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SmpB as the handyman of tmRNA during trans-translation.

Brice Felden 1 Reynald Gillet 2, * 
* Corresponding author
2 Equipe Structure et Dynamique des Macromolécules
ICM - Interactions cellulaires et moléculaires
Abstract : In the recent years, a wealth of genetic, biochemical and structural data focusing on various steps of bacterial trans-translation was reported. The early events, from stalled ribosome recognition, pre-accommodation to translocation have been recently investigated in great details. In comparison, the later events including 'elongation-termination' onto tmRNA reading frame and ribosome recycling are much less known. What follows is a summary of those data together with our personal view of the dynamics of trans-translation, with emphasis to the pivotal and leading roles that the SmpB protein has, being the essential conductor during the whole process.
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Submitted on : Wednesday, May 23, 2012 - 9:17:13 AM
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Brice Felden, Reynald Gillet. SmpB as the handyman of tmRNA during trans-translation.. RNA Biol, 2011, 8 (3), pp.440-9. ⟨10.4161/rna.8.3.15387⟩. ⟨inserm-00700119⟩



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