R. Min, TGF-??-induced Foxp3 inhibits TH17 cell differentiation by antagonizing ROR??t function, Nature, vol.288, issue.7192, pp.236-276, 2008.
DOI : 10.1038/nature06878

M. Koch, G. Tucker-heard, N. Perdue, J. Killebrew, and K. Urdahl, The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation, Nature Immunology, vol.446, issue.6, pp.595-602, 2009.
DOI : 10.1038/ni.1731

J. Duarte, S. Zelenay, M. Bergman, A. Martins, and J. Demengeot, Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions, European Journal of Immunology, vol.12, issue.4, pp.948-55, 2009.
DOI : 10.1002/eji.200839196

M. Fishman and A. Perelson, Th1/Th2 Cross Regulation, Journal of Theoretical Biology, vol.170, issue.1, pp.25-56, 1994.
DOI : 10.1006/jtbi.1994.1166

J. Carneiro, J. Stewart, A. Coutinho, and G. Coutinho, T lymphocyte populations, International Immunology, vol.7, issue.8, pp.1265-77, 1995.
DOI : 10.1093/intimm/7.8.1265

R. Bar-or and L. Segel, On the Role of a Possible Dialogue Between Cytokine and TCR-Presentation Mechanisms in the Regulation of Autoimmune Disease, Journal of Theoretical Biology, vol.190, issue.2, pp.161-78, 1998.
DOI : 10.1006/jtbi.1997.0545

C. Bergmann, J. Van-hemmen, and L. Segel, Th1 or Th2: How an Appropriate T Helper Response can be Made, Bulletin of Mathematical Biology, vol.63, issue.3, pp.405-435, 2001.
DOI : 10.1006/bulm.2000.0215

L. Mendoza, A network model for the control of the differentiation process in Th cells, Biosystems, vol.84, issue.2, pp.101-115, 2006.
DOI : 10.1016/j.biosystems.2005.10.004

M. Kaufman and R. Thomas, Model analysis of the bases of multistationarity in the humoral immune response, Journal of Theoretical Biology, vol.129, issue.2, pp.141-62, 1987.
DOI : 10.1016/S0022-5193(87)80009-7

T. Höfer, H. Nathansen, M. Löhning, A. Radbruch, and R. Heinrich, GATA-3 transcriptional imprinting in Th2 lymphocytes: A mathematical model, Proceedings of the National Academy of Sciences, vol.99, issue.14, pp.9364-9372, 2002.
DOI : 10.1073/pnas.142284699

H. Van-den-ham and R. De-boer, From the two-dimensional Th1 and Th2 phenotypes to high-dimensional models for gene regulation, International Immunology, vol.20, issue.10, pp.1269-77, 2008.
DOI : 10.1093/intimm/dxn093

A. Naldi, E. Remy, D. Thieffry, and C. Chaouiya, Dynamically consistent reduction of logical regulatory graphs, Theoretical Computer Science, vol.412, issue.21, 2010.
DOI : 10.1016/j.tcs.2010.10.021

URL : https://hal.archives-ouvertes.fr/hal-01284743

R. Thomas, D. Thieffry, and M. Kaufman, Dynamical behaviour of biological regulatory networks???I. Biological role of feedback loops and practical use of the concept of the loop-characteristic state, Bulletin of Mathematical Biology, vol.29, issue.2, pp.247-76, 1995.
DOI : 10.1007/BF02460618

C. Chaouiya, R. E. Mossé, B. Thieffry, and D. , Qualitative Analysis of Regulatory Graphs: A Computational Tool Based on a Discrete Formal Framework, Lect Notes Comput Inf Sci, vol.294, pp.119-145, 2003.
DOI : 10.1007/978-3-540-44928-7_17

A. Faure, A. Naldi, C. Chaouiya, and D. Thieffry, Dynamical analysis of a generic Boolean model for the control of the mammalian cell cycle, Bioinformatics, vol.22, issue.14, pp.124-155, 2006.
DOI : 10.1093/bioinformatics/btl210

URL : https://hal.archives-ouvertes.fr/hal-00310984

R. Thomas, On the Relation Between the Logical Structure of Systems and Their Ability to Generate Multiple Steady States or Sustained Oscillations, pp.180-93, 1981.
DOI : 10.1007/978-3-642-81703-8_24

D. Thieffry, Dynamical roles of biological regulatory circuits, Briefings in Bioinformatics, vol.8, issue.4, pp.220-225, 2007.
DOI : 10.1093/bib/bbm028

A. Naldi, D. Thieffry, and C. Chaouiya, Decision Diagrams for the Representation and Analysis of Logical Models of Genetic Networks, Lect Notes Comput Sci, vol.4695, pp.233-280, 2007.
DOI : 10.1007/978-3-540-75140-3_16

