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Journal articles
Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases.
Abstract : ABSTRACT: The ASXL1 gene is one of the most frequently mutated genes in malignant myeloid diseases. The ASXL1 protein belongs to protein complexes involved in the epigenetic regulation of gene expression. ASXL1 mutations are found in myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML). They are generally associated with signs of aggressiveness and poor clinical outcome. Because of this, a systematic determination of ASXL1 mutational status in myeloid malignancies should help in prognosis assessment.
Cited literature [53 references]
https://www.hal.inserm.fr/inserm-00698796
Contributor : Ed. Bmc <>
Submitted on : Thursday, May 17, 2012 - 9:03:09 PM
Last modification on : Wednesday, August 7, 2019 - 2:40:07 PM
Long-term archiving on: : Friday, November 30, 2012 - 11:55:16 AM
Contributor : Ed. Bmc <>
Submitted on : Thursday, May 17, 2012 - 9:03:09 PM
Last modification on : Wednesday, August 7, 2019 - 2:40:07 PM
Long-term archiving on: : Friday, November 30, 2012 - 11:55:16 AM