. Health, M. Baltimore, and . Ste-foy, 49 The Research Centre of Applied and Preventive Cardiovascular Medicine 56 Marie Krogh Center for Metabolic Research, Faculty of Health Sciences 58 Genetic Epidemiology and Clinical Research Group, Department of Public Health and Clinical Medicine, Section for Medicine 60 Department of Medical Statistics, London School of Hygiene and Tropical Medicine United Kingdom, 61 Finnish Institute of Occupational Health, Oulu, Finland, 62 LIKES Research Center for Sport and Health Sciences 64 Institute of Public Health and Clinical Nutrition The Netherlands, 73 Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom, 74 Icelandic Heart Association, Heart Preventive Clinic and Research Institute South Ostrobothnia Central Hospital Obesity: preventing and managing the global epidemic, 54 Steno Diabetes Centre, Gentofte, Denmark, 55 Faculty of Health Sciences United States of America, 69 Institute of Cell and Molecular Biosciences Intramural Research Program, National Institute on Aging Department of Social Services and Health Care for Human Genetic Research and Diabetes Research Center Department of Life Course and Services, National Institute for Health and Welfare, pp.66-68, 2004.

C. Bouchard, A. Tremblay, J. Despres, A. Nadeau, and T. Lupien, The Response to Long-Term Overfeeding in Identical Twins, New England Journal of Medicine, vol.322, issue.21, pp.1477-1482, 1990.
DOI : 10.1056/NEJM199005243222101

V. Hainer, A. Stunkard, M. Kunesova, J. Parizkova, and V. Stich, Intrapair resemblance in very low calorie diet-induced weight loss in female obese identical twins, International Journal of Obesity, vol.24, issue.8, pp.1051-1057, 2000.
DOI : 10.1038/sj.ijo.0801358

L. Mustelin, K. Silventoinen, K. Pietilä-inen, A. Rissanen, and J. Kaprio, Physical activity reduces the influence of genetic effects on BMI and waist circumference: a study in young adult twins, International Journal of Obesity, vol.24, issue.1, pp.29-36, 2009.
DOI : 10.1038/ijo.2008.258

J. Mccaffery, G. Papandonatos, D. Bond, M. Lyons, and R. Wing, Gene x environment interaction of vigorous exercise and body mass index among male Vietnam-era twins, American Journal of Clinical Nutrition, vol.89, issue.4, pp.1011-1018, 2009.
DOI : 10.3945/ajcn.2008.27170

K. Silventoinen, A. Hasselbalch, T. Lallukka, L. Bogl, and K. Pietilä-inen, Modification effects of physical activity and protein intake on heritability of body size and composition, American Journal of Clinical Nutrition, vol.90, issue.4, pp.1096-1103, 2009.
DOI : 10.3945/ajcn.2009.27689

T. Frayling, N. Timpson, M. Weedon, E. Zeggini, and R. Freathy, A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity, Science, vol.316, issue.5826, pp.889-894, 2007.
DOI : 10.1126/science.1141634

A. Scuteri, S. Sanna, W. Chen, M. Uda, and G. Albai, Genome Wide Association Scan shows Genetic Variants in the FTO gene are Associated with Obesity Related Traits, PLoS Genetics, vol.preprint, issue.2007, 2007.
DOI : 10.1371/journal.pgen.0030115.eor

C. Andreasen, K. Stender-petersen, M. Mogensen, S. Torekov, and L. Wegner, Low Physical Activity Accentuates the Effect of the FTO rs9939609 Polymorphism on Body Fat Accumulation, Diabetes, vol.57, issue.1, pp.95-101, 2008.
DOI : 10.2337/db07-0910

S. Cauchi, F. Stutzmann, C. Cavalcanti-proenca, E. Durand, and A. Pouta, Combined effects of MC4R and FTO common genetic variants on obesity in European general populations, Journal of Molecular Medicine, vol.25, issue.5, pp.537-546, 2009.
DOI : 10.1007/s00109-009-0451-6

J. Jacobsson, U. Riserus, T. Axelsson, L. Lannfelt, and H. Schioth, The common FTOvariant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924, BMC Medical Genetics, vol.458, issue.Suppl 3, p.131, 2009.
DOI : 10.1038/nature07848

