Red blood cell alloimmunization in sickle cell disease: pathophysiology, risk factors, and transfusion management.

Karina Yazdanbakhsh 1, * Russell Ware 2 France Noizat-Pirenne 3, 4, *
* Auteur correspondant
1 Laboratory of Complement Biology
2 International Hematology Center of Excellence
3 CIC - Biotherapie - CHU Henri Mondor
4 IMRB - Institut Mondor de Recherche Biomédicale
Abstract : Red blood cell transfusions have reduced morbidity and mortality for patients with sickle cell disease. Transfusions can lead to erythrocyte alloimmunization, however, with serious complications for the patient including life-threatening delayed hemolytic transfusion reactions and difficulty in finding compatible units, which can cause transfusion delays. In this review, we discuss the risk factors associated with alloimmunization with emphasis on possible mechanisms that can trigger delayed hemolytic transfusion reactions in sickle cell disease, and we describe the challenges in transfusion management of these patients, including opportunities and emerging approaches for minimizing this life-threatening complication.
Keywords : sickle cell disease alloimmunization DHTR hyperhemolysis transfusion management T regulatory cells (Tregs) RH variant rare blood groups
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Article dans une revue
Blood, American Society of Hematology, 2012, 120 (3), pp.528-37. 〈10.1182/blood-2011-11-327361〉
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Karina Yazdanbakhsh, Russell Ware, France Noizat-Pirenne. Red blood cell alloimmunization in sickle cell disease: pathophysiology, risk factors, and transfusion management.. Blood, American Society of Hematology, 2012, 120 (3), pp.528-37. 〈10.1182/blood-2011-11-327361〉. 〈inserm-00696264〉

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