the Ellison Foundation (to M DFCI Institute Sponsored Research funds (to M FRS-FNRS grants 7, ) and Interuniversity Attraction Poles Program- Belgian Science Policy ,
Harvard Medical School, 77 Avenue Louis Pasteur, 02215, USA. 2 Department of Genetics Boulevard du Triomphe, 1050 Bruxelles, Belgium. 4 Protein Signaling and Interactions -GIGA Research, p.4000 ,
Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma, Proceedings of the National Academy of Sciences, vol.77, issue.12, pp.7415-7419, 1980. ,
DOI : 10.1073/pnas.77.12.7415
Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera., Proceedings of the National Academy of Sciences, vol.78, issue.10, pp.6476-6480, 1981. ,
DOI : 10.1073/pnas.78.10.6476
ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PATIENTS WITH TROPICAL SPASTIC PARAPARESIS, The Lancet, vol.326, issue.8452, pp.407-410, 1985. ,
DOI : 10.1016/S0140-6736(85)92734-5
A new subtype of human T-cell leukemia virus (HTLV-II) associated with a T-cell variant of hairy cell leukemia, Science, vol.218, issue.4572, pp.571-573, 1982. ,
DOI : 10.1126/science.6981847
Long-term increases in lymphocytes and platelets in human T-lymphotropic virus type II infection, Blood, vol.112, issue.10, pp.3995-4002, 2008. ,
DOI : 10.1182/blood-2008-05-155960
Human T Lymphotropic Virus Type 1 (HTLV-1): Molecular Biology and Oncogenesis, Viruses, vol.2, issue.9, pp.2037-2077, 2010. ,
DOI : 10.3390/v2092037
VirusMINT: a viral protein interaction database, Nucleic Acids Research, vol.37, issue.Database, pp.669-673, 2009. ,
DOI : 10.1093/nar/gkn739
VirHostNet: a knowledge base for the management and the analysis of proteome-wide virus-host interaction networks, Nucleic Acids Research, vol.37, issue.Database, pp.661-668, 2009. ,
DOI : 10.1093/nar/gkn794
URL : https://hal.archives-ouvertes.fr/hal-00428233
Comparative biology of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2, Oncogene, vol.89, issue.39, pp.5996-6004, 2005. ,
DOI : 10.1006/viro.2000.0765
Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences, Viruses, vol.3, issue.12, pp.541-560, 2011. ,
DOI : 10.3390/v3050541
High-Quality Binary Protein Interaction Map of the Yeast Interactome Network, Science, vol.322, issue.5898, pp.104-110, 2008. ,
DOI : 10.1126/science.1158684
An empirical framework for binary interactome mapping, Nature Methods, vol.6, issue.1, pp.83-90, 2009. ,
DOI : 10.1038/nprot.2006.14
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872561
Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network, Nature Methods, vol.6, issue.1, pp.47-54, 2009. ,
DOI : 10.1038/nprot.2006.14
Towards a proteome-scale map of the human protein???protein interaction network, Nature, vol.23, issue.7062, pp.1173-1178, 2005. ,
DOI : 10.1126/science.1090100
Epstein-Barr virus and virus human protein interaction maps, Proceedings of the National Academy of Sciences, vol.104, issue.18, pp.7606-7611, 2007. ,
DOI : 10.1073/pnas.0702332104
Hepatitis C virus infection protein network, Mol Syst Biol, vol.4, p.230, 2008. ,
URL : https://hal.archives-ouvertes.fr/pasteur-00456466
hORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes, Genomics, vol.89, issue.3, pp.307-315, 2007. ,
DOI : 10.1016/j.ygeno.2006.11.012
An experimentally derived confidence score for binary protein-protein interactions, Nature Methods, vol.6, issue.1, pp.91-97, 2009. ,
DOI : 10.1038/nprot.2006.14
Increasing specificity in highthroughput yeast two-hybrid experiments, pp.363-370, 2004. ,
Design and application of a cytokine-receptor-based interaction trap, Nature Cell Biology, vol.3, issue.12, pp.1114-1119, 2001. ,
DOI : 10.1038/ncb1201-1114
The Landscape of Human Proteins Interacting with Viruses and Other Pathogens, PLoS Pathogens, vol.22, issue.2, p.32, 2008. ,
DOI : 10.1371/journal.ppat.0040032.st003
Cloning of ACP33 as a Novel Intracellular Ligand of CD4, Journal of Biological Chemistry, vol.276, issue.12, pp.9123-9132, 2001. ,
DOI : 10.1074/jbc.M009270200
Human MutS and FANCM complexes function as redundant DNA damage sensors in the Fanconi Anemia pathway, DNA Repair, vol.10, issue.12, pp.1203-1212, 2011. ,
