GPSy: a cross-species gene prioritization system for conserved biological processes--application in male gamete development.

Ramona Britto; Olivier Sallou; Olivier Collin; Grégoire Michaux; Michael Primig; Frédéric Chalmel

GPSy: a cross-species gene prioritization system for conserved biological processes--application in male gamete development.

Ramona Britto ¹ Olivier Sallou ^{2, 3} Olivier Collin ^{2, 3} Grégoire Michaux ⁴ Michael Primig ⁵ Frédéric Chalmel ^{5, *}

* Corresponding author

1 Irset - Institut de recherche, santé, environnement et travail

2 Plateforme bioinformatique GenOuest [Rennes]

IRISA - Institut de Recherche en Informatique et Systèmes Aléatoires, UR1 - Université de Rennes 1, Plateforme Génomique Santé Biogenouest®, Inria Rennes – Bretagne Atlantique

3 SED [Rennes] - Service Expérimentation et Développement

4 IGDR - Institut de Génétique et Développement de Rennes

5 Transcriptional networks in gametogenesis and cancer

Irset - Institut de recherche, santé, environnement et travail

Abstract : We present gene prioritization system (GPSy), a cross-species gene prioritization system that facilitates the arduous but critical task of prioritizing genes for follow-up functional analyses. GPSy's modular design with regard to species, data sets and scoring strategies enables users to formulate queries in a highly flexible manner. Currently, the system encompasses 20 topics related to conserved biological processes including male gamete development discussed in this article. The web server-based tool is freely available at http://gpsy.genouest.org.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Quantitative Methods [q-bio.QM]

Computer Science [cs] / Bioinformatics [q-bio.QM]

Life Sciences [q-bio] / Development Biology

Life Sciences [q-bio] / Reproductive Biology

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https://www.hal.inserm.fr/inserm-00696905
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