Prerequisites for ubiquinone analogs to prevent mitochondrial permeability transition-induced cell death. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Journal of Bioenergetics and Biomembranes Année : 2012

Prerequisites for ubiquinone analogs to prevent mitochondrial permeability transition-induced cell death.

Résumé

The permeability transition pore (PTP) is a mitochondrial inner membrane channel involved in cell death. The inhibition of PTP opening has been proved to be an effective strategy to prevent cell death induced by oxidative stress. Several ubiquinone analogs are known to powerfully inhibit PTP opening with an effect depending on the studied cell line. Here, we have studied the effects of ubiquinone 0 (Ub(0)), ubiquinone 5 (Ub(5)) and ubiquinone 10 (Ub(10)) on PTP regulation, H(2)O(2) production and cell viability in U937 cells. We found that Ub(0) induced both PTP opening and H(2)O(2) production. Ub(5) did not regulate PTP opening yet induced H(2)O(2) production. Ub(10) potently inhibited PTP opening yet induced H(2)O(2) production. Both Ub(0) and Ub(5) induced cell death, whereas Ub(10) was not toxic. Moreover, Ub(10) prevented tert-butyl hydroperoxide-induced PTP opening and subsequent cell death. We conclude that PTP-inhibitor ubiquinone analogs are able to prevent PTP opening-induced cell death only if they are not toxic per se, which is the case when they have no or low pro-oxidant activity.

Dates et versions

inserm-00696301 , version 1 (11-05-2012)

Identifiants

Citer

Julie Belliere, Flavien Devun, Cécile Cottet-Rousselle, Cécile Batandier, Xavier Leverve, et al.. Prerequisites for ubiquinone analogs to prevent mitochondrial permeability transition-induced cell death.. Journal of Bioenergetics and Biomembranes, 2012, 44 (1), pp.207-12. ⟨10.1007/s10863-012-9406-7⟩. ⟨inserm-00696301⟩

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