DOI : 10.1016/j.dnarep.2011.09.006
Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2, Cell, vol.142, issue.1, pp.65-76, 2010. ,
DOI : 10.1016/j.cell.2010.06.021
Knockdown of ??-Calpain in Fanconi Anemia, FA-A, Cells by siRNA Restores ??II Spectrin Levels and Corrects Chromosomal Instability and Defective DNA Interstrand Cross-Link Repair, Biochemistry, vol.49, issue.26, pp.5570-5581, 2010. ,
DOI : 10.1021/bi100656j
The HTLV-1 Tax interactome, Retrovirology, vol.5, issue.1, p.76, 2008. ,
DOI : 10.1186/1742-4690-5-76
Antagonistic Effects of Cellular Poly(C) Binding Proteins on Vesicular Stomatitis Virus Gene Expression, Journal of Virology, vol.85, issue.18, pp.9459-9471, 2011. ,
DOI : 10.1128/JVI.05179-11
The RNA binding protein RNPS1 alleviates ASF/SF2 depletion-induced genomic instability, RNA, vol.13, issue.12, pp.2108-2115, 2007. ,
DOI : 10.1261/rna.734407
The Diverse Biological Roles of MYST Histone Acetyltransferase Family Proteins, Cell Cycle, vol.6, issue.6, pp.696-704, 2007. ,
DOI : 10.4161/cc.6.6.4013
Immunochemical Characterization and Transacting Properties of Upstream Stimulatory Factor Isoforms, Journal of Biological Chemistry, vol.271, issue.3, pp.1405-1415, 1996. ,
DOI : 10.1074/jbc.271.3.1405
The Human Endosomal Sorting Complex Required for Transport (ESCRT-I) and Its Role in HIV-1 Budding, Journal of Biological Chemistry, vol.279, issue.34, pp.36059-36071, 2004. ,
DOI : 10.1074/jbc.M405226200
Viral Protein R Regulates Docking of the HIV-1 Preintegration Complex to the Nuclear Pore Complex, Journal of Biological Chemistry, vol.273, issue.21, pp.13347-13352, 1998. ,
DOI : 10.1074/jbc.273.21.13347
The Complementary Strand of the Human T-Cell Leukemia Virus Type 1 RNA Genome Encodes a bZIP Transcription Factor That Down-Regulates Viral Transcription, Journal of Virology, vol.76, issue.24, pp.12813-12822, 2002. ,
DOI : 10.1128/JVI.76.24.12813-12822.2002
URL : https://hal.archives-ouvertes.fr/hal-00188771
Human T-cell leukemia virus type 2 produces a spliced antisense transcript encoding a protein that lacks a classic bZIP domain but still inhibits Tax2-mediated transcription, Blood, vol.114, issue.12, pp.2427-2438, 2009. ,
DOI : 10.1182/blood-2008-09-179879
URL : https://hal.archives-ouvertes.fr/hal-00419364
KEGG for linking genomes to life and the environment, Nucleic Acids Research, vol.36, issue.Database, pp.480-484, 2008. ,
DOI : 10.1093/nar/gkm882
Functional analysis of human T-cell leukemia virus type I rex-response element: direct RNA binding of Rex protein correlates with in vivo activity, J Virol, vol.65, pp.4408-4413, 1991. ,
Human T-cell leukemia virus type 2 Rex protein increases stability and promotes nuclear to cytoplasmic transport of gag/pol and env RNAs, J Virol, vol.73, pp.8112-8119, 1999. ,
Phosphorylation regulates human T-cell leukemia virus type 1 Rex function, Retrovirology, vol.6, issue.1, p.105, 2009. ,
DOI : 10.1186/1742-4690-6-105
Kinetic and Molecular Analysis of Nuclear Export Factor CRM1 Association with Its Cargo In Vivo, Molecular and Cellular Biology, vol.25, issue.2, pp.728-739, 2005. ,
DOI : 10.1128/MCB.25.2.728-739.2005
Dynein light chain interacts with NRF-1 and EWG, structurally and functionally related transcription factors from humans and drosophila, J Cell Sci, vol.113, pp.4263-4273, 2000. ,
ERK2 phosphorylation of serine 77 regulates Bmf pro-apoptotic activity, Cell Death and Disease, vol.14, issue.1, p.253, 2012. ,
DOI : 10.1038/cddis.2011.137
Regulation of the human T-cell leukemia virus gene expression depends on the localization of regulatory proteins Tax, Rex and p30II in specific nuclear subdomains, Gene, vol.386, issue.1-2, pp.191-201, 2007. ,
DOI : 10.1016/j.gene.2006.09.008
TRADD???TRAF2 and TRADD???FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways, Cell, vol.84, issue.2, pp.299-308, 1996. ,
DOI : 10.1016/S0092-8674(00)80984-8
URL : http://doi.org/10.1016/s0092-8674(00)80984-8
Rocaglamide breaks TRAIL resistance in HTLV-1-associated adult T-cell leukemia/lymphoma by translational suppression of c-FLIP expression, Cell Death and Differentiation, vol.10, issue.2, pp.362-370, 2011. ,
