Epilepsy in children, The Lancet, vol.367, issue.9509, pp.499-524, 2006. ,
DOI : 10.1016/S0140-6736(06)68182-8
Obtaining pediatric indications for new anti-epileptic drugs: How and when, Epilepsy Research, vol.68, issue.1, pp.38-42, 2006. ,
DOI : 10.1016/j.eplepsyres.2005.09.016
Clinical development of antiepileptic drugs in adults, Neurotherapeutics, vol.112, issue.suppl 10, pp.62-69, 2007. ,
DOI : 10.1016/j.nurt.2006.11.013
Clinical trials in children, The Lancet, vol.364, issue.9436, pp.803-811, 2004. ,
DOI : 10.1016/S0140-6736(04)16942-0
Pediatric trials: practical issues. Special populations and trial design, Adv Neurol, vol.76, pp.167-171, 1998. ,
Testing Medications in Children, New England Journal of Medicine, vol.347, issue.18, pp.1462-1470, 2002. ,
DOI : 10.1056/NEJMhpr021646
Clinical Pharmacokinetics of New-Generation Antiepileptic Drugs at the Extremes of Age, Clinical Pharmacokinetics, vol.5, issue.10, pp.351-363, 2006. ,
DOI : 10.2165/00003088-200645040-00002
The trials and tribulations of pediatric drug trials, Neurology, vol.65, issue.9, pp.1348-1349, 2005. ,
DOI : 10.1212/01.wnl.0000183475.81594.29
Placebo effects in developmental disabilities: Implications for research and practice, Mental Retardation and Developmental Disabilities Research Reviews, vol.5, issue.2, pp.164-170, 2005. ,
DOI : 10.1002/mrdd.20065
The Placebo Response in Studies of Acute Migraine, The Journal of Pediatrics, vol.152, issue.4, pp.527-560, 2008. ,
DOI : 10.1016/j.jpeds.2007.09.024
The Placebo Responder Rate in Children and Adolescents, Headache: The Journal of Head and Face Pain, vol.34, issue.3, pp.232-239, 2005. ,
DOI : 10.1046/j.1526-4610.1996.3607419.x
Zolmitriptan Oral Tablet in Migraine Treatment: High Placebo Responses in Adolescents, Headache: The Journal of Head and Face Pain, vol.17, issue.7, pp.101-109, 2006. ,
DOI : 10.1111/j.1526-4610.2005.05050.x
Double-Blind, Placebo-Controlled, Lamotrigine in Treatment-Resistant Generalised Epilepsy, Epilepsia, vol.35, issue.12, pp.1329-1333, 1998. ,
DOI : 10.1016/S0967-5868(96)90057-0
Placebo-controlled study of levetiracetam in idiopathic generalized epilepsy, Neurology, vol.69, issue.18, pp.1751-1760, 2007. ,
DOI : 10.1212/01.wnl.0000268699.34614.d3
A randomized, placebo-controlled study of topiramate in primary generalized tonic-clonic seizures, Neurology, vol.52, issue.7, pp.1330-1337, 1999. ,
DOI : 10.1212/WNL.52.7.1330
Double-blind, placebo-controlled study of lamotrigine in primary generalized tonic-clonic seizures, Neurology, vol.65, issue.11, pp.1737-1743, 2005. ,
DOI : 10.1212/01.wnl.0000187118.19221.e4
Gabapentin in generalized seizures, Epilepsy Research, vol.25, issue.3, pp.191-197, 1996. ,
DOI : 10.1016/S0920-1211(96)00020-4
Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome, Neurology, vol.70, issue.21, pp.1950-1958, 2008. ,
DOI : 10.1212/01.wnl.0000303813.95800.0d
Lamotrigine for Generalized Seizures Associated with the Lennox???Gastaut Syndrome, New England Journal of Medicine, vol.337, issue.25, pp.1807-1812, 1997. ,
DOI : 10.1056/NEJM199712183372504
Efficacy and tolerability of the new antiepileptic drugs II: Treatment of refractory epilepsy: Report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society, Neurology, vol.62, issue.8, pp.1261-1273, 2004. ,
