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. Switzerland-i, . Dibbert, M. Hazenkamp, P. Brutsche, . Burney et al., Ackermann-Liebrich)U n i t e dK i n g d o m :No r wi ch( DJ ar v is ,BH ar ri son )

E. Regarding and . Ii, Quality of Life programme. The following bodies funded the local studies in ECRHS II in this article Albacete -Fondo de Investigaciones Santarias (grant code: 97/0035-01, 13 99/0034-01 and 99/ 0034-02), Hospital Universitario de Albacete, Consejeria de SanidadAntwerp - FWO (Fund for Scientific Research)-Flanders Belgium (grant code: G.0402.00) Ciber of Epidemiology and Public Health has been established and founded by Instituto de Salud CarlosIIIBergen -Norwegian Research Council, Flemish Health Ministry.Barcelona -Fondo de Investigaciones Sanitarias Swiss Federal Office for Education & Science, Swiss National Accident Insurance Fund

G. Wellcome, A. , N. Research-fund, . Bordeaux-institut-pneumologique-d-'aquitaine, -. Erfurt et al., Comite des Maladies Respiratoires de l'Isere. Hamburg -GSF- National Research Centre for Environment & Health Deutsche Forschungsgemeinschaft (DFG) (grant code MA 711/4-1) Ipswich and Norwich -Asthma UK (formerly National Asthma Campaign) (UK) Huelva - Fondo de Investigaciones Sanitarias (FIS) (grant code: 97/0035-01, 99/0034- 01 and 99/003402) Montpellier -Programme Hospitalier de Recherche Clinique-DRC de Grenoble Ministry of Health, Direction de la Recherche Clinique, CHU de Grenoble, Ministère de l'Emploi et de la Solidarité, Direction Générale de la Santé Aventis (France), Direction Régionale des Affaires Sanitaires et Sociales Languedoc-Roussillon. Oviedo - Fondo de Investigaciones Santarias (FIS) (grant code Paris -Ministère de l'Emploi et de la Solidarite, Direction Générale de la Santé Tartu -Estonian Science Foundation.Umea -Swedish Heart Lung Foundation, Swedish Foundation for Health Care Sciences & Allergy Research, Swedish Asthma & Allergy Foundation, Swedish Cancer & Allergy Foundation. Uppsala -Swedish Heart Lung Foundation, Swedish Foundation for Health Care Sciences & Allergy Research, Swedish Asthma & Allergy Foundation, Swedish Cancer & Allergy Foundation. Further, research has been funded by GABRIEL, a multidisciplinary study to identify the genetic and environmental causes of asthma in the European Community (contract n° 01896 under the Integrated Program LSH-2004-1.2.5-1 Post genomic approaches to understand the molecular bias of asthma aiming at a preventive or therapeutic control), by the Netherlands Organisation for Scientific Research (NWO)/French Ministry of foreign and European affairs Van Gogh program for French-Dutch cooperation and by CIBERESP, which has been established and founded by Instituto de Salud Carlos III (ISC III), Spain. M.A. Valverde is the recipient of an ICREA Academia award and has received support from the Spanish Ministry of Science and Innovation, FEDER Funds and Plan E (grant SAF2009-09848), Generalitat de Catalunya ISCIII-RETIC RD06/02 and Marato TV3 (080430). L.A.M. Smit was supported by a European Academy of Allergology and Clinical Immunology-Global Allergy and Asthma European Network (EAACI-GA 2 LEN) exchange fellowship award. Author details 1, pp.97-132, 1369.

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N. , H. Aec, . Ip, R. Dj, C. et al., ML participated in the acquisition of the data or the analysis and interpretation of such information. LAMS, MK and FK wrote the article MAV had substantial involvement in its revision prior to submission. All authors read and approved the final manuscript. EGEA cooperative group Coordination: F Kauffmann; F Demenais (genetics); I Pin (clinical aspects) Respiratory epidemiology: Inserm U 700, Egea1, issue.Egea1

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