A. Naldi, D. Berenguier, A. Fauré, F. Lopez, and D. Thieffry, Logical modelling of regulatory networks with GINsim 2.3, Biosystems, vol.97, issue.2, pp.134-143, 2009.
DOI : 10.1016/j.biosystems.2009.04.008

J. Saez-rodriguez, L. Simeoni, J. Lindquist, R. Hemenway, and U. Bommhardt, A Logical Model Provides Insights into T Cell Receptor Signaling, PLoS Computational Biology, vol.284, issue.8, p.163, 2007.
DOI : 10.1371/journal.pcbi.0030163.st002

R. Moriggl, D. Topham, S. Teglund, V. Sexl, and C. Mckay, Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells, Immunity, vol.10, issue.2, pp.249-59, 1999.
DOI : 10.1016/S1074-7613(00)80025-4

H. Kim, J. Imbert, and W. Leonard, Both integrated and differential regulation of components of the IL-2/IL-2 receptor system, Cytokine & Growth Factor Reviews, vol.17, issue.5, pp.349-66, 2006.
DOI : 10.1016/j.cytogfr.2006.07.003

M. Burchill, Y. J. Vang, K. Farrar, and M. , Interleukin-2 receptor signaling in regulatory T cell development and homeostasis, Immunology Letters, vol.114, issue.1, pp.1-8, 2007.
DOI : 10.1016/j.imlet.2007.08.005

L. Mendoza and I. Xenarios, A method for the generation of standardized qualitative dynamical systems of regulatory networks, Theoretical Biology and Medical Modelling, vol.3, issue.1, p.13, 2006.
DOI : 10.1186/1742-4682-3-13

N. Komatsu, M. Mariotti-ferrandiz, Y. Wang, B. Malissen, and H. Waldmann, T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity, Proceedings of the National Academy of Sciences, vol.106, issue.6, pp.1903-1911, 2009.
DOI : 10.1073/pnas.0811556106

URL : https://hal.archives-ouvertes.fr/hal-00407810

M. Tsuji, N. Komatsu, S. Kawamoto, K. Suzuki, and O. Kanagawa, Preferential Generation of Follicular B Helper T Cells from Foxp3+ T Cells in Gut Peyer's Patches, Science, vol.323, issue.5920, pp.1488-92, 2009.
DOI : 10.1126/science.1169152

S. Floess, J. Freyer, C. Siewert, U. Baron, and S. Olek, Epigenetic Control of the foxp3 Locus in Regulatory T Cells, PLoS Biology, vol.31, issue.2, p.38, 2007.
DOI : 10.1371/journal.pbio.0050038.st001

X. Zhou, L. Jeker, B. Fife, S. Zhu, and M. Anderson, Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity, The Journal of Experimental Medicine, vol.27, issue.9, pp.1983-91, 2008.
DOI : 10.1006/geno.2000.6451

M. Kuczma, R. Podolsky, N. Garge, D. Daniely, and R. Pacholczyk, Foxp3-Deficient Regulatory T Cells Do Not Revert into Conventional Effector CD4+ T Cells but Constitute a Unique Cell Subset, The Journal of Immunology, vol.183, issue.6, pp.3731-3772, 2009.
DOI : 10.4049/jimmunol.0800601

K. León, R. Peréz, A. Lage, and J. Carneiro, Modelling T-cell-Mediated Suppression Dependent on Interactions in Multicellular Conjugates, Journal of Theoretical Biology, vol.207, issue.2, pp.231-54, 2000.
DOI : 10.1006/jtbi.2000.2169

J. Carneiro, K. Leon, I. Caramalho, C. Van-den-dool, and R. Gardner, T cells, Immunological Reviews, vol.6, issue.1, pp.48-68, 2007.
DOI : 10.1111/j.1600-065X.2007.00487.x

K. Tokoyoda, S. Zehentmeier, A. Hegazy, I. Albrecht, and J. Grün, Professional Memory CD4+ T Lymphocytes Preferentially Reside and Rest in the Bone Marrow, Immunity, vol.30, issue.5, pp.721-751, 2009.
DOI : 10.1016/j.immuni.2009.03.015

L. Zhou, I. Ivanov, R. Spolski, R. Min, and K. Shenderov, IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways, Nature Immunology, vol.178, issue.9, pp.967-74, 2007.
DOI : 10.1128/MCB.24.6.2385-2396.2004

Y. Yang, J. Weiner, Y. Liu, A. Smith, and D. Huss, T-bet is essential for encephalitogenicity of both Th1 and Th17 cells, The Journal of Experimental Medicine, vol.157, issue.7, pp.1549-64, 2009.
DOI : 10.1006/jaut.2001.0520