H. Lee, I. Kim, J. Kang, Y. Ahn, and B. Han, Effects of common FTO gene variants associated with BMI on dietary intake and physical activity in Koreans, Clinica Chimica Acta, vol.411, issue.21-22, pp.1716-1722, 2010.
DOI : 10.1016/j.cca.2010.07.010

E. Rampersaud, B. Mitchell, T. Pollin, M. Fu, and H. Shen, Physical Activity and the Association of Common FTO Gene Variants With Body Mass Index and Obesity, Archives of Internal Medicine, vol.168, issue.16, pp.1791-1797, 2008.
DOI : 10.1001/archinte.168.16.1791

J. Ruiz, I. Labayen, F. Ortega, V. Legry, and L. Moreno, Attenuation of the Effect of the FTO rs9939609 Polymorphism on Total and Central Body Fat by Physical Activity in Adolescents, Archives of Pediatrics & Adolescent Medicine, vol.164, issue.4, pp.328-333, 2010.
DOI : 10.1001/archpediatrics.2010.29

R. Scott, M. Bailey, C. Moran, R. Wilson, and N. Fuku, FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males, European Journal of Human Genetics, vol.41, issue.12, pp.1339-1343, 2010.
DOI : 10.1038/ejhg.2010.131
URL : https://hal.archives-ouvertes.fr/hal-00567034

E. Sonestedt, C. Roos, B. Gullberg, U. Ericson, and E. Wirfalt, Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity, American Journal of Clinical Nutrition, vol.90, issue.5, pp.1418-1425, 2009.
DOI : 10.3945/ajcn.2009.27958

K. Vimaleswaran, S. Li, J. Zhao, J. Luan, and S. Bingham, Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene, American Journal of Clinical Nutrition, vol.90, issue.2, pp.425-428, 2009.
DOI : 10.3945/ajcn.2009.27652

B. Xi, Y. Shen, M. Zhang, X. Liu, and X. Zhao, The common rs9939609 variant of the fat mass and obesity-associated gene is associated with obesity risk in children and adolescents of Beijing, China, BMC Medical Genetics, vol.50, issue.1, p.107, 2010.
DOI : 10.1007/s00125-007-0839-1

E. Sonestedt, B. Gullberg, U. Ericson, E. Wirfalt, and B. Hedblad, Association between fat intake, physical activity and mortality depending on genetic variation in FTO, International Journal of Obesity, vol.164, issue.8, pp.1041-1049, 2011.
DOI : 10.3945/ajcn.2009.27958

T. Ahmad, I. Lee, G. Pare, D. Chasman, and L. Rose, Lifestyle Interaction With Fat Mass and Obesity-Associated (FTO) Genotype and Risk of Obesity in Apparently Healthy U.S. Women, Diabetes Care, vol.34, issue.3, pp.675-680, 2011.
DOI : 10.2337/dc10-0948

A. Jonsson, F. Renström, V. Lyssenko, E. Brito, and B. Isomaa, Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults, Diabetologia, vol.360, issue.7, pp.1334-1338, 2009.
DOI : 10.1007/s00125-009-1355-2

M. Kaakinen, E. Läärä, A. Pouta, H. Al, and J. Laitinen, Life-Course Analysis of a Fat Mass and Obesity-Associated (FTO) Gene Variant and Body Mass Index in the Northern Finland Birth Cohort 1966 Using Structural Equation Modeling, American Journal of Epidemiology, vol.172, issue.6, pp.653-665, 2010.
DOI : 10.1093/aje/kwq178

T. Lappalainen, A. Tolppanen, M. Kolehmainen, U. Schwab, and J. Lindström, Gene Did Not Modify the Effect of Lifestyle Changes on Body Weight: The Finnish Diabetes Prevention Study, Obesity, vol.316, issue.4, pp.832-836, 2009.
DOI : 10.1038/oby.2008.618

E. Liem, J. Vonk, P. Sauer, G. Van-der-steege, and E. Oosterom, Influence of common variants near INSIG2, in FTO, and near MC4R genes on overweight and the metabolic profile in adolescence: the TRAILS (TRacking Adolescents' Individual Lives Survey) Study, American Journal of Clinical Nutrition, vol.91, issue.2, pp.321-328, 2010.
DOI : 10.3945/ajcn.2009.28186

