UGT genomic diversity: beyond gene duplication, Drug Metabolism Reviews, vol.142, issue.1, pp.24-44, 2010. ,
DOI : 10.1159/000106447
Potential Role of UGT Pharmacogenetics in Cancer Treatment and Prevention, Annals of the New York Academy of Sciences, vol.66, issue.2, pp.1155-99, 2009. ,
DOI : 10.1111/j.1749-6632.2009.04114.x
Quantitative analysis of UDPglucuronosyltransferase (UGT) 1A and UGT2B expression levels in human livers, Drug Metab Dispos, vol.37, pp.1759-68, 2009. ,
Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus, Biochem J, issue.2, pp.338-489, 1999. ,
Selectivity of substrate (trifluoperazine) and inhibitor (amitriptyline, androsterone, canrenoic acid, hecogenin, phenylbutazone, quinidine, quinine, and sulfinpyrazone) "probes" for human udp-glucuronosyltransferases, Drug Metab Dispos, vol.34, pp.449-56, 2006. ,
Novel Polymorphic Human UDP-glucuronosyltransferase 2A3: Cloning, Functional Characterization of Enzyme Variants, Comparative Tissue Expression, and Gene Induction, Molecular Pharmacology, vol.74, issue.3, pp.744-54, 2000. ,
DOI : 10.1124/mol.108.045500
Further evidence that morphine-6 beta-glucuronide is a more potent opioid agonist than morphine, J Pharmacol Exp Ther, vol.262, pp.25-31, 1992. ,
Determination of degradation pathways and kinetics of acyl glucuronides by NMR spectroscopy, Chem Res Toxicol, vol.20, pp.876-86, 2007. ,
Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system, Drug Metabolism Reviews, vol.7, issue.2, pp.209-233, 2010. ,
DOI : 10.1124/dmd.106.011387
Isoform???Selective Probe Substrates for In Vitro Studies of Human UDP???Glucuronosyltransferases, Methods Enzymol, vol.400, pp.104-120, 2005. ,
DOI : 10.1016/S0076-6879(05)00007-8
Interactions between Human UGT1A1, UGT1A4, and UGT1A6 Affect Their Enzymatic Activities, Interactions between human UGT1A1, UGT1A4, and UGT1A6 affect their enzymatic activities, pp.1781-1788, 2007. ,
DOI : 10.1124/dmd.107.016402
Human udp-glucuronosyltransferases: isoform 21 ,
Validated assay for studying activity profiles of human liver UGTs after drug exposure: inhibition and induction studies, Analytical and Bioanalytical Chemistry, vol.28, issue.1, pp.2251-63, 2010. ,
DOI : 10.1007/s00216-009-3441-1
Contribution of the Different UDP-Glucuronosyltransferase (UGT) Isoforms to Buprenorphine and Norbuprenorphine Metabolism and Relationship with the Main UGT Polymorphisms in a Bank of Human Liver Microsomes, Drug Metabolism and Disposition, vol.38, issue.1, pp.40-45, 2010. ,
DOI : 10.1124/dmd.109.029546
Glucuronidation of etoposide in human liver microsomes is specifically catalyzed by UDPglucuronosyltransferase 1A1, Drug Metab Dispos, pp.31-589, 2003. ,
Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver, Hepatology, vol.40, issue.5, pp.1158-70, 2006. ,
DOI : 10.1002/hep.21362
IDENTIFICATION OF THE UDP-GLUCURONOSYLTRANSFERASE ISOFORMS INVOLVED IN MYCOPHENOLIC ACID PHASE II METABOLISM, Drug Metabolism and Disposition, vol.33, issue.1, pp.139-185, 2005. ,
DOI : 10.1124/dmd.104.001651
Characterization of bropirimine O-glucuronidation in human liver microsomes, Xenobiotica, vol.33, pp.999-1011, 2003. ,
Isolation and characterization of a novel cDNA encoding a human UDPglucuronosyltransferase active on C19 steroids, J Biol Chem, vol.271, pp.22855-62, 1996. ,
In vitro???in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: Pitfalls and promises, Biochemical Pharmacology, vol.71, issue.11, pp.71-1531, 2006. ,
DOI : 10.1016/j.bcp.2005.12.019
Evidence for oxazepam as an in vivo probe of UGT2B15: oxazepam 23 ,