DOI : 10.1212/01.WNL.0000123695.22623.32
Guidelines for essential services, personnel, and facilities in specialized epilepsy centers in the United States, Epilepsia, vol.42, pp.804-814, 2001. ,
Pharmacoresistance in Epilepsy, CNS Drugs, vol.10, issue.3, pp.171-179, 1998. ,
DOI : 10.2165/00023210-199810030-00002
Clinical aspects and biological bases of drug-resistant epilepsies, Epilepsy Research, vol.34, issue.2-3, pp.109-122, 1999. ,
DOI : 10.1016/S0920-1211(98)00106-5
International Conference on Harmonisation . ICH topic E11 clinical investigation of medicinal products in the paediatric population Available, 2001. ,
Assessing the quality of reports of randomized clinical trials: Is blinding necessary?, Controlled Clinical Trials, vol.17, issue.1, pp.1-12, 1996. ,
DOI : 10.1016/0197-2456(95)00134-4
Seizure-Free Outcome in Randomized Add-on Trials of the New Antiepileptic Drugs, Epilepsia, vol.32, issue.7, pp.1303-1307, 2007. ,
DOI : 10.1016/0920-1211(93)90011-U
Quantifying heterogeneity in a meta-analysis, Statistics in Medicine, vol.14, issue.11, pp.1539-1558, 2002. ,
DOI : 10.1002/sim.1186
EasyMA Sofware Version Available: http://www. spc.univ-lyon1.fr/easyma, 2000. ,
EasyMA: a program for the meta-analysis of clinical trials, Computer Methods and Programs in Biomedicine, vol.53, issue.3, pp.187-190, 1997. ,
DOI : 10.1016/S0169-2607(97)00016-3
Placebo-controlled trial of topiramate as adjunctive therapy to carbamazepine or phenitoine for partial onset seizures, Epilepsia, vol.37, p.153, 1996. ,
Add-on treatment with Lamotrigine for intractable partial epilepsy: a placebo-controlled, cross-over trial, Epilepsia, vol.34, p.66, 1993. ,
Topiramate add-on for drugresistant partial epilepsy. Cochrane Database Syst Rev CD001417, 2002. ,
Lamotrigine add-on for drugresistant partial epilepsy, 2001. ,
A placebo-controlled trial of lamotrigine add-on therapy for partial seizures in children, Neurology, vol.53, issue.8, pp.1724-1731, 1999. ,
DOI : 10.1212/WNL.53.8.1724
Assessing heterogeneity in meta-analysis: Q statistic or I?? index?, Psychological Methods, vol.11, issue.2, pp.193-206, 2006. ,
DOI : 10.1037/1082-989X.11.2.193
Uncertainty in heterogeneity estimates in meta-analyses, BMJ, vol.335, issue.7626, pp.914-916, 2007. ,
DOI : 10.1136/bmj.39343.408449.80
Epilepsy, Archives of Neurology, vol.64, issue.11, pp.1595-1599, 2007. ,
DOI : 10.1001/archneur.64.11.1595
URL : https://hal.archives-ouvertes.fr/hal-00552732
When do patients forget their seizures? An electroclinical study, Epilepsy & Behavior, vol.9, issue.2, pp.281-285, 2006. ,
DOI : 10.1016/j.yebeh.2006.05.010
Oxcarbazepine add-on for drugresistant partial epilepsy. Cochrane Database Syst Rev CD002028, 2000. ,
Zonisamide add-on for drug-resistant partial epilepsy Available, Cochrane Database Syst Rev CD001416, 2005. ,
Levetiracetam add-on for drug-resistant localization related (partial) epilepsy. Cochrane Database Syst Rev CD001901, 2001. ,
Remacemide for drug-resistant localization related epilepsy. Cochrane Database Syst Rev CD001900, 2002. ,
Pregabalin add-on for drugresistant partial epilepsy. Cochrane Database Syst Rev CD005612, 2008. ,
Gabapentin add-on for drug-resistant partial epilepsy, 2000. ,
DOI : 10.1002/14651858.CD001415
