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Defining the critical hurdles in cancer immunotherapy

Bernard Fox 1, 2, * Dolores Schendel 3 Lisa Butterfield 4, 5, 6 Steinar Aamdal 7 James Allison 8, 9 Paolo Antonio Ascierto 10 Michael Atkins 11 Jirina Bartunkova 12 Lothar Bergmann 13 Neil Berinstein 14 Cristina Bonorino 15 Ernest Borden 16, 17 Jonathan Bramson 18 Cedrik Britten 19, 20 Xuetao Cao 21, 22 William Carson 23 Alfred Chang 24 Dainius Characiejus 25 Raja A. Choudhury 26 George Coukos 27 Tanja de Gruijl 28 Robert Dillman 29 Harry Dolstra 30 Glenn Dranoff 31, 32 Lindy Durrant 33 James Finke 34 Jerome Galon 35 Jared Gollob 36 Cécile Gouttefangeas 37 Fabio Grizzi 38 Michele Guida 39 Leif Håkansson 40, 41 Kristen Hege 42 Ronald Herberman 43 Stephen F. Hodi 44, 45 Axel Hoos 46 Christoph Huber 47 Patrick Hwu 48 Kohzoh Imai 49 Elizabeth Jaffee 50 Sylvia Janetzki 51 Carl June 52 Pawel Kalinski 5 Howard Kaufman 53 Koji Kawakami 54 yutaka Kawakami 55 Ulrich Keilholtz 56 Samir Khleif 57 Rolf Kiessling 58 Beatrix Kotlan 59 Guido Kroemer 35 Rejean Lapointe 60 Hyam Levitsky 61 Michael Lotze 4, 5, 6 Cristina Maccalli 62 Michele Maio 63 Jens-Peter Marschner 64 Michael Mastrangelo 65 Giuseppe Masucci 66 Ignacio Melero 67 Cornelius Melief 68 William Murphy 69 Brad Nelson 70 Andrea Nicolini 71 Michael Nishimura 72 Kunle Odunsi 73 Pamela Ohashi 74 Jill O'Donnell-Tormey 75 Lloyd Old 76 Christian Ottensmeier 77 Michael Papamichail 78 Giorgio Parmiani 79 Graham Pawelec 80 Enrico Proietti 81 Shukui Qin 82 Robert Rees 83 Antoni Ribas 84 Ruggero Ridolfi 85 Gerd Ritter 8, 76 Licia Rivoltini 86 Pedro Romero 87 Mohamed Salem 88 Rik Scheper 89 Barbara Seliger 90 Padmanee Sharma 91 Hiroshi Shiku 92, 93 Harpreet Singh-Jasuja 94 Wenru Song 95 Per Thor Straten 96 Hideaki Tahara 97 Zhigang Tian 98, 99 Sjoerd van Der Burg 100 Paul von Hoegen 101 Ena Wang 102, 103 Marij Welters 104 Hauke Winter 105 Tara Withington 106 Jedd Wolchok 8 Weihua Xiao 107 Laurence Zitvogel 108 Heinz Zwierzina 109 Francesco Marincola 76 Thomas Gajewski 110 Jon Wigginton 111 Mary Disis 112 
* Corresponding author
1 Department of Molecular Microbiology and Immunology
2 Earle A. Chiles Research Institute
3 Clinical Cooperation Group "Immune Monitoring"
4 Division of Hematology Oncology
5 Department of Surgery
6 Department of Immunology
7 Department of Clinical Cancer Research
8 Memorial Sloane Kettering Cancer Center [New York]
9 HHMI - Howard Hughes Medical Institute
10 Medical Oncology and Innovative Therapy
11 Beth Israel Deaconess Medical Center
12 Institute of Immunology
13 Goethe-Universität Frankfurt am Main
14 IRX Therapeutics
15 Instituto Nacional para o Controle do Câncer
16 Department of Solid Tumor Oncology
17 Department of Translational Hematology and Oncology Research
18 Department of Pathology
19 University Medical Center Mainz
20 Ribological GmbH
21 Department of Immunology
22 Institute of Immunology
23 Department of Surgery
24 Department of Surgery
25 Institute of Oncology
26 Department of Medicine
27 Ovarian Cancer Research Center
28 Department of Medical Oncology
29 Hoag Institute for Research and Education
30 Department of Laboratory Medicine
31 Department of Medicine
32 Department of Medical Oncology
33 Academic Department of Clinical Oncology
34 Department of Immunology
35 CRC (UMR_S 872) - Centre de Recherche des Cordeliers
36 Alnylam Pharmaceuticals
37 Institute for Cell Biology
38 IRCCS Milan - Istituto Clinico Humanitas [Milan]
39 Oncology Department
40 University of Lund
41 CanImGuide Therapeutics AB
42 UCSF - University of California [San Francisco]
43 Intrexon Corporation
44 Department of Medicine
45 Dana-Farber Cancer Institute [Boston]
46 Bristol-Myers Squibb Company
47 Translational Oncology & Immunology
48 Department of Melanoma Medical Oncology
49 The Institute of Medical Science
50 Department of Oncology
51 ZellNet Consulting
52 Pathology and Laboratory Medicine
53 Rush University Cancer Center
54 School of Medicine and Public Health
55 Division of Cellular Signaling
56 Dept. of Hematology and Medical Oncology
57 Cancer Vaccine Section
58 Department of Oncology - Pathology
59 Department of Molecular Immunology and Toxicology
60 CR CHUM - Centre de Recherche du Centre Hospitalier de l’Université de Montréal
61 School of Medicine
62 Department of Molecular Oncology