DOI : 10.1007/s10495-008-0289-3
URL : https://hal.archives-ouvertes.fr/hal-00565454
Physical Interaction of Human T-Cell Leukemia Virus Type 1 Tax with Cyclin-Dependent Kinase 4 Stimulates the Phosphorylation of Retinoblastoma Protein, Molecular and Cellular Biology, vol.22, issue.10, pp.3327-3338, 2002. ,
DOI : 10.1128/MCB.22.10.3327-3338.2002
HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4, EMBO J, vol.15, pp.1607-1614, 1996. ,
Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I, Oncogene, vol.20, issue.17, pp.2055-2067, 2001. ,
DOI : 10.1038/sj.onc.1204304
Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1, Cell, vol.93, issue.1, pp.81-91, 1998. ,
DOI : 10.1016/S0092-8674(00)81148-4
Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein Suppression of Multilineage Hematopoiesis of CD34+ Cells In Vitro, Journal of Virology, vol.77, issue.22, pp.12152-12164, 2003. ,
DOI : 10.1128/JVI.77.22.12152-12164.2003
The Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein Requires the Ubiquitin-Conjugating Enzyme Ubc13 for NF-??B Activation, Journal of Virology, vol.81, issue.24, pp.13735-13742, 2007. ,
DOI : 10.1128/JVI.01790-07
Tax ubiquitylation and SUMOylation control the dynamic shuttling of Tax and NEMO between Ubc9 nuclear bodies and the centrosome, Retrovirology, vol.8, issue.Suppl 1, pp.190-199, 2011. ,
DOI : 10.1186/1742-4690-8-S1-A146
URL : https://hal.archives-ouvertes.fr/hal-00541813
HTLV-1 Tax mutants that do not induce G1 arrest are disabled in activating the anaphase promoting complex, Retrovirology, vol.4, issue.1, p.35, 2007. ,
DOI : 10.1186/1742-4690-4-35
HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule, Proceedings of the National Academy of Sciences, vol.102, issue.1, pp.63-68, 2005. ,
DOI : 10.1073/pnas.0406424101
Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence, The EMBO Journal, vol.24, issue.8, pp.1741-1752, 2006. ,
DOI : 10.1038/sj.emboj.7601054
RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination, Proceedings of the National Academy of Sciences, vol.96, issue.20, pp.11364-11369, 1999. ,
DOI : 10.1073/pnas.96.20.11364
RING Finger Proteins, Cell, vol.102, issue.5, pp.549-552, 2000. ,
DOI : 10.1016/S0092-8674(00)00077-5
The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20, Nature Immunology, vol.81, issue.3, pp.254-262, 2008. ,
DOI : 10.1038/ni1563
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction, Physiological Reviews, vol.82, issue.2, pp.373-428, 2002. ,
DOI : 10.1152/physrev.00027.2001
Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product., Proceedings of the National Academy of Sciences, vol.89, issue.10, pp.4549-4553, 1992. ,
DOI : 10.1073/pnas.89.10.4549
Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 protein, Proceedings of the National Academy of Sciences, vol.100, issue.6, pp.3263-3268, 2003. ,
DOI : 10.1073/pnas.0538058100
Both Rb and E7 are regulated by the ubiquitin proteasome pathway in HPV-containing cervical tumor cells, Oncogene, vol.20, issue.34, pp.4740-4749, 2001. ,
DOI : 10.1038/sj.onc.1204655
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer, Nature, vol.275, issue.7239, pp.732-736, 2009. ,
DOI : 10.1038/nature07884
Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis, pp.1887-1897, 1997. ,
Disturbance of Notch-1 and Wnt signalling proteins in neuroglial balloon cells and abnormal large neurons in focal cortical dysplasia in human cortex, Acta Neuropathologica, vol.98, issue.5, pp.465-472, 1999. ,
DOI : 10.1007/s004010051111
Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency, Cancer Cell, vol.5, issue.2, pp.177-189, 2004. ,
DOI : 10.1016/S1535-6108(04)00022-4
Specific inhibition of CBP/??-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation, Proceedings of the National Academy of Sciences, vol.102, issue.34, pp.12171-12176, 2005. ,
DOI : 10.1073/pnas.0504600102
Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity, Nature Immunology, vol.67, issue.10, pp.1140-1147, 2008. ,
DOI : 10.1016/S1074-7613(03)00111-0
Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia, Proceedings of the National Academy of Sciences, vol.107, issue.38, pp.16619-16624, 2010. ,
DOI : 10.1073/pnas.1010722107
URL : https://hal.archives-ouvertes.fr/hal-00519711
L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid ??-Protein Precursor ??-Secretase Activity, Biochemistry, vol.39, issue.30, pp.8698-8704, 2000. ,
DOI : 10.1021/bi0005456
Cataloguing the HIV Type 1 Human Protein Interaction Network, AIDS Research and Human Retroviruses, vol.24, issue.12, pp.1497-1502, 2008. ,
DOI : 10.1089/aid.2008.0113
Herpesviral Protein Networks and Their Interaction with the Human Proteome, Science, vol.311, issue.5758, pp.239-242, 2006. ,
DOI : 10.1126/science.1116804
Envelope gene sequence of HTLV-1 isolate MT-2 and its comparison with other HTLV-1 isolates, Virology, vol.177, issue.1, pp.391-395, 1990. ,
DOI : 10.1016/0042-6822(90)90498-G
Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA., Proceedings of the National Academy of Sciences, vol.80, issue.12, pp.3618-3622, 1983. ,
DOI : 10.1073/pnas.80.12.3618
Molecular characterization of genome of a novel human T-cell leukaemia virus, Nature, vol.72, issue.5934, pp.502-505, 1983. ,
DOI : 10.1038/305502a0
Nucleotide sequence of the 3' region of an infectious human T-cell leukemia virus type II genome., Proceedings of the National Academy of Sciences, vol.81, issue.21, pp.6657-6661, 1984. ,
DOI : 10.1073/pnas.81.21.6657
HTLV-I antisense transcripts initiating in the 3'LTR are alternatively spliced and polyadenylated, Retrovirology, vol.3, issue.1, p.15, 2006. ,
DOI : 10.1186/1742-4690-3-15
URL : https://hal.archives-ouvertes.fr/hal-00188413
The human T-cell leukemia virus type 1 transactivator protein Tax colocalizes in unique nuclear structures with NF-kappaB proteins, J Virol, vol.71, pp.3484-3497, 1997. ,
Human T-cell leukemia virus type II nucleotide sequences between env and the last exon of tax/rex are not required for viral replication or cellular transformation, J Virol, vol.69, pp.387-394, 1995. ,
High-Throughput Mapping of a Dynamic Signaling Network in Mammalian Cells, Science, vol.307, issue.5715, pp.1621-1625, 2005. ,
DOI : 10.1126/science.1105776
Finding the Maximum Safe Dose Level for Heteroscedastic Data, Journal of Biopharmaceutical Statistics, vol.14, issue.4, pp.843-856, 2004. ,
DOI : 10.1198/016214501753208546
Assessing non-inferiority of a new treatment in a three-arm trial in the presence of heteroscedasticity, Statistics in Medicine, vol.47, issue.4, pp.490-503, 2008. ,
DOI : 10.1002/sim.3052
Genome-scale loss-of-function screening with a lentiviral RNAi library, Nature Methods, vol.102, issue.9, pp.715-719, 2006. ,
DOI : 10.1038/nmeth924
Production and purification of lentiviral vectors, Nature Protocols, vol.6, issue.1, pp.241-245, 2006. ,
DOI : 10.1038/nprot.2006.37
BIND: the Biomolecular Interaction Network Database, Nucleic Acids Research, vol.31, issue.1, pp.248-250, 2003. ,
DOI : 10.1093/nar/gkg056
DIP, the Database of Interacting Proteins: a research tool for studying cellular networks of protein interactions, Nucleic Acids Research, vol.30, issue.1, pp.303-305, 2002. ,
DOI : 10.1093/nar/30.1.303
Human protein reference database--2006 update, Nucleic Acids Research, vol.34, issue.90001, pp.411-414, 2006. ,
DOI : 10.1093/nar/gkj141
IntAct--open source resource for molecular interaction data, Nucleic Acids Research, vol.35, issue.Database, pp.561-565, 2007. ,
DOI : 10.1093/nar/gkl958
MINT: the Molecular INTeraction database, Nucleic Acids Research, vol.35, issue.Database, pp.572-574, 2007. ,
DOI : 10.1093/nar/gkl950
Exploring Biological Networks with Cytoscape Software, Curr Protoc Bioinformatics, vol.513, issue.8, 2008. ,
DOI : 10.1002/0471250953.bi0813s23
Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling, Blood, vol.109, issue.3, pp.1051-1060, 2007. ,
DOI : 10.1182/blood-2006-06-026781
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1785145
Infection of HTLV-III/LAV in HTLV-I-carrying cells MT-2 and MT-4 and application in a plaque assay, Science, vol.229, issue.4713, pp.563-566, 1985. ,
DOI : 10.1126/science.2992081