EVALUATION OF 3'-AZIDO-3'-DEOXYTHYMIDINE, MORPHINE, AND CODEINE AS PROBE SUBSTRATES FOR UDP-GLUCURONOSYLTRANSFERASE 2B7 (UGT2B7) IN HUMAN LIVER MICROSOMES: SPECIFICITY AND INFLUENCE OF THE UGT2B7*2 POLYMORPHISM, Drug Metabolism and Disposition, vol.31, issue.9, pp.31-1125, 2003. ,
DOI : 10.1124/dmd.31.9.1125
Quantitative prediction of in vivo inhibitory interactions involving glucuronidated drugs from in vitro data: the effect of fluconazole on zidovudine glucuronidation, Br J Clin Pharmacol, vol.61, pp.427-466, 2006. ,
A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry, Drug Metab Dispos, vol.29, pp.23-32, 2001. ,
In vitro LC-MS cocktail assays to simultaneously determine human cytochrome P450 activities, Biopharmaceutics & Drug Disposition, vol.30, issue.5, pp.257-62, 2007. ,
DOI : 10.1002/bdd.552
FLUORESCENCE-BASED ASSAYS FOR SCREENING NINE CYTOCHROME P450 (P450) ACTIVITIES IN INTACT CELLS EXPRESSING INDIVIDUAL HUMAN P450 ENZYMES, Drug Metabolism and Disposition, vol.32, issue.7, pp.699-706, 2004. ,
DOI : 10.1124/dmd.32.7.699
Differential Modulation of UDP-Glucuronosyltransferase 1A1 (UGT1A1)-Catalyzed Estradiol-3-glucuronidation by the Addition of UGT1A1 Substrates and Other Compounds to Human Liver Microsomes, Drug Metabolism and Disposition, vol.30, issue.11, pp.1266-73, 2002. ,
DOI : 10.1124/dmd.30.11.1266
Isoflavones modulate the glucuronidation of estradiol in human liver microsomes, Carcinogenesis, vol.26, issue.12, pp.2172-2180, 2005. ,
DOI : 10.1093/carcin/bgi197
The UGT1A1???28 polymorphism correlates with erlotinib???s effect on SN-38 glucuronidation, European Journal of Cancer, vol.46, issue.11, pp.2097-103, 2010. ,
DOI : 10.1016/j.ejca.2010.04.022
Glucuronidation of Dihydrotestosterone and trans-Androsterone by Recombinant UDP-Glucuronosyltransferase (UGT) 1A4: Evidence for Multiple UGT1A4 Aglycone Binding Sites, Drug Metabolism and Disposition, vol.38, issue.3, pp.431-471, 2010. ,
DOI : 10.1124/dmd.109.028712
Kinetic Modeling of the Interactions between 4-Methylumbelliferone, 1-Naphthol, and Zidovudine Glucuronidation by UDP-Glucuronosyltransferase 2B7 (UGT2B7) Provides Evidence for Multiple Substrate Binding and Effector Sites, Molecular Pharmacology, vol.74, issue.4, pp.74-1152, 2008. ,
DOI : 10.1124/mol.108.048645
Pitfalls and Prevention Strategies for Liquid Chromatography-Tandem Mass Spectrometry in the Selected Reaction- Monitoring Mode for Drug Analysis, Clinical Chemistry, vol.54, issue.9, pp.54-1519, 2008. ,
DOI : 10.1373/clinchem.2008.105478
Limited influence of UGT1A1*28 and no effect of UGT2B7*2 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes, British Journal of Clinical Pharmacology, vol.34, issue.4, pp.458-68, 2007. ,
DOI : 10.1016/S0278-6915(01)00087-4
A novel functional polymorphism in the uridine diphosphate???glucuronosyltransferase 2B7 promoter with significant impact on promoter activity, Clinical Pharmacology & Therapeutics, vol.75, issue.3, pp.223-256, 2004. ,
DOI : 10.1016/j.clpt.2003.10.006
Influence of the UGT2B7 promoter region and exon 2 polymorphisms and comedications on Acyl-MPAG production in vitro and in adult renal transplant patients, Pharmacogenetics and Genomics, vol.17, issue.5, pp.17-321, 2007. ,
DOI : 10.1097/FPC.0b013e32801430f8
Glucuronidation of fenamates: Kinetic studies using human kidney cortical microsomes and recombinant UDP-glucuronosyltransferase (UGT) 1A9 and 2B7, Biochemical Pharmacology, vol.73, issue.10, pp.73-1683, 2007. ,
DOI : 10.1016/j.bcp.2007.01.030