Red blood cell alloimmunization in sickle cell disease: pathophysiology, risk factors, and transfusion management. - Archive ouverte HAL Access content directly
Journal Articles Blood Year : 2012

Red blood cell alloimmunization in sickle cell disease: pathophysiology, risk factors, and transfusion management.

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Abstract

Red blood cell transfusions have reduced morbidity and mortality for patients with sickle cell disease. Transfusions can lead to erythrocyte alloimmunization, however, with serious complications for the patient including life-threatening delayed hemolytic transfusion reactions and difficulty in finding compatible units, which can cause transfusion delays. In this review, we discuss the risk factors associated with alloimmunization with emphasis on possible mechanisms that can trigger delayed hemolytic transfusion reactions in sickle cell disease, and we describe the challenges in transfusion management of these patients, including opportunities and emerging approaches for minimizing this life-threatening complication.
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inserm-00696264 , version 1 (11-11-2012)

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Karina Yazdanbakhsh, Russell E. Ware, France Noizat-Pirenne. Red blood cell alloimmunization in sickle cell disease: pathophysiology, risk factors, and transfusion management.. Blood, 2012, 120 (3), pp.528-37. ⟨10.1182/blood-2011-11-327361⟩. ⟨inserm-00696264⟩

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