S. Abromson-leeman, R. Bronson, and M. Dorf, Encephalitogenic T cells that stably express both T-bet and ROR??t consistently produce IFN?? but have a spectrum of IL-17 profiles, Journal of Neuroimmunology, vol.215, issue.1-2, pp.10-24, 2009.
DOI : 10.1016/j.jneuroim.2009.07.007

L. Xu, A. Kitani, I. Fuss, and W. Strober, Cutting Edge: Regulatory T Cells Induce CD4+CD25-Foxp3- T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-??, The Journal of Immunology, vol.178, issue.11, pp.6725-6734, 2007.
DOI : 10.4049/jimmunol.178.11.6725

K. Voo, Y. Wang, F. Santori, C. Boggiano, and Y. Wang, Identification of IL-17-producing FOXP3+ regulatory T cells in humans, Proceedings of the National Academy of Sciences, vol.106, issue.12, pp.4793-4801, 2009.
DOI : 10.1073/pnas.0900408106

J. Van-hamburg, M. De-bruijn, R. De-almeida, C. Van-zwam, M. Van-meurs et al., Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology, European Journal of Immunology, vol.174, issue.9, pp.2573-86, 2008.
DOI : 10.1002/eji.200737840

Y. Zheng, A. Chaudhry, A. Kas, P. Kim, and J. , Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses, Nature, vol.32, issue.7236, pp.351-357, 2009.
DOI : 10.1038/nature07674

T. Mosmann, H. Cherwinski, M. Bond, M. Giedlin, and R. Coffman, Two types of murine helper T cell clone. I. definition according to profiles of lymphokine activities and secreted proteins, J Immunol, vol.136, pp.2348-57, 1986.

A. Hegazy, M. Peine, C. Helmstetter, I. Panse, A. Frhlich et al., Interferons Direct Th2 Cell Reprogramming to Generate a Stable GATA-3+T-bet+ Cell Subset with Combined Th2 and Th1 Cell Functions, Immunity, vol.32, issue.1, pp.116-144, 2010.
DOI : 10.1016/j.immuni.2009.12.004

S. Szabo, A. Dighe, U. Gubler, and K. Murphy, Regulation of the Interleukin (IL)-12R ??2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells, The Journal of Experimental Medicine, vol.147, issue.5, pp.817-841, 1997.
DOI : 10.1084/jem.178.2.567

K. Si, K. Sato, Y. Morishita, S. Vollstedt, and S. Kim, The contribution of transcription factor IRF1 to the Interferon-gamma-Interleukin 12 signaling axis and Th1 versus Th-17 differentiation of CD4+ T cells, Nat Immunol, vol.9, pp.34-41, 2008.

S. Mckarns and R. Schwartz, Distinct Effects of TGF-??1 on CD4+ and CD8+ T Cell Survival, Division, and IL-2 Production: A Role for T Cell Intrinsic Smad3, The Journal of Immunology, vol.174, issue.4, pp.2071-83, 2005.
DOI : 10.4049/jimmunol.174.4.2071

I. Ivanov, L. Zhou, and D. Littman, Transcriptional regulation of Th17 cell differentiation, Seminars in Immunology, vol.19, issue.6, pp.409-426, 2007.
DOI : 10.1016/j.smim.2007.10.011

E. Bettelli, M. Dastrange, and M. Oukka, Foxp3 interacts with nuclear factor of activated T cells and NF-??B to repress cytokine gene expression and effector functions of T helper cells, Proceedings of the National Academy of Sciences, vol.102, issue.14, pp.5138-5181, 2005.
DOI : 10.1073/pnas.0501675102

S. Kamiya, T. Owaki, N. Morishima, F. Fukai, and J. Mizuguchi, An Indispensable Role for STAT1 in IL-27-Induced T-bet Expression but Not Proliferation of Naive CD4+ T Cells, The Journal of Immunology, vol.173, issue.6, pp.3871-3878, 2004.
DOI : 10.4049/jimmunol.173.6.3871

C. Weaver, R. Hatton, P. Mangan, and L. Harrington, IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages, Annual Review of Immunology, vol.25, issue.1, pp.821-52, 2007.
DOI : 10.1146/annurev.immunol.25.022106.141557

A. Richter, M. Löhning, and A. Radbruch, Instruction for Cytokine Expression in T Helper Lymphocytes in Relation to Proliferation and Cell Cycle Progression, Journal of Experimental Medicine, vol.190, issue.10, pp.1439-50, 1999.
DOI : 10.1084/jem.190.10.1439

