Dose-effect and metabolism of docosahexaenoic acid: Pathophysiological relevance in blood platelets. - Archive ouverte HAL Access content directly
Journal Articles Prostaglandins, Leukotrienes and Essential Fatty Acids Year : 2012

Dose-effect and metabolism of docosahexaenoic acid: Pathophysiological relevance in blood platelets.

(1) , (1) , (1) , (1)
1

Abstract

Docosahexaenoic acid (DHA) is known as a major nutrient from marine origin. Considering its beneficial effect in vascular risk prevention, the effect of DHA on blood components, especially platelets, will be reviewed here. Investigating the dose-effect of DHA in humans shows that daily intake lower than one gram/day brings several benefits, such as inhibition of platelet aggregation, resistance of monocytes against apoptosis, and reinforced antioxidant status in platelets and low-density lipoproteins. However, higher daily intake may be less efficient on those parameters, especially by losing the antioxidant effect. On the other hand, a focus on the inhibition of platelet aggregation by lipoxygenase end-products of DHA is made. The easy conversion of DHA by lipoxygenases and the formation of a double lipoxygenation product named protectin DX, reveal an original way for DHA to contribute in platelet inhibition through both the cyclooxygenase inhibition and the antagonism of thromboxane A(2) action.

Keywords

Fichier principal
Vignette du fichier
PLEFA_2011_ML_et_al._Text_.pdf (85.16 Ko) Télécharger le fichier
Vignette du fichier
PLEFA_2011_ML_et_al._Fig_.pdf (48.44 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)
Loading...

Dates and versions

inserm-00691160 , version 1 (25-04-2012)

Identifiers

Cite

Michel Lagarde, Catherine Calzada, Michel Guichardant, Evelyne Véricel. Dose-effect and metabolism of docosahexaenoic acid: Pathophysiological relevance in blood platelets.. Prostaglandins, Leukotrienes and Essential Fatty Acids, 2012, 88 (1), epub ahead of print. ⟨10.1016/j.plefa.2012.04.001⟩. ⟨inserm-00691160⟩
220 View
594 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More