Is Elevated Gastric Tissue NOX2 Associated with Lymphoma of Mucosa-Associated Lymphoid Tissue?

Emilie Bessède 1, 2 Christiane Copie-Bergman 3, 4 Philippe Lehours 1, 2 Michael Levy 5 Karen Leroy 4 Maryse Baia 3, 4 Audrey Riou 6 Francis Mégraud 1, 2 Jean-Charles Delchier 5 Nathalie Salles 1, 2, 7, *
* Auteur correspondant
1 Infection à helicobacter, inflammation et cancer
2 Laboratoire de bactériologie
3 IMRB - Institut Mondor de Recherche Biomédicale
4 Département de pathologie [Mondor]
5 Service d'hépato-gastro-entérologie [APHP Henri Mondor]
6 Plateforme de Ressources Biologiques
7 Pôle de Gérontologie Clinique
Abstract : Abstract Helicobacter pylori infection plays a crucial role in the pathogenesis of gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT). However, the host response to this infection is also important in the development of the disease. In particular, NADPH oxidases (NOXs) which generate reactive oxygen species are known to induce cell damage possibly leading to carcinogenesis. We analyze for the first time NOX expression in a series of well characterized gastric MALT lymphoma (GML) patients in comparison with controls. Our observation leads to the hypothesis that NOX2 expression is significantly associated with GML. Antioxid. Redox Signal. 16, 1205-1211.
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Article dans une revue
Antioxidants and Redox Signaling, Mary Ann Liebert, 2012, 16 (11), pp.1205-11. 〈10.1089/ars.2011.4494〉
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Soumis le : lundi 14 mai 2012 - 08:08:30
Dernière modification le : mercredi 13 décembre 2017 - 14:44:03
Document(s) archivé(s) le : mercredi 15 août 2012 - 02:21:57

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Emilie Bessède, Christiane Copie-Bergman, Philippe Lehours, Michael Levy, Karen Leroy, et al.. Is Elevated Gastric Tissue NOX2 Associated with Lymphoma of Mucosa-Associated Lymphoid Tissue?. Antioxidants and Redox Signaling, Mary Ann Liebert, 2012, 16 (11), pp.1205-11. 〈10.1089/ars.2011.4494〉. 〈inserm-00696815〉

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