Skip to Main content Skip to Navigation
Journal articles

Interaction of matrix metalloproteinases with pulmonary pollutants.

Abstract : An air pollutant consists of any atmospheric substance that may harm humans, animals, vegetation or material. Various air pollutants have been reported, differing in their physicochemical characteristics. They can be grouped into four categories: gaseous pollutants (e.g. ozone, sulfur dioxide, oxides of nitrogen, carbon monoxide and volatile organic compounds), persistent organic pollutants, heavy metals (e.g. cadmium, lead and mercury) and particulate matter (coarse, fine and ultrafine). These pollutants can reach the respiratory system, eliciting pulmonary and/or systemic effects. These effects include inflammation, tissue remodelling and carcinogenesis: all phenomena where matrix metalloproteases (MMPs) play critical roles, given their broad effects on matrix remodelling and modulation of inflammation and cell signalling. Moreover, since expression and activity of MMPs can be induced by such stimuli, the hypothesis has been raised that MMPs could be involved in the health effects of pollutants. Until now, the implication of MMPs in these effects has been studied only for some pollutants and for a restricted selection of MMPs (mainly MMP-1, -2, -9 and -12), while evidence for a link between MMP induction/activation and health effects remains scarce. A larger number of studies is, therefore, needed in order to better understand the implication of MMPs in health effects associated with air pollution.
Document type :
Journal articles
Complete list of metadatas

Cited literature [79 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00691809
Contributor : Georges Guellaen <>
Submitted on : Friday, April 27, 2012 - 9:12:32 AM
Last modification on : Wednesday, August 19, 2020 - 11:17:03 AM
Long-term archiving on: : Thursday, December 15, 2016 - 2:52:44 AM

Files

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Maylis Dagouassat, Sophie Lanone, Jorge Boczkowski. Interaction of matrix metalloproteinases with pulmonary pollutants.. European Respiratory Journal, European Respiratory Society, 2012, 39 (4), pp.1021-32. ⟨10.1183/09031936.00195811⟩. ⟨inserm-00691809⟩

Share

Metrics

Record views

117