Tiagabine add-on for drug-resistant partial epilepsy. Cochrane Database Syst Rev CD001908, Available, 2002. ,
Levetiracetam, oxcarbazepine, remacemide and zonisamide for drug resistant localization-related epilepsy: a systematic review, Epilepsy Research, vol.46, issue.3, pp.259-270, 2001. ,
DOI : 10.1016/S0920-1211(01)00287-X
The New Antiepileptic Drugs: A Systematic Review of Their Efficacy and Tolerability, Epilepsia, vol.35, issue.1, pp.859-880, 1997. ,
DOI : 10.1016/S0140-6736(95)90581-2
Meta-Analysis and Indirect Comparisons of Levetiracetam With Other Second-Generation Antiepileptic Drugs in Partial Epilepsy, Clinical Neuropharmacology, vol.28, issue.2, pp.72-78, 2005. ,
DOI : 10.1097/01.wnf.0000159956.87511.67
Gabapentin as Add-On Therapy in Children with Refractory Partial Seizures: A 12-Week, Multicentre, Double-Blind, Placebo-Controlled Study, Epilepsia, vol.4, issue.8, pp.1147-1154, 1999. ,
DOI : 10.1016/0140-6736(90)91123-R
A double-blind, randomized trial of topiramate as adjunctive therapy for partial-onset seizures in children, Neurology, vol.52, issue.7, pp.1338-1344, 1999. ,
DOI : 10.1212/WNL.52.7.1338
Gabapentin (Neurontin) as Add-on Therapy in Patients with Partial Seizures: A Double-Blind, Placebo-Controlled Study, Epilepsia, vol.36, issue.4, pp.795-801, 1994. ,
DOI : 10.1016/0922-4106(93)90155-3
Double-Blind, Placebo-Controlled Trial of Topiramate (600 mg Daily) for the Treatment of Refractory Partial Epilepsy, Epilepsia, vol.36, issue.8, pp.763-768, 1996. ,
DOI : 10.1111/j.1528-1157.1996.tb00649.x
Treatment of partial seizures with gabapentin: Double-blind, placebo-controlled, parallel-group study*, Psychiatry and Clinical Neurosciences, vol.62, issue.4, pp.507-515, 2006. ,
DOI : 10.1006/ebeh.2001.0283
Oxcarbazepine adjunctive therapy in infants and young children with partial seizures, Neurology, vol.65, issue.9, pp.1370-1375, 2005. ,
DOI : 10.1212/01.wnl.0000186800.18456.72
Stiripentol in Childhood Partial Epilepsy: Randomized Placebo-Controlled Trial with Enrichment and Withdrawal Design, Journal of Child Neurology, vol.49, issue.6, pp.496-502, 2006. ,
DOI : 10.1177/08830738060210062101
Vigabatrin withdrawal randomized study in children, Epilepsy Research, vol.25, issue.3, pp.209-215, 1996. ,
DOI : 10.1016/S0920-1211(96)00028-9
Antiepileptic Drug Development in Children, Drugs, vol.21, issue.6, pp.17-25, 2008. ,
DOI : 10.2165/00003495-200868010-00002
Adjunctive lamotrigine for partial seizures in patients aged 1 to 24 months Gabapentin in partial epilepsy. UK Gabapentin Study Group, Neurology Lancet, vol.64, issue.335, pp.1114-1117, 1990. ,
Double-Blind Study of Gabapentin in the Treatment of Partial Seizures, Epilepsia, vol.39, issue.4, pp.539-542, 1991. ,
DOI : 10.1111/j.1528-1157.1991.tb04689.x
Double-blind crossover trial of lamotrigine (Lamictal) as add-on therapy in intractable epilepsy, Epilepsy Research, vol.4, issue.3, pp.222-229, 1989. ,
DOI : 10.1016/0920-1211(89)90007-7
Controlled Trial of Lamotrigine (Lamictar) for Refractory Partial Seizures, Epilepsia, vol.27, issue.3, pp.356-363, 1989. ,
DOI : 10.2307/2556170
A randomised double-blind placebo-controlled crossover add-on trial of lamotrigine in patients with treatment-resistant partial seizures, Epilepsy Research, vol.7, issue.2, pp.136-145, 1990. ,