J. Bird, D. Brown, A. Mullen, N. Moskowitz, and M. Mahowald, Helper T Cell Differentiation Is Controlled by the Cell Cycle, Immunity, vol.9, issue.2, pp.229-266, 1998.
DOI : 10.1016/S1074-7613(00)80605-6

P. Hogan, L. Chen, J. Nardone, and A. Rao, Transcriptional regulation by calcium, calcineurin, and NFAT, Genes & Development, vol.17, issue.18, pp.2205-2237, 2003.
DOI : 10.1101/gad.1102703

S. Im, A. Hueber, S. Monticelli, K. Kang, and A. Rao, Chromatin-level Regulation of the IL10 Gene in T Cells, Journal of Biological Chemistry, vol.279, issue.45, pp.46818-46843, 2004.
DOI : 10.1074/jbc.M401722200

I. Djuretic, D. Levanon, V. Negreanu, Y. Groner, and A. Rao, Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells, Nature Immunology, vol.161, issue.2, pp.145-53, 2007.
DOI : 10.1074/jbc.274.31.21651

Y. Tone and K. Furuuchi, Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer, Nature Immunology, vol.85, issue.2, pp.194-202, 2008.
DOI : 10.1038/ni1549

Z. Yao, Y. Kanno, M. Kerenyi, G. Stephens, and L. Durant, Nonredundant roles for Stat5a/b in directly regulating Foxp3, Blood, vol.109, issue.10, pp.4368-75, 2007.
DOI : 10.1182/blood-2006-11-055756

Y. Liu, P. Zhang, J. Li, A. Kulkarni, and S. Perruche, A critical function for TGF-?? signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells, Nature Immunology, vol.172, issue.6, pp.632-672, 2008.
DOI : 10.1038/nature05368

URL : https://hal.archives-ouvertes.fr/inserm-00484154

A. Villarino, C. Tato, J. Stumhofer, Z. Yao, and Y. Cui, Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals, The Journal of Experimental Medicine, vol.313, issue.1, pp.65-71, 2007.
DOI : 10.1038/nature04790

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118423

D. Tran, H. Ramsey, and E. Shevach, Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-?? dependent but does not confer a regulatory phenotype, Blood, vol.110, issue.8, pp.2983-90, 2007.
DOI : 10.1182/blood-2007-06-094656

N. Manel, D. Unutmaz, and D. Littman, The differentiation of human TH-17 cells requires transforming growth factor-?? and induction of the nuclear receptor ROR??t, Nature Immunology, vol.171, issue.6, pp.641-650, 2008.
DOI : 10.1084/jem.189.11.1735

A. Rudensky, M. Gavin, and Y. Zheng, FOXP3 and NFAT: Partners in Tolerance, Cell, vol.126, issue.2, pp.253-259, 2006.
DOI : 10.1016/j.cell.2006.07.005

E. Hwang, J. Hong, and L. Glimcher, IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508, The Journal of Experimental Medicine, vol.77, issue.9, pp.1289-300, 2005.
DOI : 10.1126/science.275.5308.1930

H. Kwon, J. So, C. Lee, A. Sahoo, and H. Yi, Foxp3 induces IL-4 gene silencing by affecting nuclear translocation of NF??B and chromatin structure, Molecular Immunology, vol.45, issue.11, pp.3205-3217, 2008.
DOI : 10.1016/j.molimm.2008.02.021

B. Elser, M. Lohoff, S. Kock, M. Giaisi, and S. Kirchhoff, IFN-?? Represses IL-4 Expression via IRF-1 and IRF-2, Immunity, vol.17, issue.6, pp.703-715, 2002.
DOI : 10.1016/S1074-7613(02)00471-5

M. Mcgeachy, K. Bak-jensen, Y. Chen, C. Tato, and W. Blumenschein, TGF-?? and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell???mediated pathology, Nature Immunology, vol.22, issue.12, pp.1390-1397, 2007.
DOI : 10.1038/ni1539

A. Laurence, C. Tato, T. Davidson, Y. Kanno, and Z. Chen, Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation, Immunity, vol.26, issue.3, pp.371-81, 2007.
DOI : 10.1016/j.immuni.2007.02.009

Z. Chen, A. Laurence, Y. Kanno, M. Pacher-zavisin, and B. Zhu, Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells, Proceedings of the National Academy of Sciences, vol.103, issue.21, pp.8137-8179, 2006.
DOI : 10.1073/pnas.0600666103

S. Sakaguchi, M. Ono, R. Setoguchi, H. Yagi, and S. Hori, Foxp3+CD25+CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease, Immunological Reviews, vol.25, issue.1, pp.8-27, 2006.
DOI : 10.1111/j.0105-2896.2005.00248.x