G. Liu, H. Zhu, V. Lagou, B. Gutin, and I. Stallmann-jorgensen, FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth, BMC Medical Genetics, vol.125, issue.Suppl 1, p.57, 2010.
DOI : 10.1007/s00439-009-0656-3

J. Tan, R. Dorajoo, M. Seielstad, X. Sim, and R. Ong, FTO Variants Are Associated With Obesity in the Chinese and Malay Populations in Singapore, Diabetes, vol.57, issue.10, pp.2851-2857, 2008.
DOI : 10.2337/db08-0214

P. Smith and N. Day, The Design of Case-Control Studies: The Influence of Confounding and Interaction Effects, International Journal of Epidemiology, vol.13, issue.3, pp.356-365, 1984.
DOI : 10.1093/ije/13.3.356

M. Wong, N. Day, J. Luan, K. Chan, and N. Wareham, The detection of gene???environment interaction for continuous traits: should we deal with measurement error by bigger studies or better measurement?, International Journal of Epidemiology, vol.32, issue.1, pp.51-57, 2003.
DOI : 10.1093/ije/dyg002

L. Palla, J. Higgins, N. Wareham, and S. Sharp, Challenges in the Use of Literature-based Meta-Analysis to Examine Gene-Environment Interactions, American Journal of Epidemiology, vol.171, issue.11, 2010.
DOI : 10.1093/aje/kwq051

R. Troiano, D. Berrigan, K. Dodd, L. Masse, and T. Tilert, Physical Activity in the United States Measured by Accelerometer, Medicine & Science in Sports & Exercise, vol.40, issue.1, pp.181-188, 2008.
DOI : 10.1249/mss.0b013e31815a51b3

U. Ekelund, L. Sardinha, S. Anderssen, M. Harro, and P. Franks, Associations between objectively assessed physical activity and indicators of body fatness in 9-to 10-y-old European children: a population-based study from 4 distinct regions in Europe (the European Youth Heart Study), Am J Clin Nutr, vol.80, pp.584-590, 2004.

J. Higgins, S. Thompson, J. Deeks, and D. Altman, Measuring inconsistency in meta-analyses, BMJ, vol.327, issue.7414, pp.557-560, 2003.
DOI : 10.1136/bmj.327.7414.557

C. Bloss, N. Schork, and E. Topol, Effect of Direct-to-Consumer Genomewide Profiling to Assess Disease Risk, New England Journal of Medicine, vol.364, issue.6, pp.524-534, 2011.
DOI : 10.1056/NEJMoa1011893

C. Friedenreich, K. Courneya, H. Neilson, C. Matthews, and G. Willis, Reliability and Validity of the Past Year Total Physical Activity Questionnaire, American Journal of Epidemiology, vol.163, issue.10, pp.959-970, 2006.
DOI : 10.1093/aje/kwj112

M. Hagströmer, R. Troiano, M. Sjöström, and D. Berrigan, Levels and Patterns of Objectively Assessed Physical Activity--A Comparison Between Sweden and the United States, American Journal of Epidemiology, vol.171, issue.10, pp.1055-1064, 2010.
DOI : 10.1093/aje/kwq069

L. Powell, R. Kazlauskaite, C. Shima, and B. Appelhans, Lifestyle in France and the United States: An American Perspective, Journal of the American Dietetic Association, vol.110, issue.6, pp.845-847, 2010.
DOI : 10.1016/j.jada.2010.03.029

P. Franks, K. Jablonski, L. Delahanty, J. Mcateer, and S. Kahn, Assessing gene???treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program, Diabetologia, vol.57, issue.12, pp.2214-2223, 2008.
DOI : 10.1007/s00125-008-1158-x

T. Rankinen, T. Rice, M. Teran-garcia, D. Rao, and C. Bouchard, FTO Genotype Is Associated With Exercise Training???induced Changes in Body Composition, Obesity, vol.294, issue.2, pp.322-326, 2010.
DOI : 10.1194/jlr.M700448-JLR200

J. Mitchell, T. Church, T. Rankinen, C. Earnest, and X. Sui, FTO Genotype and the Weight Loss Benefits of Moderate Intensity Exercise, Obesity, vol.276, issue.3, pp.641-643, 2010.
DOI : 10.1371/journal.pone.0004428