DOI : 10.1016/0920-1211(90)90099-H
Placebo-controlled study of the efficacy and safety of lamotrigine in patients with partial seizures, Neurology, vol.43, issue.11, pp.2284-2291, 1993. ,
DOI : 10.1212/WNL.43.11.2284
Double-blind, placebo controlled, crossover study of lamotrigine in treatment resistant partial seizures., Journal of Neurology, Neurosurgery & Psychiatry, vol.56, issue.5, pp.448-453, 1993. ,
DOI : 10.1136/jnnp.56.5.448
Outcomes of Add-on Treatment with Lamotrigine in Partial Epilepsy, Epilepsia, vol.67, issue.2, pp.312-322, 1993. ,
DOI : 10.1016/0920-1211(92)90049-Y
Lamotrigine Therapy for Partial Seizures: A Multicenter, Placebo-Controlled, Double-Blind, Cross-Over Trial, Epilepsia, vol.33, issue.1, pp.113-121, 1994. ,
DOI : 10.1016/0920-1211(90)90077-9
Controlled trial of lamotrigine (Lamictal??) for treatment-resistant partial seizures, Acta Neurologica Scandinavica, vol.35, issue.Suppl 8, pp.247-252, 1996. ,
DOI : 10.1111/j.1600-0404.1996.tb07060.x
Efficacy and Tolerability of Levetiracetam 3000 mg/d in Patients with Refractory Partial Seizures: A Multicenter, Double-Blind, Responder-Selected Study Evaluating Monotherapy, Epilepsia, vol.30, issue.10, pp.1276-1283, 2000. ,
DOI : 10.1002/ana.410320313
Levetiracetam for partial seizures: Results of a double-blind, randomized clinical trial, Neurology, vol.55, issue.2, pp.236-242, 2000. ,
DOI : 10.1212/WNL.55.2.236
Multicenter Double-Blind, Randomized, Placebo-Controlled Trial of Levetiracetam as Add-On Therapy in Patients with Refractory Partial Seizures, Epilepsia, vol.310, issue.2, pp.1179-1186, 2000. ,
DOI : 10.1177/00912700022009369
Efficacy and Safety of Levetiracetam (up to 2000 mg/day) in Taiwanese Patients with Refractory Partial Seizures: A Multicenter, Randomized, Double-blind, Placebo-controlled Study, Epilepsia, vol.27, issue.1, pp.72-81, 2006. ,
DOI : 10.1097/01.wnf.0000159956.87511.67
Double-blind placebo-controlled trial of adjunctive levetiracetam in pediatric partial seizures, Neurology, vol.66, issue.11, pp.1654-1660, 2006. ,
DOI : 10.1212/01.wnl.0000217916.00225.3a
Oxcarbazepine placebo-controlled, dose-ranging trial in refractory partial epilepsy, Epilepsia, vol.41, pp.1597-1607, 2000. ,
Adjunctive therapy with oxcarbazepine in children with partial seizures, Neurology, vol.54, issue.12, pp.2237-2244, 2000. ,
DOI : 10.1212/WNL.54.12.2237
Double-Blind, Placebo-Controlled Trial of Topiramate as Add-on Therapy in Patients with Refractory Partial Seizures, Epilepsia, vol.43, issue.6, pp.539-543, 1996. ,
DOI : 10.1016/S0140-6736(83)90462-2
Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200-, 400-, and 600-mg daily dosages, Neurology, vol.46, issue.6, pp.1684-1690, 1996. ,
DOI : 10.1212/WNL.46.6.1684
Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 600-, 800-, and 1,000-mg daily dosages, Neurology, vol.46, issue.6, pp.1678-1683, 1996. ,
DOI : 10.1212/WNL.46.6.1678
Double-blind, placebo-controlled study of topiramate in patients with refractory partial epilepsy, Epilepsy Research, vol.25, issue.3, pp.217-224, 1996. ,
DOI : 10.1016/S0920-1211(96)00029-0
A Double-Blind, Placebo-Controlled Study of Topiramate in Adult Patients with Refractory Partial Epilepsy, Epilepsia, vol.37, issue.9, pp.1162-1166, 2000. ,
DOI : 10.1016/S0920-1211(96)00029-0