63 Medical Oncology and Immunotherapy
64 Merck KGaA
65 Department of Medical Oncology
66 Department of Oncology-Pathology
67 Department of Immunology
68 Department of Immunohematology and Blood Transfusion
69 Davis Medical Center
70 Deeley Research Centre
71 Department of Internal Medicine
72 Oncology Institute
73 Tumor Immunology and Immunotherapy Program
74 Ontario Cancer Institute
75 CIC - Cancer Immunotherapy Consortium
76 Cancer Research
77 Experimental Cancer Medicine Centre
78 Cancer Immunology and Immunotherapy Center
79 Unit of Immuno-Biotherapy of Melanoma and Solid Tumors
80 Center for Medical Research
81 Department of Cell Biology and Neurosciences
82 Chinese PLA Cancer Center
83 The John van Geest Cancer Research Centre
84 Department of Medicine
85 Immunoterapia e Terapia Cellulare Somatica
86 Unit of Immunotherapy of Human Tumors
87 Division of Clinical Onco-Immunology
88 Immunology and Biotechnology Unit
89 Department of Pathology
90 Institute of Medical Immunology
91 Departments of Immunology
92 Department of Cancer Vaccine
93 Department of Immuno-gene Therapy
94 Immatics Biotechnologies GmbH
95 Millennium: The Takeda Oncology Company
96 CCIT - Center for Cancer Immune Therapy
97 Department of Surgery and Bioengineering
98 Institute of Immunology
99 Institute of Immunopharmacology & Immunotherapy
100 Experimental Cancer Immunology and Therapy
101 Euraccine Consulting Group
102 IDIS - Infectious Disease and Immunogenetics Section
103 CHI - Center for Human Immunology
104 Experimental Cancer Immunology and Therapy
105 Department of Surgery
106 Biological Therapy of Cancer
107 Institute of Immunology
108 UMR 1015 - Immunologie des tumeurs et immunothérapie
109 Department Haematology and Oncology
110 Medical Center
111 Discovery Medicine-Oncology
112 Tumor Vaccine Group
Abstract : Scientific discoveries that provide strong evidence of antitumor effects in preclinical models often encounter significant delays before being tested in patients with cancer. While some of these delays have a scientific basis, others do not. We need to do better. Innovative strategies need to move into early stage clinical trials as quickly as it is safe, and if successful, these therapies should efficiently obtain regulatory approval and widespread clinical application. In late 2009 and 2010 the Society for Immunotherapy of Cancer (SITC), convened an "Immunotherapy Summit" with representatives from immunotherapy organizations representing Europe, Japan, China and North America to discuss collaborations to improve development and delivery of cancer immunotherapy. One of the concepts raised by SITC and defined as critical by all parties was the need to identify hurdles that impede effective translation of cancer immunotherapy. With consensus on these hurdles, international working groups could be developed to make recommendations vetted by the participating organizations. These recommendations could then be considered by regulatory bodies, governmental and private funding agencies, pharmaceutical companies and academic institutions to facilitate changes necessary to accelerate clinical translation of novel immune-based cancer therapies. The critical hurdles identified by representatives of the collaborating organizations, now organized as the World Immunotherapy Council, are presented and discussed in this report. Some of the identified hurdles impede all investigators; others hinder investigators only in certain regions or institutions or are more relevant to specific types of immunotherapy or first-in-humans studies. Each of these hurdles can significantly delay clinical translation of promising advances in immunotherapy yet if overcome, have the potential to improve outcomes of patients with cancer.
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Submitted on : Friday, April 27, 2012 - 1:06:59 PM
Last modification on : Saturday, June 25, 2022 - 10:06:47 PM
Long-term archiving on: : Monday, November 26, 2012 - 3:56:38 PM

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Bernard Fox, Dolores Schendel, Lisa Butterfield, Steinar Aamdal, James Allison, et al.. Defining the critical hurdles in cancer immunotherapy. Journal of Translational Medicine, BioMed Central, 2011, 9 (1), pp.214. ⟨10.1186/1479-5876-9-214⟩. ⟨inserm-00691923⟩

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