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Defining the critical hurdles in cancer immunotherapy

Bernard Fox 1, 2, * Dolores Schendel 3 Lisa Butterfield 4, 5, 6 Steinar Aamdal 7 James Allison 8, 9 Paolo Ascierto 10 Michael Atkins 11 Jirina Bartunkova 12 Lothar Bergmann 13 Neil Berinstein 14 Cristina Bonorino 15 Ernest Borden 16, 17 Jonathan Bramson 18 Cedrik Britten 19, 20 Xuetao Cao 21, 22 William Carson 23 Alfred Chang 24 Dainius Characiejus 25 Raja Choudhury 26 George Coukos 27 Tanja de Gruijl 28 Robert Dillman 29 Harry Dolstra 30 Glenn Dranoff 31, 32 Lindy Durrant 33 James Finke 34 Jerome Galon 35 Jared Gollob 36 Cécile Gouttefangeas 37 Fabio Grizzi 38 Michele Guida 39 Leif Håkansson 40, 41 Kristen Hege 42 Ronald Herberman 43 Stephen Hodi 44, 45 Axel Hoos 46 Christoph Huber 47 Patrick Hwu 48 Kohzoh Imai 49 Elizabeth Jaffee 50 Sylvia Janetzki 51 Carl June 52 Pawel Kalinski 5 Howard Kaufman 53 Koji Kawakami 54 Yutaka Kawakami 55 Ulrich Keilholtz 56 Samir Khleif 57 Rolf Kiessling 58 Beatrix Kotlan 59 Guido Kroemer 35 Rejean Lapointe 60 Hyam Levitsky 61 Michael Lotze 4, 5, 6 Cristina Maccalli 62 Michele Maio 63 Jens-Peter Marschner 64 Michael Mastrangelo 65 Giuseppe Masucci 66 Ignacio Melero 67 Cornelius Melief 68 William Murphy 69 Brad Nelson 70 Andrea Nicolini 71 Michael Nishimura 72 Kunle Odunsi 73 Pamela Ohashi 74 Jill O'Donnell-Tormey 75 Lloyd Old 76 Christian Ottensmeier 77 Michael Papamichail 78 Giorgio Parmiani 79 Graham Pawelec 80 Enrico Proietti 81 Shukui Qin 82 Robert Rees 83 Antoni Ribas 84 Ruggero Ridolfi 85 Gerd Ritter 8, 76 Licia Rivoltini 86 Pedro Romero 87 Mohamed Salem 88 Rik Scheper 89 Barbara Seliger 90 Padmanee Sharma 91 Hiroshi Shiku 92, 93 Harpreet Singh-Jasuja 94 Wenru Song 95 Per Straten 96 Hideaki Tahara 97 Zhigang Tian 98, 99 Sjoerd van der Burg 100 Paul von Hoegen 101 Ena Wang 102, 103 Marij Welters 104 Hauke Winter 105 Tara Withington 106 Jedd Wolchok 8 Weihua Xiao 107 Laurence Zitvogel 108 Heinz Zwierzina 109 Francesco Marincola 76 Thomas Gajewski 110 Jon Wigginton 111 Mary Disis 112
* Corresponding author
Abstract : Scientific discoveries that provide strong evidence of antitumor effects in preclinical models often encounter significant delays before being tested in patients with cancer. While some of these delays have a scientific basis, others do not. We need to do better. Innovative strategies need to move into early stage clinical trials as quickly as it is safe, and if successful, these therapies should efficiently obtain regulatory approval and widespread clinical application. In late 2009 and 2010 the Society for Immunotherapy of Cancer (SITC), convened an "Immunotherapy Summit" with representatives from immunotherapy organizations representing Europe, Japan, China and North America to discuss collaborations to improve development and delivery of cancer immunotherapy. One of the concepts raised by SITC and defined as critical by all parties was the need to identify hurdles that impede effective translation of cancer immunotherapy. With consensus on these hurdles, international working groups could be developed to make recommendations vetted by the participating organizations. These recommendations could then be considered by regulatory bodies, governmental and private funding agencies, pharmaceutical companies and academic institutions to facilitate changes necessary to accelerate clinical translation of novel immune-based cancer therapies. The critical hurdles identified by representatives of the collaborating organizations, now organized as the World Immunotherapy Council, are presented and discussed in this report. Some of the identified hurdles impede all investigators; others hinder investigators only in certain regions or institutions or are more relevant to specific types of immunotherapy or first-in-humans studies. Each of these hurdles can significantly delay clinical translation of promising advances in immunotherapy yet if overcome, have the potential to improve outcomes of patients with cancer.
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Bernard Fox, Dolores Schendel, Lisa Butterfield, Steinar Aamdal, James Allison, et al.. Defining the critical hurdles in cancer immunotherapy. Journal of Translational Medicine, BioMed Central, 2011, 9 (1), pp.214. ⟨10.1186/1479-5876-9-214⟩. ⟨inserm-00691923⟩

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