The myofibroblast, multiple origins for major roles in normal and pathological tissue repair

Abstract : Myofibroblasts differentiate, invade and repair injured tissues by secreting and organizing the extracellular matrix and by developing contractile forces. When tissues are damaged, tissue homeostasis must be re-established, and repair mechanisms have to rapidly provide harmonious mechanical tissue organization, a process essentially supported by (myo)fibroblasts. Under physiological conditions, the secretory and contractile activities of myofibroblasts are terminated when the repair is complete (scar formation) but the functionality of the tissue is only rarely perfectly restored. At the end of the normal repair process, myofibroblasts disappear by apoptosis but in pathological situations, myofibroblasts likely remain leading to excessive scarring. Myofibroblasts originate from different precursor cells, the major contribution being from local recruitment of connective tissue fibroblasts. However, local mesenchymal stem cells, bone marrow-derived mesenchymal stem cells and cells derived from an epithelial-mesenchymal transition process, may represent alternative sources of myofibroblasts when local fibroblasts are not able to satisfy the requirement for these cells during repair. These diverse cell types probably contribute to the appearance of myofibroblast subpopulations which show specific biological properties and which are important to understand in order to develop new therapeutic strategies for treatment of fibrotic and scarring diseases.
Type de document :
Article dans une revue
Fibrogenesis & Tissue Repair, 2012, 5 (Suppl 1), pp.S5
Liste complète des métadonnées

Littérature citée [38 références]  Voir  Masquer  Télécharger
Contributeur : Ed. Bmc <>
Soumis le : mercredi 6 juin 2012 - 13:06:25
Dernière modification le : mercredi 28 février 2018 - 17:04:01
Document(s) archivé(s) le : vendredi 7 septembre 2012 - 02:30:08



  • HAL Id : inserm-00704838, version 1



Ludovic Micallef, Nicolas Vedrenne, Fabrice Billet, Bernard Coulomb, Ian Darby, et al.. The myofibroblast, multiple origins for major roles in normal and pathological tissue repair. Fibrogenesis & Tissue Repair, 2012, 5 (Suppl 1), pp.S5. 〈inserm-00704838〉



Consultations de la notice


Téléchargements de fichiers