Skip to Main content Skip to Navigation
Journal articles

Quantification of the relative importance of CTL, B cell, NK cell, and target cell limitation in the control of primary SIV-infection.

Abstract : CD8+ cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, B cells and target cell limitation have all been suggested to play a role in the control of SIV and HIV-1 infection. However, previous research typically studied each population in isolation leaving the magnitude, relative importance and in vivo relevance of each effect unclear. Here we quantify the relative importance of CTLs, NK cells, B cells and target cell limitation in controlling acute SIV infection in rhesus macaques. Using three different methods, we find that the availability of target cells and CD8+ T cells are important predictors of viral load dynamics. If CTL are assumed to mediate this anti-viral effect via a lytic mechanism then we estimate that CTL killing is responsible for approximately 40% of productively infected cell death, the remaining cell death being attributable to intrinsic, immune (CD8+ T cell, NK cell, B cell) -independent mechanisms. Furthermore, we find that NK cells have little impact on the death rate of infected CD4+ cells and that their net impact is to increase viral load. We hypothesize that NK cells play a detrimental role in SIV infection, possibly by increasing T cell activation.
Document type :
Journal articles
Complete list of metadatas

Cited literature [92 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00704808
Contributor : Delphine Autard <>
Submitted on : Wednesday, June 6, 2012 - 12:27:54 PM
Last modification on : Tuesday, May 14, 2019 - 6:50:06 PM
Long-term archiving on: : Friday, September 7, 2012 - 2:31:27 AM

File

journal.pcbi.1001103.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Marjet Elemans, Rodolphe Thiébaut, Amitinder Kaur, Becca Asquith. Quantification of the relative importance of CTL, B cell, NK cell, and target cell limitation in the control of primary SIV-infection.. PLoS Computational Biology, Public Library of Science, 2011, 7 (3), pp.e1001103. ⟨10.1371/journal.pcbi.1001103⟩. ⟨inserm-00704808⟩

Share

Metrics

Record views

335

Files downloads

680